Feasibility of a Multimodal Prehabilitation Programme in Patients Undergoing Cytoreductive Surgery for Advanced Ovarian Cancer: A Pilot Study

Introduction: Treatment for advanced ovarian cancer (AOC) comprises cytoreductive surgery combined with chemotherapy. Multimodal prehabilitation programmes before surgery have demonstrated efficacy in postoperative outcomes in non-gynaecological surgeries. However, the viability and effects of these...

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Autores: Díaz Feijoo, Berta, Agustí, Núria, Sebio García, Raquel, López-Hernández, Antonio, Siso, Marina, Glickman, Ariel, Carreras Dieguez, Núria, Fusté, Pere, Marina, Tiermes, Martínez-Egea, Judit, Aguilera, Laura, Perdomo, Juan Manuel, Pelaez, Amaia, López-Baamonde, Manuel, Navarro Ripoll, Ricard, Gimeno, Elena, Campero, Betina, Torné Bladé, Aureli, Martínez Palli, Graciela, Arguis Giménez, María José
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/195560
Acceso en línea:https://hdl.handle.net/2445/195560
Access Level:acceso abierto
Palabra clave:Càncer d'ovari
Cirurgia ginecològica
Quimioteràpia del càncer
Malalts de càncer
Ovarian cancer
Gynecologic surgery
Cancer chemotherapy
Cancer patients
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spelling Feasibility of a Multimodal Prehabilitation Programme in Patients Undergoing Cytoreductive Surgery for Advanced Ovarian Cancer: A Pilot StudyDíaz Feijoo, BertaAgustí, NúriaSebio García, RaquelLópez-Hernández, AntonioSiso, MarinaGlickman, ArielCarreras Dieguez, NúriaFusté, PereMarina, TiermesMartínez-Egea, JuditAguilera, LauraPerdomo, Juan ManuelPelaez, AmaiaLópez-Baamonde, ManuelNavarro Ripoll, RicardGimeno, ElenaCampero, BetinaTorné Bladé, AureliMartínez Palli, GracielaArguis Giménez, María JoséCàncer d'ovariCirurgia ginecològicaQuimioteràpia del càncerMalalts de càncerOvarian cancerGynecologic surgeryCancer chemotherapyCancer patientsIntroduction: Treatment for advanced ovarian cancer (AOC) comprises cytoreductive surgery combined with chemotherapy. Multimodal prehabilitation programmes before surgery have demonstrated efficacy in postoperative outcomes in non-gynaecological surgeries. However, the viability and effects of these programmes on patients with AOC are unknown. We aimed to evaluate the feasibility and postoperative impact of a multimodal prehabilitation programme in AOC patients undergoing surgery. Methods: This single-centre, before-and-after intervention pilot study included 34 patients in two cohorts: the prehabilitation cohort prospectively included 15 patients receiving supervised exercise, nutritional optimisation, and psychological preparation from December 2019 to January 2021; the control cohort included 19 consecutive patients between January 2018 and November 2019. Enhanced Recovery After Surgery guidelines were followed. Results: The overall adherence to the multimodal prehabilitation programme was 80%, with 86.7% adherence to exercise training, 100% adherence to nutritional optimisation, and 80% adherence to psychological preparation. The median hospital stay was shorter in the prehabilitation cohort (5 (IQR, 4-6) vs. 7 days (IQR, 5-9) in the control cohort, p = 0.04). Differences in postoperative complications using the comprehensive complication index (CCI) were not significant (CCI score: 9.3 (SD 12.12) in the prehabilitation cohort vs. 16.61 (SD 16.89) in the control cohort, p = 0.08). The median time to starting chemotherapy was shorter in the prehabilitation cohort (25 (IQR, 23-25) vs. 35 days (IQR, 28-45) in the control cohort, p = 0.03). Conclusions: A multimodal prehabilitation programme before cytoreductive surgery is feasible in AOC patients with no major adverse effects, and results in significantly shorter hospital stays and time to starting chemotherapy.MDPI2023202320222023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion12 p.application/pdfhttps://hdl.handle.net/2445/195560Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/cancers14071635Cancers, 2022, vol. 14, num. 7, p. 1635https://doi.org/10.3390/cancers14071635cc-by (c) Díaz Feijoo, Berta et al., 2022https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1955602026-05-29T05:05:01Z
dc.title.none.fl_str_mv Feasibility of a Multimodal Prehabilitation Programme in Patients Undergoing Cytoreductive Surgery for Advanced Ovarian Cancer: A Pilot Study
title Feasibility of a Multimodal Prehabilitation Programme in Patients Undergoing Cytoreductive Surgery for Advanced Ovarian Cancer: A Pilot Study
spellingShingle Feasibility of a Multimodal Prehabilitation Programme in Patients Undergoing Cytoreductive Surgery for Advanced Ovarian Cancer: A Pilot Study
Díaz Feijoo, Berta
Càncer d'ovari
Cirurgia ginecològica
Quimioteràpia del càncer
Malalts de càncer
Ovarian cancer
Gynecologic surgery
Cancer chemotherapy
Cancer patients
