Lewy body dementias: A coin with two sides?

Lewy body dementias (LBDs) consist of dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD), which are clinically similar syndromes that share neuropathological findings with widespread cortical Lewy body deposition, often with a variable degree of concomitant Alzheimer patholo...

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Autores: Milán-Tomás, A. (Ángela)|||/items/5a9efc9f-8848-4835-9f26-dc2c469156d3, Fernández, M. (Marta)|||/items/07978790-ff04-4678-bd69-31ece0c447b3, Rodriguez-Oroz, M.C. (María Cruz)|||/items/ba71432e-1a59-4a6d-87af-ba74627ba030
Formato: artículo
Fecha de publicación:2021
País:España
Recursos:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/115045
Acesso em linha:https://hdl.handle.net/10171/115045
Access Level:acceso abierto
Palavra-chave:Lewy body dementias
Parkinson disease dementia
Biomarkers
Dementia with Lewy bodies
Diagnosis
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spelling Lewy body dementias: A coin with two sides?Milán-Tomás, A. (Ángela)|||/items/5a9efc9f-8848-4835-9f26-dc2c469156d3Fernández, M. (Marta)|||/items/07978790-ff04-4678-bd69-31ece0c447b3Rodriguez-Oroz, M.C. (María Cruz)|||/items/ba71432e-1a59-4a6d-87af-ba74627ba030Lewy body dementiasParkinson disease dementiaBiomarkersDementia with Lewy bodiesDiagnosisLewy body dementias (LBDs) consist of dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD), which are clinically similar syndromes that share neuropathological findings with widespread cortical Lewy body deposition, often with a variable degree of concomitant Alzheimer pathology. The objective of this article is to provide an overview of the neuropathological and clinical features, current diagnostic criteria, biomarkers, and management of LBD. Literature research was performed using the PubMed database, and the most pertinent articles were read and are discussed in this paper. The diagnostic criteria for DLB have recently been updated, with the addition of indicative and supportive biomarker information. The time interval of dementia onset relative to parkinsonism remains the major distinction between DLB and PDD, underpinning controversy about whether they are the same illness in a different spectrum of the disease or two separate neurodegenerative disorders. The treatment for LBD is only symptomatic, but the expected progression and prognosis differ between the two entities. Diagnosis in prodromal stages should be of the utmost importance, because implementing early treatment might change the course of the illness if disease-modifying therapies are developed in the future. Thus, the identification of novel biomarkers constitutes an area of active research, with a special focus on α-synuclein markers.MDPIDadun. Depósito Académico Digital Universidad de Navarra20212021-01-0120212021-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/115045reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/1150452026-06-21T12:47:57Z
dc.title.none.fl_str_mv Lewy body dementias: A coin with two sides?
title Lewy body dementias: A coin with two sides?
spellingShingle Lewy body dementias: A coin with two sides?
Milán-Tomás, A. (Ángela)|||/items/5a9efc9f-8848-4835-9f26-dc2c469156d3
Lewy body dementias
Parkinson disease dementia
Biomarkers
Dementia with Lewy bodies
Diagnosis
title_short Lewy body dementias: A coin with two sides?
title_full Lewy body dementias: A coin with two sides?
title_fullStr Lewy body dementias: A coin with two sides?
title_full_unstemmed Lewy body dementias: A coin with two sides?
title_sort Lewy body dementias: A coin with two sides?
dc.creator.none.fl_str_mv Milán-Tomás, A. (Ángela)|||/items/5a9efc9f-8848-4835-9f26-dc2c469156d3
Fernández, M. (Marta)|||/items/07978790-ff04-4678-bd69-31ece0c447b3
Rodriguez-Oroz, M.C. (María Cruz)|||/items/ba71432e-1a59-4a6d-87af-ba74627ba030
author Milán-Tomás, A. (Ángela)|||/items/5a9efc9f-8848-4835-9f26-dc2c469156d3
author_facet Milán-Tomás, A. (Ángela)|||/items/5a9efc9f-8848-4835-9f26-dc2c469156d3
Fernández, M. (Marta)|||/items/07978790-ff04-4678-bd69-31ece0c447b3
Rodriguez-Oroz, M.C. (María Cruz)|||/items/ba71432e-1a59-4a6d-87af-ba74627ba030
author_role author
author2 Fernández, M. (Marta)|||/items/07978790-ff04-4678-bd69-31ece0c447b3
Rodriguez-Oroz, M.C. (María Cruz)|||/items/ba71432e-1a59-4a6d-87af-ba74627ba030
author2_role author
author
dc.contributor.none.fl_str_mv Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv Lewy body dementias
Parkinson disease dementia
Biomarkers
Dementia with Lewy bodies
Diagnosis
topic Lewy body dementias
Parkinson disease dementia
Biomarkers
Dementia with Lewy bodies
Diagnosis
description Lewy body dementias (LBDs) consist of dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD), which are clinically similar syndromes that share neuropathological findings with widespread cortical Lewy body deposition, often with a variable degree of concomitant Alzheimer pathology. The objective of this article is to provide an overview of the neuropathological and clinical features, current diagnostic criteria, biomarkers, and management of LBD. Literature research was performed using the PubMed database, and the most pertinent articles were read and are discussed in this paper. The diagnostic criteria for DLB have recently been updated, with the addition of indicative and supportive biomarker information. The time interval of dementia onset relative to parkinsonism remains the major distinction between DLB and PDD, underpinning controversy about whether they are the same illness in a different spectrum of the disease or two separate neurodegenerative disorders. The treatment for LBD is only symptomatic, but the expected progression and prognosis differ between the two entities. Diagnosis in prodromal stages should be of the utmost importance, because implementing early treatment might change the course of the illness if disease-modifying therapies are developed in the future. Thus, the identification of novel biomarkers constitutes an area of active research, with a special focus on α-synuclein markers.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-01-01
2021
2021-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10171/115045
url https://hdl.handle.net/10171/115045
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra
instname:Universidad de Navarra
instname_str Universidad de Navarra
reponame_str Dadun. Depósito Académico Digital de la Universidad de Navarra
collection Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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