Adaptation of Tobacco etch potyvirus to a susceptible ecotype of Arabidopsis thaliana capacitates it for systemic infection of other resistant ecotypes

Viral pathogens continue to emerge among humans, domesticated animals and cultivated crops. The existence of genetic variance for resistance in the host population is crucial to the spread of an emerging virus. Models predict that rapid spread decreases with the frequency and diversity of resistance...

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Authors: Lalic, Jasna, Agudelo-Romero, Patricia, Carrasco, Purificación, Elena, Santiago F.
Format: article
Publication Date:2010
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/24979
Online Access:http://hdl.handle.net/10261/24979
Access Level:Open access
Keyword:virus evolution
emerging viruses
local adaptation
Tobacco etch virus
specialism
generalism
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spelling Adaptation of Tobacco etch potyvirus to a susceptible ecotype of Arabidopsis thaliana capacitates it for systemic infection of other resistant ecotypesLalic, JasnaAgudelo-Romero, PatriciaCarrasco, PurificaciónElena, Santiago F.virus evolutionemerging viruseslocal adaptationTobacco etch virusspecialismgeneralismViral pathogens continue to emerge among humans, domesticated animals and cultivated crops. The existence of genetic variance for resistance in the host population is crucial to the spread of an emerging virus. Models predict that rapid spread decreases with the frequency and diversity of resistance alleles in the host population. However, empirical tests of this hypothesis are scarce. Arabiodpsis thaliana – Tobacco etch potyvirus (TEV) provides an experimentally suitable pathosystem for explore the interplay between genetic variation in host’s susceptibility and virus diversity. Systemic infection of A. thaliana with TEV is controlled by three dominant loci, with different ecotypes varying in susceptibility depending on the genetic constitution at these three loci. Here, we show that TEV adaptation to a susceptible ecotype allowed the virus to successfully infect, replicate and induce symptoms in ecotypes that were fully resistant to the ancestral virus. The value of these results is two-fold. First, we showed that the existence of partially susceptible individuals allows for the emerging virus to bypass resistance alleles that the virus has never encountered. Second, the concept of resistance genes may only be valid for a well-defined viral genotype but not for polymorphic viral populations.This work has been supported by grant BFU2009-06993 from the Spanish Ministry of Science and Innovation to S. F. E. J. L. and P. C. are supported by CSIC’s JAE program.Peer reviewedRoyal Society (Great Britain)201020102010info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_65011291577 bytesapplication/pdfhttp://hdl.handle.net/10261/24979reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésPhil. Trans. R. Soc. B365: 1997-2008http://rstb.royalsocietypublishing.org/content/365/1548/1997.full.pdf+htmlinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/249792026-05-22T06:33:51Z
dc.title.none.fl_str_mv Adaptation of Tobacco etch potyvirus to a susceptible ecotype of Arabidopsis thaliana capacitates it for systemic infection of other resistant ecotypes
title Adaptation of Tobacco etch potyvirus to a susceptible ecotype of Arabidopsis thaliana capacitates it for systemic infection of other resistant ecotypes
spellingShingle Adaptation of Tobacco etch potyvirus to a susceptible ecotype of Arabidopsis thaliana capacitates it for systemic infection of other resistant ecotypes
Lalic, Jasna
virus evolution
emerging viruses
local adaptation
Tobacco etch virus
specialism
generalism
title_short Adaptation of Tobacco etch potyvirus to a susceptible ecotype of Arabidopsis thaliana capacitates it for systemic infection of other resistant ecotypes
title_full Adaptation of Tobacco etch potyvirus to a susceptible ecotype of Arabidopsis thaliana capacitates it for systemic infection of other resistant ecotypes
title_fullStr Adaptation of Tobacco etch potyvirus to a susceptible ecotype of Arabidopsis thaliana capacitates it for systemic infection of other resistant ecotypes
title_full_unstemmed Adaptation of Tobacco etch potyvirus to a susceptible ecotype of Arabidopsis thaliana capacitates it for systemic infection of other resistant ecotypes
title_sort Adaptation of Tobacco etch potyvirus to a susceptible ecotype of Arabidopsis thaliana capacitates it for systemic infection of other resistant ecotypes
dc.creator.none.fl_str_mv Lalic, Jasna
Agudelo-Romero, Patricia
Carrasco, Purificación
Elena, Santiago F.
author Lalic, Jasna
author_facet Lalic, Jasna
Agudelo-Romero, Patricia
Carrasco, Purificación
Elena, Santiago F.
author_role author
author2 Agudelo-Romero, Patricia
Carrasco, Purificación
Elena, Santiago F.
author2_role author
author
author
dc.subject.none.fl_str_mv virus evolution
emerging viruses
local adaptation
Tobacco etch virus
specialism
generalism
topic virus evolution
emerging viruses
local adaptation
Tobacco etch virus
specialism
generalism
description Viral pathogens continue to emerge among humans, domesticated animals and cultivated crops. The existence of genetic variance for resistance in the host population is crucial to the spread of an emerging virus. Models predict that rapid spread decreases with the frequency and diversity of resistance alleles in the host population. However, empirical tests of this hypothesis are scarce. Arabiodpsis thaliana – Tobacco etch potyvirus (TEV) provides an experimentally suitable pathosystem for explore the interplay between genetic variation in host’s susceptibility and virus diversity. Systemic infection of A. thaliana with TEV is controlled by three dominant loci, with different ecotypes varying in susceptibility depending on the genetic constitution at these three loci. Here, we show that TEV adaptation to a susceptible ecotype allowed the virus to successfully infect, replicate and induce symptoms in ecotypes that were fully resistant to the ancestral virus. The value of these results is two-fold. First, we showed that the existence of partially susceptible individuals allows for the emerging virus to bypass resistance alleles that the virus has never encountered. Second, the concept of resistance genes may only be valid for a well-defined viral genotype but not for polymorphic viral populations.
publishDate 2010
dc.date.none.fl_str_mv 2010
2010
2010
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/24979
url http://hdl.handle.net/10261/24979
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Phil. Trans. R. Soc. B
365: 1997-2008
http://rstb.royalsocietypublishing.org/content/365/1548/1997.full.pdf+html
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1291577 bytes
application/pdf
dc.publisher.none.fl_str_mv Royal Society (Great Britain)
publisher.none.fl_str_mv Royal Society (Great Britain)
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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