Epigenetic Regulation of miR-212 Expression in Lung Cancer

Many studies have shown that microRNA expression in cancer may be regulated by epigenetic events. Recently, we found that in lung cancer miR-212 was strongly down-regulated. However, mechanisms involved in the regulation of miR-212 expression are unknown. Therefore, we addressed this point by invest...

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Detalhes bibliográficos
Autores: Incoronato, Mariarosaria, Urso, Loredana, Portela, Anna, Laukkanen, Mikko O., Soini, Ylermi, Quintavalle, Ylermi, Keller, Simona, Esteller, Manel, Condorelli, Gerolama
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2011
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositório:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/126610
Acesso em linha:https://hdl.handle.net/2445/126610
Access Level:Acceso aberto
Palavra-chave:ADN
Càncer de pulmó
DNA
Lung cancer
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spelling Epigenetic Regulation of miR-212 Expression in Lung CancerIncoronato, MariarosariaUrso, LoredanaPortela, AnnaLaukkanen, Mikko O.Soini, YlermiQuintavalle, YlermiKeller, SimonaEsteller, ManelCondorelli, GerolamaADNCàncer de pulmóDNALung cancerMany studies have shown that microRNA expression in cancer may be regulated by epigenetic events. Recently, we found that in lung cancer miR-212 was strongly down-regulated. However, mechanisms involved in the regulation of miR-212 expression are unknown. Therefore, we addressed this point by investigating the molecular mechanisms of miR-212 silencing in lung cancer. We identified histone modifications rather than DNA hypermethylation as epigenetic events that regulate miR-212 levels in NSCLC. Moreover, we found that miR-212 silencing in vivo is closely associated with the severity of the disease.Public Library of Science (PLoS)2018201820112018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion10 p.application/pdfhttps://hdl.handle.net/2445/126610Articles publicats en revistes (Ciències Fisiològiques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1371/journal.pone.0027722PLoS One, 2011, vol. 6, num. 11, p. e27722https://doi.org/10.1371/journal.pone.0027722cc by (c) Incoronato et al., 2011http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1266102026-05-29T05:05:01Z
dc.title.none.fl_str_mv Epigenetic Regulation of miR-212 Expression in Lung Cancer
title Epigenetic Regulation of miR-212 Expression in Lung Cancer
spellingShingle Epigenetic Regulation of miR-212 Expression in Lung Cancer
Incoronato, Mariarosaria
ADN
Càncer de pulmó
DNA
Lung cancer
title_short Epigenetic Regulation of miR-212 Expression in Lung Cancer
title_full Epigenetic Regulation of miR-212 Expression in Lung Cancer
title_fullStr Epigenetic Regulation of miR-212 Expression in Lung Cancer
title_full_unstemmed Epigenetic Regulation of miR-212 Expression in Lung Cancer
title_sort Epigenetic Regulation of miR-212 Expression in Lung Cancer
dc.creator.none.fl_str_mv Incoronato, Mariarosaria
Urso, Loredana
Portela, Anna
Laukkanen, Mikko O.
Soini, Ylermi
Quintavalle, Ylermi
Keller, Simona
Esteller, Manel
Condorelli, Gerolama
author Incoronato, Mariarosaria
author_facet Incoronato, Mariarosaria
Urso, Loredana
Portela, Anna
Laukkanen, Mikko O.
Soini, Ylermi
Quintavalle, Ylermi
Keller, Simona
Esteller, Manel
Condorelli, Gerolama
author_role author
author2 Urso, Loredana
Portela, Anna
Laukkanen, Mikko O.
Soini, Ylermi
Quintavalle, Ylermi
Keller, Simona
Esteller, Manel
Condorelli, Gerolama
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ADN
Càncer de pulmó
DNA
Lung cancer
topic ADN
Càncer de pulmó
DNA
Lung cancer
description Many studies have shown that microRNA expression in cancer may be regulated by epigenetic events. Recently, we found that in lung cancer miR-212 was strongly down-regulated. However, mechanisms involved in the regulation of miR-212 expression are unknown. Therefore, we addressed this point by investigating the molecular mechanisms of miR-212 silencing in lung cancer. We identified histone modifications rather than DNA hypermethylation as epigenetic events that regulate miR-212 levels in NSCLC. Moreover, we found that miR-212 silencing in vivo is closely associated with the severity of the disease.
publishDate 2011
dc.date.none.fl_str_mv 2011
2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/126610
url https://hdl.handle.net/2445/126610
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0027722
PLoS One, 2011, vol. 6, num. 11, p. e27722
https://doi.org/10.1371/journal.pone.0027722
dc.rights.none.fl_str_mv cc by (c) Incoronato et al., 2011
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Incoronato et al., 2011
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 10 p.
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Fisiològiques)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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