Involvement of Cellular Prion Protein in α-Synuclein Transport in Neurons

The cellular prion protein, encoded by the gene Prnp, has been reported to be a receptor of β-amyloid. Their interaction is mandatory for neurotoxic effects of βamyloid oligomers. In this study, we aimed to explore whether the cellular prion protein participates in the spreading of α-synuclein. Resu...

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Detalles Bibliográficos
Autores: Urrea, Laura, Segura-Feliu, Miriam, Masuda-Suzukake, Masami, Hervera Abad, Arnau|||0000-0001-8362-369X, Pedraz, Lucas, García Aznar, José Manuel, Vila Bover, Miquel|||0000-0002-1352-989X, Samitier, Josep|||0000-0002-1140-3679, Torrents, Eduard|||0000-0002-3010-1609, Ferrer, Isidro|||0000-0001-9888-8754, Gavín, Rosalina|||0000-0003-1982-2162, Hagesawa, Masato, Rio, Jose Antonio del|||0000-0002-5214-4909
Tipo de recurso: artículo
Fecha de publicación:2017
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:188578
Acceso en línea:https://ddd.uab.cat/record/188578
https://dx.doi.org/urn:doi:10.1007/s12035-017-0451-4
Access Level:acceso abierto
Palabra clave:Synuclein
Amyloid spreading
Prnp
Microfluidic devices
Descripción
Sumario:The cellular prion protein, encoded by the gene Prnp, has been reported to be a receptor of β-amyloid. Their interaction is mandatory for neurotoxic effects of βamyloid oligomers. In this study, we aimed to explore whether the cellular prion protein participates in the spreading of α-synuclein. Results demonstrate that Prnp expression is not mandatory for α-synuclein spreading. However, although the pathological spreading of αsynuclein can take place in the absence of Prnp, αsynuclein expanded faster in PrPC-overexpressing mice.

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