Role of Omentin, Vaspin, Cardiotrophin-1, TWEAK and NOV/CCN3 in Obesity and Diabetes Development

Adipose tissue releases bioactive mediators called adipokines. This review focuses on the effects of omentin, vaspin, cardiotrophin-1, Tumor necrosis factor-like Weak Inducer of Apoptosis (TWEAK) and nephroblastoma overexpressed (NOV/CCN3) on obesity and diabetes. Omentin is produced by the stromal-...

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Autores: Escoté, Xabier, Gómez Zorita, Saioa, López Yoldi, Miguel, Milton Laskibar, Iñaki, Fernández Quintela, Alfredo, Martínez, José Alfredo, Moreno Aliaga, María J., Portillo Baquedano, María Puy
Tipo de recurso: capítulo de libro
Fecha de publicación:2017
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/30653
Acceso en línea:http://hdl.handle.net/10810/30653
Access Level:acceso abierto
Palabra clave:adipokines
omentin
vaspin
cardiotrophin-1
TWEAK and NOV
CCN3
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spelling Role of Omentin, Vaspin, Cardiotrophin-1, TWEAK and NOV/CCN3 in Obesity and Diabetes DevelopmentEscoté, XabierGómez Zorita, SaioaLópez Yoldi, MiguelMilton Laskibar, IñakiFernández Quintela, AlfredoMartínez, José AlfredoMoreno Aliaga, María J.Portillo Baquedano, María Puyadipokinesomentinvaspincardiotrophin-1TWEAK and NOVCCN3Adipose tissue releases bioactive mediators called adipokines. This review focuses on the effects of omentin, vaspin, cardiotrophin-1, Tumor necrosis factor-like Weak Inducer of Apoptosis (TWEAK) and nephroblastoma overexpressed (NOV/CCN3) on obesity and diabetes. Omentin is produced by the stromal-vascular fraction of visceral adipose tissue. Obesity reduces omentin serum concentrations and adipose tissue secretion in adults and adolescents. This adipokine regulates insulin sensitivity, but its clinical relevance has to be confirmed. Vaspin is produced by visceral and subcutaneous adipose tissues. Vaspin levels are higher in obese subjects, as well as in subjects showing insulin resistance or type 2 diabetes. Cardiotrophin-1 is an adipokine with a similar structure as cytokines from interleukin-6 family. There is some controversy regarding the regulation of cardiotrophin-1 levels in obese -subjects, but gene expression levels of cardiotrophin-1 are down-regulated in white adipose tissue from diet-induced obese mice. It also shows anti-obesity and hypoglycemic properties. TWEAK is a potential regulator of the low-grade chronic inflammation characteristic of obesity. TWEAK levels seem not to be directly related to adiposity, and metabolic factors play a critical role in its regulation. Finally, a strong correlation has been found between plasma NOV/CCN3 concentration and fat mass. This adipokine improves insulin actions.This study was supported by grants from the Ministerio de Economia y Competitividad (AGL-2015-65719-FEDER-UE and BFU2015-65937-R), Government of the Basque Country (IT-572-13), University of the Basque Country (UPV/EHU) (ELDUNANOTEK UFI11/32), Linea Especial about Nutrition, Obesity and Health from the University of Navarra LE/97, Department of Health, Government of Navarra (67-2015) and Instituto de Salud Carlos III (CIBERobn). I. Milton-Laskibar is a PhD fellowship from the Basque Government and S. Gomez-Zorita is a post-doc fellowship from CIBERobn.MDPI201920192017info:eu-repo/semantics/bookPartapplication/pdfhttp://hdl.handle.net/10810/30653reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoInglésinfo:eu-repo/grantAgreement/MINECO/AGL-2015-65719-FEDER-UE/info:eu-repo/grantAgreement/MINECO/BFU2015-65937-R/https://www.mdpi.com/1422-0067/18/8/1770info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/3.0/es/© 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).Atribución 3.0 Españaoai:addi.ehu.eus:10810/306532026-06-18T09:23:17Z
