FCGR polymorphisms in the treatment of rheumatoid arthritis with Fc-containing TNF inhibitors

[EN] Objectives: Reproducible association of a functional polymorphism in FCGR2A with response to a TNF inhibitor (TNFi) in patients with rheumatoid arthritis (RA) led us to explore other FcγR functional polymorphisms. Methods: Functional polymorphisms FCGR3A F158V, FCGR2B I223T and promoter VNTR in...

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Detalles Bibliográficos
Autores: Montes Martínez, Ariadna, Pérez Pampín, Eva, Joven, B, Carreira, P, Fernández-Nebro, A, Del Carmen Ordoñez, M, Navarro Sarabia, F, Moreira, V, Vasilopoulos, Y, Sarafidou, T, Caliz, R, Ferrer, MA, Cañete, JD, de la Serna, AR, Magallares, B, Narváez, J, Gómez-Reino Carnota, Juan Jesús, Gonzalez, A
Tipo de recurso: artículo
Fecha de publicación:2015
País:España
Institución:Servizo Galego de Saúde (SERGAS)
Repositorio:RUNA. Repositorio da Consellería de Sanidade e Sergas
OAI Identifier:oai:runa.sergas.gal:20.500.11940/17662
Acceso en línea:http://hdl.handle.net/20.500.11940/17662
Access Level:acceso abierto
Palabra clave:Biomarkers, Pharmacological
Arthritis, Rheumatoid
Receptors, Fc
Rheumatology
Infliximab
Etanercept
Spain
Arthritis
Genotype
Adalimumab
biomarcadores farmacológicos
receptores Fc
genotipo
reumatología
artritis reumatoide
artritis
FCGRT
TNF inhibitors
CHUS
IDIS
Descripción
Sumario:[EN] Objectives: Reproducible association of a functional polymorphism in FCGR2A with response to a TNF inhibitor (TNFi) in patients with rheumatoid arthritis (RA) led us to explore other FcγR functional polymorphisms. Methods: Functional polymorphisms FCGR3A F158V, FCGR2B I223T and promoter VNTR in FCGRT were analyzed in up to 429 patients with RA. Response to TNFi was recorded during standard care at 3, 6 and 12 months of follow-up. Fixed effects meta-analysis of studies addressing FCGR3A F158V polymorphism, which is the most studied of these polymorphisms, was conducted with inverse variance weighting. Results: None of the functional polymorphisms were associated with change in DAS28. Meta-analysis of the seven studies (899 patients) with available data addressing association of FCGR3A F158V with response to TNFi in RA showed no association (OR: 1.11, 95% CI: 0.8-1.5; p = 0.5). Conclusion: None of the three functional polymorphisms in FcγR genes showed association with response to TNFi in patients with RA. These negative results were obtained in spite of the larger size of this study relative to previous studies addressing the same polymorphisms. In addition, meta-analysis of FCGR3A F158V was also negative against the results provided by previous studies.

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