Impact of antibiotics, corticosteroids, and microbiota on immunotherapy efficacy in patients with non-small cell lung cancer

8 figures, 2 tables.

Detalles Bibliográficos
Autores: Zapata, María, Moratiel-Pellitero, Alba, Isla, Dolores, Gálvez Buerba, Eva Mª, Gascón, Marta, Sesma, Andrea, Barbero-Herranz, Raquel, Galeano, Javier, Campo, Rosa del, Ocáriz, Maitane, Quílez, Elisa, Cruellas, Mara, Ramírez-Labrada, Ariel, Pardo, Julián, Martínez Lostao, Luis, Domingo, María Pilar, Esteban, Patricia, Torres-Ramón, Irene, Yubero, Alfonso, Paño, José Ramón, Lastra, Rodrigo
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/363428
Acceso en línea:http://hdl.handle.net/10261/363428
Access Level:acceso abierto
Palabra clave:Lung cancer
Immunotherapy
Airway microbiota
Antibiotics
Corticosteroids
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
Immunology
Microbiology
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oai_identifier_str oai:digital.csic.es:10261/363428
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Impact of antibiotics, corticosteroids, and microbiota on immunotherapy efficacy in patients with non-small cell lung cancer
title Impact of antibiotics, corticosteroids, and microbiota on immunotherapy efficacy in patients with non-small cell lung cancer
spellingShingle Impact of antibiotics, corticosteroids, and microbiota on immunotherapy efficacy in patients with non-small cell lung cancer
Zapata, María
Lung cancer
Immunotherapy
Airway microbiota
Antibiotics
Corticosteroids
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
Immunology
Microbiology
title_short Impact of antibiotics, corticosteroids, and microbiota on immunotherapy efficacy in patients with non-small cell lung cancer
title_full Impact of antibiotics, corticosteroids, and microbiota on immunotherapy efficacy in patients with non-small cell lung cancer
title_fullStr Impact of antibiotics, corticosteroids, and microbiota on immunotherapy efficacy in patients with non-small cell lung cancer
title_full_unstemmed Impact of antibiotics, corticosteroids, and microbiota on immunotherapy efficacy in patients with non-small cell lung cancer
title_sort Impact of antibiotics, corticosteroids, and microbiota on immunotherapy efficacy in patients with non-small cell lung cancer
dc.creator.none.fl_str_mv Zapata, María
Moratiel-Pellitero, Alba
Isla, Dolores
Gálvez Buerba, Eva Mª
Gascón, Marta
Sesma, Andrea
Barbero-Herranz, Raquel
Galeano, Javier
Campo, Rosa del
Ocáriz, Maitane
Quílez, Elisa
Cruellas, Mara
Ramírez-Labrada, Ariel
Pardo, Julián
Martínez Lostao, Luis
Domingo, María Pilar
Esteban, Patricia
Torres-Ramón, Irene
Yubero, Alfonso
Paño, José Ramón
Lastra, Rodrigo
author Zapata, María
author_facet Zapata, María
Moratiel-Pellitero, Alba
Isla, Dolores
Gálvez Buerba, Eva Mª
Gascón, Marta
Sesma, Andrea
Barbero-Herranz, Raquel
Galeano, Javier
Campo, Rosa del
Ocáriz, Maitane
Quílez, Elisa
Cruellas, Mara
Ramírez-Labrada, Ariel
Pardo, Julián
Martínez Lostao, Luis
Domingo, María Pilar
Esteban, Patricia
Torres-Ramón, Irene
Yubero, Alfonso
Paño, José Ramón
Lastra, Rodrigo
author_role author
author2 Moratiel-Pellitero, Alba
Isla, Dolores
Gálvez Buerba, Eva Mª
Gascón, Marta
Sesma, Andrea
Barbero-Herranz, Raquel
Galeano, Javier
Campo, Rosa del
Ocáriz, Maitane
Quílez, Elisa
Cruellas, Mara
Ramírez-Labrada, Ariel
Pardo, Julián
Martínez Lostao, Luis
Domingo, María Pilar
Esteban, Patricia
Torres-Ramón, Irene
Yubero, Alfonso
Paño, José Ramón
Lastra, Rodrigo
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Instituto de Salud Carlos III
Ministerio de Ciencia e Innovación (España)
European Commission
Gobierno de Aragón
Agencia Estatal de Investigación (España)
Zapata, María [0000-0001-6654-8106]
Moratiel-Pellitero, Alba [0009-0000-9486-6793]
Isla, Dolores [0000-0002-2483-198X]
Gálvez Buerba, Eva Mª [0000-0001-6928-5516]
Gascón, Marta [0000-0002-6811-6654]
Sesma, Andrea [0000-0001-7209-266X]
Barbero-Herranz, Raquel [0000-0001-8845-1137]
Galeano, Javier [0000-0003-0706-4317]
Campo, Rosa del [0000-0003-1147-7923]
Ocáriz, Maitane [0000-0002-7557-7264]
Cruellas, Mara [0000-0002-6953-9675]
Ramírez-Labrada, Ariel [0000-0002-3888-7036]
Pardo, Julián [0000-0003-0154-0730]
Martínez Lostao, Luis [0000-0003-3043-147X]
Domingo, María Pilar [0000-0002-6829-8769]
Esteban, Patricia [0000-0003-4123-3524]
Torres-Ramón, Irene [0000-0003-3387-0558]
Yubero, Alfonso [0000-0003-4995-0325]
Paño, José Ramón [0000-0002-9600-8116]
Lastra, Rodrigo [0000-0002-7498-7798]
Zapata, María [maria.zapata.garcia.93@gmail.com]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Lung cancer
Immunotherapy
Airway microbiota
Antibiotics
Corticosteroids
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
Immunology
Microbiology
topic Lung cancer
Immunotherapy
Airway microbiota
Antibiotics