title_short Feasibility of a Multimodal Prehabilitation Programme in Patients Undergoing Cytoreductive Surgery for Advanced Ovarian Cancer: A Pilot Study
title_full Feasibility of a Multimodal Prehabilitation Programme in Patients Undergoing Cytoreductive Surgery for Advanced Ovarian Cancer: A Pilot Study
title_fullStr Feasibility of a Multimodal Prehabilitation Programme in Patients Undergoing Cytoreductive Surgery for Advanced Ovarian Cancer: A Pilot Study
title_full_unstemmed Feasibility of a Multimodal Prehabilitation Programme in Patients Undergoing Cytoreductive Surgery for Advanced Ovarian Cancer: A Pilot Study
title_sort Feasibility of a Multimodal Prehabilitation Programme in Patients Undergoing Cytoreductive Surgery for Advanced Ovarian Cancer: A Pilot Study
dc.creator.none.fl_str_mv Díaz Feijoo, Berta
Agustí, Núria
Sebio García, Raquel
López-Hernández, Antonio
Siso, Marina
Glickman, Ariel
Carreras Dieguez, Núria
Fusté, Pere
Marina, Tiermes
Martínez-Egea, Judit
Aguilera, Laura
Perdomo, Juan Manuel
Pelaez, Amaia
López-Baamonde, Manuel
Navarro Ripoll, Ricard
Gimeno, Elena
Campero, Betina
Torné Bladé, Aureli
Martínez Palli, Graciela
Arguis Giménez, María José
author Díaz Feijoo, Berta
author_facet Díaz Feijoo, Berta
Agustí, Núria
Sebio García, Raquel
López-Hernández, Antonio
Siso, Marina
Glickman, Ariel
Carreras Dieguez, Núria
Fusté, Pere
Marina, Tiermes
Martínez-Egea, Judit
Aguilera, Laura
Perdomo, Juan Manuel
Pelaez, Amaia
López-Baamonde, Manuel
Navarro Ripoll, Ricard
Gimeno, Elena
Campero, Betina
Torné Bladé, Aureli
Martínez Palli, Graciela
Arguis Giménez, María José
author_role author
author2 Agustí, Núria
Sebio García, Raquel
López-Hernández, Antonio
Siso, Marina
Glickman, Ariel
Carreras Dieguez, Núria
Fusté, Pere
Marina, Tiermes
Martínez-Egea, Judit
Aguilera, Laura
Perdomo, Juan Manuel
Pelaez, Amaia
López-Baamonde, Manuel
Navarro Ripoll, Ricard
Gimeno, Elena
Campero, Betina
Torné Bladé, Aureli
Martínez Palli, Graciela
Arguis Giménez, María José
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Càncer d'ovari
Cirurgia ginecològica
Quimioteràpia del càncer
Malalts de càncer
Ovarian cancer
Gynecologic surgery
Cancer chemotherapy
Cancer patients
topic Càncer d'ovari
Cirurgia ginecològica
Quimioteràpia del càncer
Malalts de càncer
Ovarian cancer
Gynecologic surgery
Cancer chemotherapy
Cancer patients
description Introduction: Treatment for advanced ovarian cancer (AOC) comprises cytoreductive surgery combined with chemotherapy. Multimodal prehabilitation programmes before surgery have demonstrated efficacy in postoperative outcomes in non-gynaecological surgeries. However, the viability and effects of these programmes on patients with AOC are unknown. We aimed to evaluate the feasibility and postoperative impact of a multimodal prehabilitation programme in AOC patients undergoing surgery. Methods: This single-centre, before-and-after intervention pilot study included 34 patients in two cohorts: the prehabilitation cohort prospectively included 15 patients receiving supervised exercise, nutritional optimisation, and psychological preparation from December 2019 to January 2021; the control cohort included 19 consecutive patients between January 2018 and November 2019. Enhanced Recovery After Surgery guidelines were followed. Results: The overall adherence to the multimodal prehabilitation programme was 80%, with 86.7% adherence to exercise training, 100% adherence to nutritional optimisation, and 80% adherence to psychological preparation. The median hospital stay was shorter in the prehabilitation cohort (5 (IQR, 4-6) vs. 7 days (IQR, 5-9) in the control cohort, p = 0.04). Differences in postoperative complications using the comprehensive complication index (CCI) were not significant (CCI score: 9.3 (SD 12.12) in the prehabilitation cohort vs. 16.61 (SD 16.89) in the control cohort, p = 0.08). The median time to starting chemotherapy was shorter in the prehabilitation cohort (25 (IQR, 23-25) vs. 35 days (IQR, 28-45) in the control cohort, p = 0.03). Conclusions: A multimodal prehabilitation programme before cytoreductive surgery is feasible in AOC patients with no major adverse effects, and results in significantly shorter hospital stays and time to starting chemotherapy.
publishDate 2022
dc.date.none.fl_str_mv 2022
2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/195560
url https://hdl.handle.net/2445/195560
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/cancers14071635
Cancers, 2022, vol. 14, num. 7, p. 1635
https://doi.org/10.3390/cancers14071635
dc.rights.none.fl_str_mv cc-by (c) Díaz Feijoo, Berta et al., 2022
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Díaz Feijoo, Berta et al., 2022
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 12 p.
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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