Gemini imidazolium gels enhance the photodynamic performance of porphyrins

Photodynamic therapy (PDT) successful clinical use has led to an emerging interest in the development of improved delivery systems for photosensitizers. Amongst different formulations, gels have the advantage of being easier to apply, providing greater adhesion to the affected region and allowing li...

Descripción completa

Detalles Bibliográficos
Autores: Anguluri, Kavya, Bagherpour, Saman, Abelha, Thais F., Pérez García, M. Lluïsa (Maria Lluïsa)
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2023
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/208090
Acceso en línea:https://hdl.handle.net/2445/208090
Access Level:acceso abierto
Palabra clave:Compostos heterocíclics
Química farmacèutica
Heterocyclic compounds
Pharmaceutical chemistry
id ES_e53aebc2edc02b8d3ef258fa50948154
oai_identifier_str oai:diposit.ub.edu:2445/208090
network_acronym_str ES
network_name_str España
repository_id_str
spelling Gemini imidazolium gels enhance the photodynamic performance of porphyrinsAnguluri, KavyaBagherpour, SamanAbelha, Thais F.Pérez García, M. Lluïsa (Maria Lluïsa)Compostos heterocíclicsQuímica farmacèuticaHeterocyclic compoundsPharmaceutical chemistryPhotodynamic therapy (PDT) successful clinical use has led to an emerging interest in the development of improved delivery systems for photosensitizers. Amongst different formulations, gels have the advantage of being easier to apply, providing greater adhesion to the affected region and allowing light penetration. Importantly, we have previously reported that by incorporating porphyrin into a bisimidazolium gelator matrix there is an increased reactive oxygen species (ROS) generation compared to the photosensitizer in solution [1]. Motivated by this, we report further assessment on the photosensitizing capabilities of porphyrins in a gel structure. In this work, we evaluated effect of varying the chemical structures of porphyrins on their photosensitizing capabilities whilst embedded within a supramolecular hydrogel based on gemini imidazolium amphiphiles. The investigated porphyrins presented enhanced singlet oxygen (1O2) within the hydrogel matrix compared to solution and showed negligent release in relevant biological media. Rheological measurements revealed that porphyrin hydrogels presented desirable viscoelastic properties as a functional delivery system for PDT.Elsevier2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/208090Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a:Photodiagnosis and Photodynamic Therapy, 2023, vol. 41, p. 103447cc-by-nc-nd (c) British Medical Laser Association ; Polish Society for Photodynamic Medicine, 2023http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2080902026-05-27T06:46:51Z
dc.title.none.fl_str_mv Gemini imidazolium gels enhance the photodynamic performance of porphyrins
title Gemini imidazolium gels enhance the photodynamic performance of porphyrins
spellingShingle Gemini imidazolium gels enhance the photodynamic performance of porphyrins
Anguluri, Kavya
Compostos heterocíclics
Química farmacèutica
Heterocyclic compounds
Pharmaceutical chemistry
title_short Gemini imidazolium gels enhance the photodynamic performance of porphyrins
title_full Gemini imidazolium gels enhance the photodynamic performance of porphyrins
title_fullStr Gemini imidazolium gels enhance the photodynamic performance of porphyrins
title_full_unstemmed Gemini imidazolium gels enhance the photodynamic performance of porphyrins
title_sort Gemini imidazolium gels enhance the photodynamic performance of porphyrins
dc.creator.none.fl_str_mv Anguluri, Kavya
Bagherpour, Saman
Abelha, Thais F.
Pérez García, M. Lluïsa (Maria Lluïsa)
author Anguluri, Kavya
author_facet Anguluri, Kavya
Bagherpour, Saman
Abelha, Thais F.
Pérez García, M. Lluïsa (Maria Lluïsa)
author_role author
author2 Bagherpour, Saman
Abelha, Thais F.
Pérez García, M. Lluïsa (Maria Lluïsa)
author2_role author
author
author
dc.subject.none.fl_str_mv Compostos heterocíclics
Química farmacèutica
Heterocyclic compounds
Pharmaceutical chemistry
topic Compostos heterocíclics
Química farmacèutica
Heterocyclic compounds
Pharmaceutical chemistry
description Photodynamic therapy (PDT) successful clinical use has led to an emerging interest in the development of improved delivery systems for photosensitizers. Amongst different formulations, gels have the advantage of being easier to apply, providing greater adhesion to the affected region and allowing light penetration. Importantly, we have previously reported that by incorporating porphyrin into a bisimidazolium gelator matrix there is an increased reactive oxygen species (ROS) generation compared to the photosensitizer in solution [1]. Motivated by this, we report further assessment on the photosensitizing capabilities of porphyrins in a gel structure. In this work, we evaluated effect of varying the chemical structures of porphyrins on their photosensitizing capabilities whilst embedded within a supramolecular hydrogel based on gemini imidazolium amphiphiles. The investigated porphyrins presented enhanced singlet oxygen (1O2) within the hydrogel matrix compared to solution and showed negligent release in relevant biological media. Rheological measurements revealed that porphyrin hydrogels presented desirable viscoelastic properties as a functional delivery system for PDT.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/208090
url https://hdl.handle.net/2445/208090
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a:
Photodiagnosis and Photodynamic Therapy, 2023, vol. 41, p. 103447
dc.rights.none.fl_str_mv cc-by-nc-nd (c) British Medical Laser Association ; Polish Society for Photodynamic Medicine, 2023
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) British Medical Laser Association ; Polish Society for Photodynamic Medicine, 2023
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869422660664950784
score 15,300719

Similares en LA Referencia