Effect of supplementation with coffee and cocoa by-products to ameliorate metabolic syndrome alterations induced by high-fat diet in female mice

This article belongs to the Special Issue Editorial Board Members’ Collection Series in “Plant Food Extracts and Phytochemicals”.

Detalles Bibliográficos
Autores: Braojos, Cheyenne, Gila-Diaz, Andrea, Rodríguez-Rodríguez, Pilar, Monedero-Cobeta, Ignacio, Morales, María Dolores, Ruvira, Santiago, Ramiro-Cortijo, David, Benitez, Vanesa, Martín-Cabrejas, María A., Arribas, Silvia M.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/341728
Acceso en línea:http://hdl.handle.net/10261/341728
Access Level:acceso abierto
Palabra clave:Coffee pulp
Cocoa shell
Polyphenols
Caffeine
Glycemia
Adipocytes
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spelling Effect of supplementation with coffee and cocoa by-products to ameliorate metabolic syndrome alterations induced by high-fat diet in female miceBraojos, CheyenneGila-Diaz, AndreaRodríguez-Rodríguez, PilarMonedero-Cobeta, IgnacioMorales, María DoloresRuvira, SantiagoRamiro-Cortijo, DavidBenitez, VanesaMartín-Cabrejas, María A.Arribas, Silvia M.Coffee pulpCocoa shellPolyphenolsCaffeineGlycemiaAdipocytesThis article belongs to the Special Issue Editorial Board Members’ Collection Series in “Plant Food Extracts and Phytochemicals”.Coffee and cocoa manufacturing produces large amounts of waste. Generated by-products contain bioactive compounds with antioxidant and anti-inflammatory properties, suitable for treating metabolic syndrome (MetS). We aimed to compare the efficacy of aqueous extracts and flours from coffee pulp (CfPulp-E, CfPulp-F) and cocoa shell (CcShell-E, CcShell-F) to ameliorate MetS alterations induced by a high-fat diet (HFD). Bioactive component content was assessed by HPLC/MS. C57BL/6 female mice were fed for 6 weeks with HFD followed by 6 weeks with HFD plus supplementation with one of the ingredients (500 mg/kg/day, 5 days/week), and compared to non-supplemented HFD and Control group fed with regular chow. Body weight, adipocyte size and browning (Mitotracker, confocal microscopy), plasma glycemia (basal, glucose tolerance test–area under the curve, GTT-AUC), lipid profile, and leptin were compared between groups. Cocoa shell ingredients had mainly caffeine, theobromine, protocatechuic acid, and flavan-3-ols. Coffee pulp showed a high content in caffeine, protocatechuic, and chlorogenic acids. Compared to Control mice, HFD group showed alterations in all parameters. Compared to HFD, CcShell-F significantly reduced adipocyte size, increased browning and high-density lipoprotein cholesterol (HDL), and normalized basal glycemia, while CcShell-E only increased HDL. Both coffee pulp ingredients normalized adipocyte size, basal glycemia, and GTT-AUC. Additionally, CfPulp-E improved hyperleptinemia, reduced triglycerides, and slowed weight gain, and CfPulp-F increased HDL. In conclusion, coffee pulp ingredients showed a better efficacy against MetS, likely due to the synergic effect of caffeine, protocatechuic, and chlorogenic acids. Since coffee pulp is already approved as a food ingredient, this by-product could be used in humans to treat obesity-related MetS alterations.This research was funded by the Knowledge Transfer Project from Universidad Autónoma de Madrid (UAM, Madrid, Spain) and AORA Health S.L. (Madrid, Spain), grant number PFTC-19; The Excellence Line (2019–2023) for University Teaching Staff within the Multiannual Agreement between the Community of Madrid (Spain)-UAM; and the Spanish Plan for Scientific, Technical and Innovation Research (2021–2023; PEICTI) within the Spanish Recovery, Transformation and Resilience thought the Projects Oriented to the Ecological Transition and to the Digital Transition (Ministry of Science and Innovation; Spain), grant number TED2021-129262A-I00.Peer reviewedMultidisciplinary Digital Publishing InstituteUniversidad Autónoma de MadridComunidad de MadridMinisterio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/341728reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI//TED2021-129262A-I00The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI 10.3390/foods12142708https://doi.org/10.3390/foods12142708Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3417282026-05-22T06:33:51Z
dc.title.none.fl_str_mv Effect of supplementation with coffee and cocoa by-products to ameliorate metabolic syndrome alterations induced by high-fat diet in female mice
title Effect of supplementation with coffee and cocoa by-products to ameliorate metabolic syndrome alterations induced by high-fat diet in female mice
spellingShingle Effect of supplementation with coffee and cocoa by-products to ameliorate metabolic syndrome alterations induced by high-fat diet in female mice
Braojos, Cheyenne
Coffee pulp
Cocoa shell
Polyphenols
Caffeine
Glycemia
Adipocytes
title_short Effect of supplementation with coffee and cocoa by-products to ameliorate metabolic syndrome alterations induced by high-fat diet in female mice
title_full Effect of supplementation with coffee and cocoa by-products to ameliorate metabolic syndrome alterations induced by high-fat diet in female mice
title_fullStr Effect of supplementation with coffee and cocoa by-products to ameliorate metabolic syndrome alterations induced by high-fat diet in female mice
title_full_unstemmed Effect of supplementation with coffee and cocoa by-products to ameliorate metabolic syndrome alterations induced by high-fat diet in female mice
title_sort Effect of supplementation with coffee and cocoa by-products to ameliorate metabolic syndrome alterations induced by high-fat diet in female mice
dc.creator.none.fl_str_mv Braojos, Cheyenne
Gila-Diaz, Andrea
Rodríguez-Rodríguez, Pilar
Monedero-Cobeta, Ignacio
Morales, María Dolores
Ruvira, Santiago
Ramiro-Cortijo, David
Benitez, Vanesa
Martín-Cabrejas, María A.
Arribas, Silvia M.
author Braojos, Cheyenne
author_facet Braojos, Cheyenne
Gila-Diaz, Andrea
Rodríguez-Rodríguez, Pilar
Monedero-Cobeta, Ignacio
Morales, María Dolores
Ruvira, Santiago
Ramiro-Cortijo, David
Benitez, Vanesa
Martín-Cabrejas, María A.
Arribas, Silvia M.
author_role author
author2 Gila-Diaz, Andrea
Rodríguez-Rodríguez, Pilar
Monedero-Cobeta, Ignacio
Morales, María Dolores
Ruvira, Santiago
Ramiro-Cortijo, David
Benitez, Vanesa
Martín-Cabrejas, María A.
Arribas, Silvia M.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Autónoma de Madrid
Comunidad de Madrid
Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Coffee pulp
Cocoa shell
Polyphenols
Caffeine
Glycemia
Adipocytes
topic Coffee pulp
Cocoa shell
Polyphenols
Caffeine
Glycemia
Adipocytes
description This article belongs to the Special Issue Editorial Board Members’ Collection Series in “Plant Food Extracts and Phytochemicals”.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/341728
url http://hdl.handle.net/10261/341728
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI//TED2021-129262A-I00
The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI 10.3390/foods12142708
https://doi.org/10.3390/foods12142708
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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