dc.title.none.fl_str_mv Role of Omentin, Vaspin, Cardiotrophin-1, TWEAK and NOV/CCN3 in Obesity and Diabetes Development
title Role of Omentin, Vaspin, Cardiotrophin-1, TWEAK and NOV/CCN3 in Obesity and Diabetes Development
spellingShingle Role of Omentin, Vaspin, Cardiotrophin-1, TWEAK and NOV/CCN3 in Obesity and Diabetes Development
Escoté, Xabier
adipokines
omentin
vaspin
cardiotrophin-1
TWEAK and NOV
CCN3
title_short Role of Omentin, Vaspin, Cardiotrophin-1, TWEAK and NOV/CCN3 in Obesity and Diabetes Development
title_full Role of Omentin, Vaspin, Cardiotrophin-1, TWEAK and NOV/CCN3 in Obesity and Diabetes Development
title_fullStr Role of Omentin, Vaspin, Cardiotrophin-1, TWEAK and NOV/CCN3 in Obesity and Diabetes Development
title_full_unstemmed Role of Omentin, Vaspin, Cardiotrophin-1, TWEAK and NOV/CCN3 in Obesity and Diabetes Development
title_sort Role of Omentin, Vaspin, Cardiotrophin-1, TWEAK and NOV/CCN3 in Obesity and Diabetes Development
dc.creator.none.fl_str_mv Escoté, Xabier
Gómez Zorita, Saioa
López Yoldi, Miguel
Milton Laskibar, Iñaki
Fernández Quintela, Alfredo
Martínez, José Alfredo
Moreno Aliaga, María J.
Portillo Baquedano, María Puy
author Escoté, Xabier
author_facet Escoté, Xabier
Gómez Zorita, Saioa
López Yoldi, Miguel
Milton Laskibar, Iñaki
Fernández Quintela, Alfredo
Martínez, José Alfredo
Moreno Aliaga, María J.
Portillo Baquedano, María Puy
author_role author
author2 Gómez Zorita, Saioa
López Yoldi, Miguel
Milton Laskibar, Iñaki
Fernández Quintela, Alfredo
Martínez, José Alfredo
Moreno Aliaga, María J.
Portillo Baquedano, María Puy
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv adipokines
omentin
vaspin
cardiotrophin-1
TWEAK and NOV
CCN3
topic adipokines
omentin
vaspin
cardiotrophin-1
TWEAK and NOV
CCN3
description Adipose tissue releases bioactive mediators called adipokines. This review focuses on the effects of omentin, vaspin, cardiotrophin-1, Tumor necrosis factor-like Weak Inducer of Apoptosis (TWEAK) and nephroblastoma overexpressed (NOV/CCN3) on obesity and diabetes. Omentin is produced by the stromal-vascular fraction of visceral adipose tissue. Obesity reduces omentin serum concentrations and adipose tissue secretion in adults and adolescents. This adipokine regulates insulin sensitivity, but its clinical relevance has to be confirmed. Vaspin is produced by visceral and subcutaneous adipose tissues. Vaspin levels are higher in obese subjects, as well as in subjects showing insulin resistance or type 2 diabetes. Cardiotrophin-1 is an adipokine with a similar structure as cytokines from interleukin-6 family. There is some controversy regarding the regulation of cardiotrophin-1 levels in obese -subjects, but gene expression levels of cardiotrophin-1 are down-regulated in white adipose tissue from diet-induced obese mice. It also shows anti-obesity and hypoglycemic properties. TWEAK is a potential regulator of the low-grade chronic inflammation characteristic of obesity. TWEAK levels seem not to be directly related to adiposity, and metabolic factors play a critical role in its regulation. Finally, a strong correlation has been found between plasma NOV/CCN3 concentration and fat mass. This adipokine improves insulin actions.
publishDate 2017
dc.date.none.fl_str_mv 2017
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/bookPart
format bookPart
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/30653
url http://hdl.handle.net/10810/30653
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/MINECO/AGL-2015-65719-FEDER-UE/
info:eu-repo/grantAgreement/MINECO/BFU2015-65937-R/
https://www.mdpi.com/1422-0067/18/8/1770
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/es/
Atribución 3.0 España
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/3.0/es/
Atribución 3.0 España
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
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