Nanogel Formation from Dilute Solutions of Clickable Elastin-like Recombinamers and its Dependence on Temperature: Two Fractal Gelation Modes

Producción Científica

Detalles Bibliográficos
Autores: González de Torre, Israel, Quintanilla Sierra, Luis, Pinedo Martín, Guillermo, Rodríguez Cabello, José Carlos, Alonso Rodrigo, Matilde
Tipo de recurso: artículo
Fecha de publicación:2014
País:España
Institución:Universidad de Valladolid
Repositorio:UVaDOC. Repositorio Documental de la Universidad de Valladolid
OAI Identifier:oai:uvadoc.uva.es:10324/21773
Acceso en línea:https://doi.org/10.1021/am503651y
http://uvadoc.uva.es/handle/10324/21773
Access Level:acceso abierto
Palabra clave:Nanogeles
id ES_e5e0b1c088d3f804cd4cfb984ece45b2
oai_identifier_str oai:uvadoc.uva.es:10324/21773
network_acronym_str ES
network_name_str España
repository_id_str
spelling Nanogel Formation from Dilute Solutions of Clickable Elastin-like Recombinamers and its Dependence on Temperature: Two Fractal Gelation ModesGonzález de Torre, IsraelQuintanilla Sierra, LuisPinedo Martín, GuillermoRodríguez Cabello, José CarlosAlonso Rodrigo, MatildeNanogelesProducción CientíficaDiluted, complementary, click-reactive elastin-like recombinamer (ELR) solutions have been prepared and mixed at two different temperatures, one below and one above the characteristic transition temperature (Tt) of these chemically modified ELRs. FTIR measurements, size, aspect ratio, zeta potential, and microrheological measurements have been carried out on the nanostructures formed under these dilute conditions as a way to better understand the relationship between the final macroscopic properties of ELR-based hydrogels and the molecular conditions governing the initial stages of the chemical cross- linking process that occurs, especially its dependence on the preparation temperature relative to Tt. As a result, two different fractal modes of gel formation have been found at the two temperatures studied (above and below Tt). Thus, when the reaction mixture is prepared below Tt, essentially one-dimensional linear nanogels with a high aspect ratio are obtained. In contrast, 3D nanogels are formed above Tt, with spherical shapes predominating. These different structures seem to reflect the two molecular organizations of the single components of the mixture under these conditions, namely extended chains below Tt and a spherical arrangement above Tt. In addition to the interest in these nanogels as models for understanding the formation of microscopic structures and differential macroscopic properties under more conventional hydrogel-formation conditions, these nanogels are of interest because of their thermoresponsiveness and biocompatibility, which provide them with potential uses for drug delivery and other biomedical applications in living systems.Junta de Castilla y León (programa de apoyo a proyectos de investigación – Ref. VA244U13)American Chemical Society2014info:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.1021/am503651yhttp://uvadoc.uva.es/handle/10324/21773reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolidinstname:Universidad de ValladolidIngléshttp://pubs.acs.org/journal/aamickinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/oai:uvadoc.uva.es:10324/217732026-06-13T12:44:47Z
dc.title.none.fl_str_mv Nanogel Formation from Dilute Solutions of Clickable Elastin-like Recombinamers and its Dependence on Temperature: Two Fractal Gelation Modes
title Nanogel Formation from Dilute Solutions of Clickable Elastin-like Recombinamers and its Dependence on Temperature: Two Fractal Gelation Modes
spellingShingle Nanogel Formation from Dilute Solutions of Clickable Elastin-like Recombinamers and its Dependence on Temperature: Two Fractal Gelation Modes
González de Torre, Israel
Nanogeles
title_short Nanogel Formation from Dilute Solutions of Clickable Elastin-like Recombinamers and its Dependence on Temperature: Two Fractal Gelation Modes
title_full Nanogel Formation from Dilute Solutions of Clickable Elastin-like Recombinamers and its Dependence on Temperature: Two Fractal Gelation Modes
title_fullStr Nanogel Formation from Dilute Solutions of Clickable Elastin-like Recombinamers and its Dependence on Temperature: Two Fractal Gelation Modes
title_full_unstemmed Nanogel Formation from Dilute Solutions of Clickable Elastin-like Recombinamers and its Dependence on Temperature: Two Fractal Gelation Modes
title_sort Nanogel Formation from Dilute Solutions of Clickable Elastin-like Recombinamers and its Dependence on Temperature: Two Fractal Gelation Modes
dc.creator.none.fl_str_mv González de Torre, Israel
Quintanilla Sierra, Luis
Pinedo Martín, Guillermo
Rodríguez Cabello, José Carlos
Alonso Rodrigo, Matilde
author González de Torre, Israel
author_facet González de Torre, Israel
Quintanilla Sierra, Luis
Pinedo Martín, Guillermo
Rodríguez Cabello, José Carlos
Alonso Rodrigo, Matilde
author_role author
author2 Quintanilla Sierra, Luis
Pinedo Martín, Guillermo
Rodríguez Cabello, José Carlos
Alonso Rodrigo, Matilde
author2_role author
author
author
author
dc.subject.none.fl_str_mv Nanogeles
topic Nanogeles
description Producción Científica
publishDate 2014
dc.date.none.fl_str_mv 2014
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://doi.org/10.1021/am503651y
http://uvadoc.uva.es/handle/10324/21773
url https://doi.org/10.1021/am503651y
http://uvadoc.uva.es/handle/10324/21773
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://pubs.acs.org/journal/aamick
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolid
instname:Universidad de Valladolid
instname_str Universidad de Valladolid
reponame_str UVaDOC. Repositorio Documental de la Universidad de Valladolid
collection UVaDOC. Repositorio Documental de la Universidad de Valladolid
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869422718364942336
score 15,300724

Similares en LA Referencia