Synthesis of a tetrahydroimidazo-[2',1':2,3]thiazolo[5,4-c]pyridine derivative with Met inhibitory activity

A straightforward synthesis of the Met antagonist JLK1360 involving an alkylationcyclocondensation process using aminothiazole 1 and nitrophenacyl bromide 2, reduction of the nitro group, and coupling of the resulting tetracyclic aniline 5 with an appropriate N-acyl alanine derivative, is reported.

Detalles Bibliográficos
Autores: Amat Tusón, Mercedes, Köver, Andrea, Jokic, Danica, Lozano, Oscar, Pérez Bosch, Maria, Landoni, Nicola, Subrizi, Fabiana, Bautista, Jesús, Bosch Cartes, Joan
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2010
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/61086
Acceso en línea:https://hdl.handle.net/2445/61086
Access Level:acceso abierto
Palabra clave:Bioquímica
Amines
Dianes farmacològiques
Proteïnes quinases
Transducció de senyal cel·lular
Biochemistry
Drug targeting
Protein kinases
Cellular signal transduction
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repository_id_str
spelling Synthesis of a tetrahydroimidazo-[2',1':2,3]thiazolo[5,4-c]pyridine derivative with Met inhibitory activityAmat Tusón, MercedesKöver, AndreaJokic, DanicaLozano, OscarPérez Bosch, MariaLandoni, NicolaSubrizi, FabianaBautista, JesúsBosch Cartes, JoanBioquímicaAminesDianes farmacològiquesProteïnes quinasesTransducció de senyal cel·lularBiochemistryAminesDrug targetingProtein kinasesCellular signal transductionA straightforward synthesis of the Met antagonist JLK1360 involving an alkylationcyclocondensation process using aminothiazole 1 and nitrophenacyl bromide 2, reduction of the nitro group, and coupling of the resulting tetracyclic aniline 5 with an appropriate N-acyl alanine derivative, is reported.Michigan Publishing2010info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/61086Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: http://dx.doi.org/10.3998/ark.5550190.0011.313Arkivoc, vol. 2010, núm. 3, p. 145-151http://dx.doi.org/10.3998/ark.5550190.0011.313cc-by-nc (c) Amat Tusón, Mercedes et al., 2010http://creativecommons.org/licenses/by-nc/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/610862026-05-27T06:46:51Z
dc.title.none.fl_str_mv Synthesis of a tetrahydroimidazo-[2',1':2,3]thiazolo[5,4-c]pyridine derivative with Met inhibitory activity
title Synthesis of a tetrahydroimidazo-[2',1':2,3]thiazolo[5,4-c]pyridine derivative with Met inhibitory activity
spellingShingle Synthesis of a tetrahydroimidazo-[2',1':2,3]thiazolo[5,4-c]pyridine derivative with Met inhibitory activity
Amat Tusón, Mercedes
Bioquímica
Amines
Dianes farmacològiques
Proteïnes quinases
Transducció de senyal cel·lular
Biochemistry
Amines
Drug targeting
Protein kinases
Cellular signal transduction
title_short Synthesis of a tetrahydroimidazo-[2',1':2,3]thiazolo[5,4-c]pyridine derivative with Met inhibitory activity
title_full Synthesis of a tetrahydroimidazo-[2',1':2,3]thiazolo[5,4-c]pyridine derivative with Met inhibitory activity
title_fullStr Synthesis of a tetrahydroimidazo-[2',1':2,3]thiazolo[5,4-c]pyridine derivative with Met inhibitory activity
title_full_unstemmed Synthesis of a tetrahydroimidazo-[2',1':2,3]thiazolo[5,4-c]pyridine derivative with Met inhibitory activity
title_sort Synthesis of a tetrahydroimidazo-[2',1':2,3]thiazolo[5,4-c]pyridine derivative with Met inhibitory activity
dc.creator.none.fl_str_mv Amat Tusón, Mercedes
Köver, Andrea
Jokic, Danica
Lozano, Oscar
Pérez Bosch, Maria
Landoni, Nicola
Subrizi, Fabiana
Bautista, Jesús
Bosch Cartes, Joan
author Amat Tusón, Mercedes
author_facet Amat Tusón, Mercedes
Köver, Andrea
Jokic, Danica
Lozano, Oscar
Pérez Bosch, Maria
Landoni, Nicola
Subrizi, Fabiana
Bautista, Jesús
Bosch Cartes, Joan
author_role author
author2 Köver, Andrea
Jokic, Danica
Lozano, Oscar
Pérez Bosch, Maria
Landoni, Nicola
Subrizi, Fabiana
Bautista, Jesús
Bosch Cartes, Joan
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Bioquímica
Amines
Dianes farmacològiques
Proteïnes quinases
Transducció de senyal cel·lular
Biochemistry
Amines
Drug targeting
Protein kinases
Cellular signal transduction
topic Bioquímica
Amines
Dianes farmacològiques
Proteïnes quinases
Transducció de senyal cel·lular
Biochemistry
Amines
Drug targeting
Protein kinases
Cellular signal transduction
description A straightforward synthesis of the Met antagonist JLK1360 involving an alkylationcyclocondensation process using aminothiazole 1 and nitrophenacyl bromide 2, reduction of the nitro group, and coupling of the resulting tetracyclic aniline 5 with an appropriate N-acyl alanine derivative, is reported.
publishDate 2010
dc.date.none.fl_str_mv 2010
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/61086
url https://hdl.handle.net/2445/61086
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://dx.doi.org/10.3998/ark.5550190.0011.313
Arkivoc, vol. 2010, núm. 3, p. 145-151
http://dx.doi.org/10.3998/ark.5550190.0011.313
dc.rights.none.fl_str_mv cc-by-nc (c) Amat Tusón, Mercedes et al., 2010
http://creativecommons.org/licenses/by-nc/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc (c) Amat Tusón, Mercedes et al., 2010
http://creativecommons.org/licenses/by-nc/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Michigan Publishing
publisher.none.fl_str_mv Michigan Publishing
dc.source.none.fl_str_mv Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869422635870322689
score 15,300724

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