Curcumin as a hepatoprotective agent against chemotherapy-induced liver injury

Despite significant advances in cancer therapeutics, chemotherapy remains the cornerstone of treatment for many tumors. Importantly, however, chemotherapy-induced toxicity, including hepatotoxicity, can lead to the interruption or discontinuation of potentially effective therapy. In recent years, sp...

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Autores: Ruiz de Porras, Vicenç, Figols, Mariona, Font, Albert, Pardina Arrese, Eva
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/219029
Acceso en línea:https://hdl.handle.net/2445/219029
Access Level:acceso abierto
Palabra clave:Cúrcuma
Curcumina
Càncer
Cromatografia
Curcuma
Curcumin
Cancer
Chromatography
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spelling Curcumin as a hepatoprotective agent against chemotherapy-induced liver injuryRuiz de Porras, VicençFigols, MarionaFont, AlbertPardina Arrese, EvaCúrcumaCurcuminaCàncerCromatografiaCurcumaCurcuminCancerChromatographyDespite significant advances in cancer therapeutics, chemotherapy remains the cornerstone of treatment for many tumors. Importantly, however, chemotherapy-induced toxicity, including hepatotoxicity, can lead to the interruption or discontinuation of potentially effective therapy. In recent years, special attention has been paid to the search for complementary therapies to mitigate chemotherapy-induced toxicity. Although there is currently a lack of specific interventions to mitigate or prevent hepatotoxicity in chemotherapy-treated patients, the polyphenol compound curcumin has emerged as a potential strategy to overcome this adverse effect. Here we review, f irstly, the molecular and physiological mechanisms and major risk factors of chemotherapy-induced hepatotoxicity. We then present an overview of how curcumin has the potential to mitigate hepatotoxicity by targeting specific molecular mechanisms. Hepatotoxicity is a well-described side effect of cytotoxic drugs that can limit their clinical application. Inflammation and oxidative stress are the most common mechanisms involved in hepatotoxicity. Several studies have shown that curcumin could prevent and/or palliate chemotherapy-induced liver injury, mainly due to its anti-inflammatory, antioxidant, antifibrotic and hypolipidemic properties. Further clinical investigation using bioavailable curcumin formulations is warranted to demonstrate its efficacy as an hepatoprotective agent in cancer patients.Elsevier2025202520232025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion1 p.application/pdfhttps://hdl.handle.net/2445/219029Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1016/j.lfs.2023.122119Life Sciences, 2023https://doi.org/10.1016/j.lfs.2023.122119cc-by-nc-nd (c) Vicenç Ruiz de Porras, et al., 2023http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2190292026-05-29T05:05:01Z
dc.title.none.fl_str_mv Curcumin as a hepatoprotective agent against chemotherapy-induced liver injury
title Curcumin as a hepatoprotective agent against chemotherapy-induced liver injury
spellingShingle Curcumin as a hepatoprotective agent against chemotherapy-induced liver injury
Ruiz de Porras, Vicenç
Cúrcuma
Curcumina
Càncer
Cromatografia
Curcuma
Curcumin
Cancer
Chromatography
title_short Curcumin as a hepatoprotective agent against chemotherapy-induced liver injury
title_full Curcumin as a hepatoprotective agent against chemotherapy-induced liver injury
title_fullStr Curcumin as a hepatoprotective agent against chemotherapy-induced liver injury
title_full_unstemmed Curcumin as a hepatoprotective agent against chemotherapy-induced liver injury
title_sort Curcumin as a hepatoprotective agent against chemotherapy-induced liver injury
dc.creator.none.fl_str_mv Ruiz de Porras, Vicenç
Figols, Mariona
Font, Albert
Pardina Arrese, Eva
author Ruiz de Porras, Vicenç
author_facet Ruiz de Porras, Vicenç
Figols, Mariona
Font, Albert
Pardina Arrese, Eva
author_role author
author2 Figols, Mariona
Font, Albert
Pardina Arrese, Eva
author2_role author
author
author
dc.subject.none.fl_str_mv Cúrcuma
Curcumina
Càncer
Cromatografia
Curcuma
Curcumin
Cancer
Chromatography
topic Cúrcuma
Curcumina
Càncer
Cromatografia
Curcuma
Curcumin
Cancer
Chromatography
description Despite significant advances in cancer therapeutics, chemotherapy remains the cornerstone of treatment for many tumors. Importantly, however, chemotherapy-induced toxicity, including hepatotoxicity, can lead to the interruption or discontinuation of potentially effective therapy. In recent years, special attention has been paid to the search for complementary therapies to mitigate chemotherapy-induced toxicity. Although there is currently a lack of specific interventions to mitigate or prevent hepatotoxicity in chemotherapy-treated patients, the polyphenol compound curcumin has emerged as a potential strategy to overcome this adverse effect. Here we review, f irstly, the molecular and physiological mechanisms and major risk factors of chemotherapy-induced hepatotoxicity. We then present an overview of how curcumin has the potential to mitigate hepatotoxicity by targeting specific molecular mechanisms. Hepatotoxicity is a well-described side effect of cytotoxic drugs that can limit their clinical application. Inflammation and oxidative stress are the most common mechanisms involved in hepatotoxicity. Several studies have shown that curcumin could prevent and/or palliate chemotherapy-induced liver injury, mainly due to its anti-inflammatory, antioxidant, antifibrotic and hypolipidemic properties. Further clinical investigation using bioavailable curcumin formulations is warranted to demonstrate its efficacy as an hepatoprotective agent in cancer patients.
publishDate 2023
dc.date.none.fl_str_mv 2023
2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/219029
url https://hdl.handle.net/2445/219029
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/j.lfs.2023.122119
Life Sciences, 2023
https://doi.org/10.1016/j.lfs.2023.122119
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Vicenç Ruiz de Porras, et al., 2023
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Vicenç Ruiz de Porras, et al., 2023
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1 p.
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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