Electrospraying as a Technique for the Controlled Synthesis of Biocompatible PLGA@Ag2S and PLGA@Ag2S@SPION Nanocarriers with Drug Release Capability.

Ag2S nanoparticles are near-infrared (NIR) probes providing emission in a specific spectral range (~1200 nm), and superparamagnetic iron oxide nanoparticles (SPION) are colloidal systems able to respond to an external magnetic field. A disadvantage of Ag2S NPs is the attenuated luminescent propertie...

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Autores: Alvear-Jiménez, Alexis, Zabala Gutierrez, Irene, Shen, Yingli, Villaverde, Gonzalo, Lozano-Chamizo, Laura, Guardia, Pablo, Tinoco, Miguel, Garcia-Pinel, Beatriz, Prados, José, Melguizo, Consolación, López-Romero, Manuel, Jaque, Daniel, Filice, Marco, Contreras-Cáceres, Rafael
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/15667
Acceso en línea:http://hdl.handle.net/20.500.12105/15667
Access Level:acceso abierto
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spelling Electrospraying as a Technique for the Controlled Synthesis of Biocompatible PLGA@Ag2S and PLGA@Ag2S@SPION Nanocarriers with Drug Release Capability.Alvear-Jiménez, AlexisZabala Gutierrez, IreneShen, YingliVillaverde, GonzaloLozano-Chamizo, LauraGuardia, PabloTinoco, MiguelGarcia-Pinel, BeatrizPrados, JoséMelguizo, ConsolaciónLópez-Romero, ManuelJaque, DanielFilice, MarcoContreras-Cáceres, RafaelAg2S nanoparticles are near-infrared (NIR) probes providing emission in a specific spectral range (~1200 nm), and superparamagnetic iron oxide nanoparticles (SPION) are colloidal systems able to respond to an external magnetic field. A disadvantage of Ag2S NPs is the attenuated luminescent properties are reduced in aqueous media and human fluids. Concerning SPION, the main drawback is the generation of undesirable clusters that reduce particle stability. Here, we fabricate biocompatible hybrid nanosystems combining Ag2S NPs and SPION by the electrospraying technique for drug delivery purposes. These nanostructures are composed of poly(lactic-co-glycolic acid) (PLGA) as the polymeric matrix in connection with both Ag2S NPs and SPIONs. Initially, we fabricate a hybrid colloidal nanosystem composed of Ag2S NPs in connection with PLGA (PLGA@Ag2S) by three different routes, showing good photoluminescent (PL) properties with relatively high average decay times. Then, we incorporate SPIONs, obtaining a PLGA polymeric matrix containing both Ag2S NPs and SPION (PLGA@Ag2S@SPION). Interestingly, in this hybrid system, the location of Ag2S NPs and SPIONs depends on the synthesis route performed during electrospraying. After a detailed characterization, we demonstrate the encapsulation and release capabilities, obtaining the kinetic release using a model chemotherapeutic drug (maslinic acid). Finally, we perform in vitro cytotoxicity assays using drug-loaded hybrid systems against several tumor cell lines.Multidisciplinary Digital Publishing Institute (MDPI)Comunidad de Madrid (España)Complutense University of Madrid (España)Regional Government of Andalusia (España)Instituto de Salud Carlos IIIMinisterio de Ciencia, Innovación y Universidades (España)Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)20232023-03-1720222022-01-1720222022-01-17journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.12105/15667reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/156672026-06-12T12:43:37Z
dc.title.none.fl_str_mv Electrospraying as a Technique for the Controlled Synthesis of Biocompatible PLGA@Ag2S and PLGA@Ag2S@SPION Nanocarriers with Drug Release Capability.
title Electrospraying as a Technique for the Controlled Synthesis of Biocompatible PLGA@Ag2S and PLGA@Ag2S@SPION Nanocarriers with Drug Release Capability.
spellingShingle Electrospraying as a Technique for the Controlled Synthesis of Biocompatible PLGA@Ag2S and PLGA@Ag2S@SPION Nanocarriers with Drug Release Capability.
