Fish Skin Mucus Extracts: An Underexplored Source of Antimicrobial Agents

The slow discovery of new antibiotics combined with the alarming emergence of antibiotic-resistant bacteria underscores the need for alternative treatments. In this regard, fish skin mucus has been demonstrated to contain a diverse array of bioactive molecules with antimicrobial properties, includin...

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Detalles Bibliográficos
Autores: Díaz-Puertas, Rocío, Adamek, Mikolaj, Mallavia, Ricardo, Falcó, Alberto
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/375957
Acceso en línea:http://hdl.handle.net/10261/375957
Access Level:acceso abierto
Palabra clave:Marine organisms
Fish
Skin mucus
Extract
Antimicrobial
Antibacterial
Antifungal
Antiviral
Omics
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spelling Fish Skin Mucus Extracts: An Underexplored Source of Antimicrobial AgentsDíaz-Puertas, RocíoAdamek, MikolajMallavia, RicardoFalcó, AlbertoMarine organismsFishSkin mucusExtractAntimicrobialAntibacterialAntifungalAntiviralOmicsThe slow discovery of new antibiotics combined with the alarming emergence of antibiotic-resistant bacteria underscores the need for alternative treatments. In this regard, fish skin mucus has been demonstrated to contain a diverse array of bioactive molecules with antimicrobial properties, including peptides, proteins, and other metabolites. This review aims to provide an overview of the antimicrobial molecules found in fish skin mucus and its reported in vitro antimicrobial capacity against bacteria, fungi, and viruses. Additionally, the different methods of mucus extraction, which can be grouped as aqueous, organic, and acidic extractions, are presented. Finally, omic techniques (genomics, transcriptomics, proteomics, metabolomics, and multiomics) are described as key tools for the identification and isolation of new antimicrobial compounds. Overall, this study provides valuable insight into the potential of fish skin mucus as a promising source for the discovery of new antimicrobial agents.This research was funded by the FEDER/Spanish Ministry of Science, Innovation and Universities—State Agency of Research, grant number RTI2018-101969-J-I00, and the European Maritime, Fisheries and Aquaculture Fund (EMFAF) and the Ministry of Agriculture, Fisheries and Food (MAPA), grant number MetDisFish.Peer reviewedMultidisciplinary Digital Publishing InstituteEuropean CommissionMinisterio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)Fondo Europeo Marítimo, de Pesca y de AcuiculturaMinisterio de Agricultura, Pesca y Alimentación (España)202520252023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/375957reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-101969-J-I00The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.3390/md21060350https://doi.org/10.3390/md21060350Noinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3759572026-05-22T06:33:51Z
dc.title.none.fl_str_mv Fish Skin Mucus Extracts: An Underexplored Source of Antimicrobial Agents
title Fish Skin Mucus Extracts: An Underexplored Source of Antimicrobial Agents
spellingShingle Fish Skin Mucus Extracts: An Underexplored Source of Antimicrobial Agents
Díaz-Puertas, Rocío
Marine organisms
Fish
Skin mucus
Extract
Antimicrobial
Antibacterial
Antifungal
Antiviral
Omics
title_short Fish Skin Mucus Extracts: An Underexplored Source of Antimicrobial Agents
title_full Fish Skin Mucus Extracts: An Underexplored Source of Antimicrobial Agents
title_fullStr Fish Skin Mucus Extracts: An Underexplored Source of Antimicrobial Agents
title_full_unstemmed Fish Skin Mucus Extracts: An Underexplored Source of Antimicrobial Agents
title_sort Fish Skin Mucus Extracts: An Underexplored Source of Antimicrobial Agents
dc.creator.none.fl_str_mv Díaz-Puertas, Rocío
Adamek, Mikolaj
Mallavia, Ricardo
Falcó, Alberto
author Díaz-Puertas, Rocío
author_facet Díaz-Puertas, Rocío
Adamek, Mikolaj
Mallavia, Ricardo
Falcó, Alberto
author_role author
author2 Adamek, Mikolaj
Mallavia, Ricardo
Falcó, Alberto
author2_role author
author
author
dc.contributor.none.fl_str_mv European Commission
Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
Fondo Europeo Marítimo, de Pesca y de Acuicultura
Ministerio de Agricultura, Pesca y Alimentación (España)
dc.subject.none.fl_str_mv Marine organisms
Fish
Skin mucus
Extract
Antimicrobial
Antibacterial
Antifungal
Antiviral
Omics
topic Marine organisms
Fish
Skin mucus
Extract
Antimicrobial
Antibacterial
Antifungal
Antiviral
Omics
description The slow discovery of new antibiotics combined with the alarming emergence of antibiotic-resistant bacteria underscores the need for alternative treatments. In this regard, fish skin mucus has been demonstrated to contain a diverse array of bioactive molecules with antimicrobial properties, including peptides, proteins, and other metabolites. This review aims to provide an overview of the antimicrobial molecules found in fish skin mucus and its reported in vitro antimicrobial capacity against bacteria, fungi, and viruses. Additionally, the different methods of mucus extraction, which can be grouped as aqueous, organic, and acidic extractions, are presented. Finally, omic techniques (genomics, transcriptomics, proteomics, metabolomics, and multiomics) are described as key tools for the identification and isolation of new antimicrobial compounds. Overall, this study provides valuable insight into the potential of fish skin mucus as a promising source for the discovery of new antimicrobial agents.
publishDate 2023
dc.date.none.fl_str_mv 2023
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/375957
url http://hdl.handle.net/10261/375957
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-101969-J-I00
The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.3390/md21060350
https://doi.org/10.3390/md21060350
No
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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