Corticosteroids
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
Immunology
Microbiology
description 8 figures, 2 tables.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/363428
url http://hdl.handle.net/10261/363428
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-113963RB-I00
http://dx.doi.org/10.1016/j.heliyon.2024.e33684
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869422638134198272
spelling Impact of antibiotics, corticosteroids, and microbiota on immunotherapy efficacy in patients with non-small cell lung cancerZapata, MaríaMoratiel-Pellitero, AlbaIsla, DoloresGálvez Buerba, Eva MªGascón, MartaSesma, AndreaBarbero-Herranz, RaquelGaleano, JavierCampo, Rosa delOcáriz, MaitaneQuílez, ElisaCruellas, MaraRamírez-Labrada, ArielPardo, JuliánMartínez Lostao, LuisDomingo, María PilarEsteban, PatriciaTorres-Ramón, IreneYubero, AlfonsoPaño, José RamónLastra, RodrigoLung cancerImmunotherapyAirway microbiotaAntibioticsCorticosteroidshttp://metadata.un.org/sdg/3Ensure healthy lives and promote well-being for all at all agesImmunologyMicrobiology8 figures, 2 tables.Lung cancer is a leading cause of morbidity and mortality globally, with its high mortality rate attributed mainly to non-small cell lung cancer (NSCLC). Although immunotherapy with immune checkpoint inhibitors (ICI) has revolutionized its treatment, patient response is highly variable and lacking predictive markers. We conducted a prospective study on 55 patients with NSCLC undergoing ICI therapy to identify predictive markers of both response and immune-related adverse events (IrAEs) in the airway microbiota. We also analyzed the clinical evolution and overall survival (OS) with respect to treatments that affect the integrity of the microbiota, such as antibiotics and corticosteroids. Our results demonstrated that respiratory microbiota differ significantly in ICI responders: they have higher alpha diversity values and lower abundance of the Firmicutes phylum and the Streptococcus genus. Employing a logistic regression model, the abundance of Gemella was the major predictor of non-ICI response, whereas Lachnoanaerobaculum was the best predictor of a positive response to ICI. The most relevant results were that antibiotic consumption is linked to a lower ICI response, and the use of corticosteroids correlated with poorer overall survival. Whereas previous studies have focused on gut microbiota, our findings highlight the importance of the respiratory microbiota in predicting the treatment response. Future research should explore microbiota modulation strategies to enhance immunotherapy outcomes. Understanding the impact of antibiotics, corticosteroids, and microbiota on NSCLC immunotherapy will help personalize treatment and improve patient outcomes.This research was supported by CIBER - Consorcio Centro de Investigación Biomédica en Red - (CB 2021), Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación and Unión Europea – NextGenerationEU, FEDER (Fondo Europeo de Desarrollo Regional), Gobierno de Aragón (Group B29_23R), Ministerio de Ciencia, Innovación e Universidades (MCNU), Agencia Estatal de Investigación (PID2020-113963RB-I00). It was also supported by a Personalized and Precision Medicine grant from the Instituto de Salud Carlos III (MePRAM Project, PMP22/00092), Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación, funded by NextGenerationEU funds from the European Union that finance the actions of the Resilience and Recovery Facility.Peer reviewedElsevierInstituto de Salud Carlos IIIMinisterio de Ciencia e Innovación (España)European CommissionGobierno de AragónAgencia Estatal de Investigación (España)Zapata, María [0000-0001-6654-8106]Moratiel-Pellitero, Alba [0009-0000-9486-6793]Isla, Dolores [0000-0002-2483-198X]Gálvez Buerba, Eva Mª [0000-0001-6928-5516]Gascón, Marta [0000-0002-6811-6654]Sesma, Andrea [0000-0001-7209-266X]Barbero-Herranz, Raquel [0000-0001-8845-1137]Galeano, Javier [0000-0003-0706-4317]Campo, Rosa del [0000-0003-1147-7923]Ocáriz, Maitane [0000-0002-7557-7264]Cruellas, Mara [0000-0002-6953-9675]Ramírez-Labrada, Ariel [0000-0002-3888-7036]Pardo, Julián [0000-0003-0154-0730]Martínez Lostao, Luis [0000-0003-3043-147X]Domingo, María Pilar [0000-0002-6829-8769]Esteban, Patricia [0000-0003-4123-3524]Torres-Ramón, Irene [0000-0003-3387-0558]Yubero, Alfonso [0000-0003-4995-0325]Paño, José Ramón [0000-0002-9600-8116]Lastra, Rodrigo [0000-0002-7498-7798]Zapata, María [maria.zapata.garcia.93@gmail.com]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/363428reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-113963RB-I00http://dx.doi.org/10.1016/j.heliyon.2024.e33684Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3634282026-05-22T06:33:51Z
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