Alvear-Jiménez, Alexis
title_short Electrospraying as a Technique for the Controlled Synthesis of Biocompatible PLGA@Ag2S and PLGA@Ag2S@SPION Nanocarriers with Drug Release Capability.
title_full Electrospraying as a Technique for the Controlled Synthesis of Biocompatible PLGA@Ag2S and PLGA@Ag2S@SPION Nanocarriers with Drug Release Capability.
title_fullStr Electrospraying as a Technique for the Controlled Synthesis of Biocompatible PLGA@Ag2S and PLGA@Ag2S@SPION Nanocarriers with Drug Release Capability.
title_full_unstemmed Electrospraying as a Technique for the Controlled Synthesis of Biocompatible PLGA@Ag2S and PLGA@Ag2S@SPION Nanocarriers with Drug Release Capability.
title_sort Electrospraying as a Technique for the Controlled Synthesis of Biocompatible PLGA@Ag2S and PLGA@Ag2S@SPION Nanocarriers with Drug Release Capability.
dc.creator.none.fl_str_mv Alvear-Jiménez, Alexis
Zabala Gutierrez, Irene
Shen, Yingli
Villaverde, Gonzalo
Lozano-Chamizo, Laura
Guardia, Pablo
Tinoco, Miguel
Garcia-Pinel, Beatriz
Prados, José
Melguizo, Consolación
López-Romero, Manuel
Jaque, Daniel
Filice, Marco
Contreras-Cáceres, Rafael
author Alvear-Jiménez, Alexis
author_facet Alvear-Jiménez, Alexis
Zabala Gutierrez, Irene
Shen, Yingli
Villaverde, Gonzalo
Lozano-Chamizo, Laura
Guardia, Pablo
Tinoco, Miguel
Garcia-Pinel, Beatriz
Prados, José
Melguizo, Consolación
López-Romero, Manuel
Jaque, Daniel
Filice, Marco
Contreras-Cáceres, Rafael
author_role author
author2 Zabala Gutierrez, Irene
Shen, Yingli
Villaverde, Gonzalo
Lozano-Chamizo, Laura
Guardia, Pablo
Tinoco, Miguel
Garcia-Pinel, Beatriz
Prados, José
Melguizo, Consolación
López-Romero, Manuel
Jaque, Daniel
Filice, Marco
Contreras-Cáceres, Rafael
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Comunidad de Madrid (España)
Complutense University of Madrid (España)
Regional Government of Andalusia (España)
Instituto de Salud Carlos III
Ministerio de Ciencia, Innovación y Universidades (España)
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
description Ag2S nanoparticles are near-infrared (NIR) probes providing emission in a specific spectral range (~1200 nm), and superparamagnetic iron oxide nanoparticles (SPION) are colloidal systems able to respond to an external magnetic field. A disadvantage of Ag2S NPs is the attenuated luminescent properties are reduced in aqueous media and human fluids. Concerning SPION, the main drawback is the generation of undesirable clusters that reduce particle stability. Here, we fabricate biocompatible hybrid nanosystems combining Ag2S NPs and SPION by the electrospraying technique for drug delivery purposes. These nanostructures are composed of poly(lactic-co-glycolic acid) (PLGA) as the polymeric matrix in connection with both Ag2S NPs and SPIONs. Initially, we fabricate a hybrid colloidal nanosystem composed of Ag2S NPs in connection with PLGA (PLGA@Ag2S) by three different routes, showing good photoluminescent (PL) properties with relatively high average decay times. Then, we incorporate SPIONs, obtaining a PLGA polymeric matrix containing both Ag2S NPs and SPION (PLGA@Ag2S@SPION). Interestingly, in this hybrid system, the location of Ag2S NPs and SPIONs depends on the synthesis route performed during electrospraying. After a detailed characterization, we demonstrate the encapsulation and release capabilities, obtaining the kinetic release using a model chemotherapeutic drug (maslinic acid). Finally, we perform in vitro cytotoxicity assays using drug-loaded hybrid systems against several tumor cell lines.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-01-17
2022
2022-01-17
2023
2023-03-17
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/15667
url http://hdl.handle.net/20.500.12105/15667
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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