Single nucleotide polymorphisms in DNA repair genes as risk factors associated to prostate cancer progression

Background: Besides serum levels of PSA, there is a lack of prostate cancer specific biomarkers. It is need to develop new biological markers associated with the tumor behavior which would be valuable to better individualize treatment. The aim of this study was to elucidate the relationship between...

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Detalles Bibliográficos
Autores: Henríquez Hernández, Luis Alberto, Valenciano, Almudena, Foro Arnalot, Palmira, Álvarez Cubero, María Jesús, Cozar, José Manuel, Suárez Novo, José Francisco, Castells Esteve, Manel, Fernández Gonzalo, Pablo, De-Paula Carranza, Belén, Ferrer Forés, Maria Montserrat, Guedea, Ferrán, Sancho-Pardo, Gemma, Craven-Bartle, Jordi, Ortiz-Gordillo, María José, Cabrera Roldán, Patricia, Herrera Ramos, Estefanía, Rodríguez Gallego, Carlos, Rodríguez Melcón, Juan Ignacio, Lara, Pedro C.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/53711
Acceso en línea:http://hdl.handle.net/10230/53711
http://dx.doi.org/10.1186/s12881-014-0143-0
Access Level:acceso abierto
Palabra clave:Single nucleotide polymorphism
ERCC1
ATM
Prostate cancer
OpenArray
DNA repair
Spanish cohort
Descripción
Sumario:Background: Besides serum levels of PSA, there is a lack of prostate cancer specific biomarkers. It is need to develop new biological markers associated with the tumor behavior which would be valuable to better individualize treatment. The aim of this study was to elucidate the relationship between single nucleotide polymorphisms (SNPs) in genes involved in DNA repair and prostate cancer progression. Methods: A total of 494 prostate cancer patients from a Spanish multicenter study were genotyped for 10 SNPs in XRCC1, ERCC2, ERCC1, LIG4, ATM and TP53 genes. The SNP genotyping was made in a Biotrove OpenArray® NT Cycler. Clinical tumor stage, diagnostic PSA serum levels, and Gleason score at diagnosis were obtained for all participants. Genotypic and allelic frequencies were determined using the web-based environment SNPator. Results: SNPs rs11615 (ERCC1) and rs17503908 (ATM) appeared as risk factors for prostate cancer aggressiveness. Patients wild homozygous for these SNPs (AA and TT, respectively) were at higher risk for developing cT2b - cT4 (OR = 2.21 (confidence interval (CI) 95% 1.47 - 3.31), p < 0.001) and Gleason scores ≥ 7 (OR = 2.22 (CI 95% 1.38 - 3.57), p < 0.001), respectively. Moreover, those patients wild homozygous for both SNPs had the greatest risk of presenting D'Amico high-risk tumors (OR = 2.57 (CI 95% 1.28 - 5.16)). Conclusions: Genetic variants at DNA repair genes are associated with prostate cancer progression, and would be taken into account when assessing the malignancy of prostate cancer.

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