A Comprehensive Analysis of the Abdominal Aortic Aneurysm Growth Rate in the Spanish Population

Objective: The risk of Abdominal Aortic Aneurysm (AAA) rupture is associated with the aneurysm size and growth rate. This study aims to provide a global description of growth rates per intervals of AAA diameter size for individuals in the Spanish population, to understand possible comorbidities asso...

Descripción completa

Detalles Bibliográficos
Autores: Peypoch, O, Juscafresa, LC, Vega-Méndez, A, Lobato-Delgado, B, Fité, J, Soto, B, Nieto, L, Estadella, MD, Uribezubia, A, Romero, JM, Plana, E, Miralles, M, Clarà, A, Dilmé, J, Soria, JM, Camacho, M, Martinez-Perez, A, Sabater-Lleal, M
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p19767
Acceso en línea:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19767
Access Level:acceso abierto
Palabra clave:Abdominal Aortic Aneurysm (AAA)
risk prediction models
AAA screening
risk factors
id ES_e4daf5ea3a414410fcab737c9004e38f
oai_identifier_str oai:iibsantpau.fundanetsuite.com:p19767
network_acronym_str ES
network_name_str España
repository_id_str
spelling A Comprehensive Analysis of the Abdominal Aortic Aneurysm Growth Rate in the Spanish PopulationPeypoch, OJuscafresa, LCVega-Méndez, ALobato-Delgado, BFité, JSoto, BNieto, LEstadella, MDUribezubia, ARomero, JMPlana, EMiralles, MClarà, ADilmé, JSoria, JMCamacho, MMartinez-Perez, ASabater-Lleal, MAbdominal Aortic Aneurysm (AAA)risk prediction modelsAAA screeningrisk factorsObjective: The risk of Abdominal Aortic Aneurysm (AAA) rupture is associated with the aneurysm size and growth rate. This study aims to provide a global description of growth rates per intervals of AAA diameter size for individuals in the Spanish population, to understand possible comorbidities associated with growth rate variability, and to assess practitioners on safe follow-up visits for AAA patients. Methods: We present the Triple-A Barcelona Study (TABS), a new hospital-based longitudinal study recruiting consecutive individuals with AAAs in Barcelona. So far, 469 individuals with measurements of the abdominal aortic diameter, along with anthropometric, clinical information, and blood samples for most follow-up visits, have been recruited. Statistical modeling was performed to identify the most relevant predictors of the diameter size and expansion in individuals with AAAs using linear mixed-effect models. Results: The average growth rate per interval was 0.78 (2.34) mm/year for aneurysms with an initial diameter between 30 and 40 mm, 1.22 (3.34) mm/year for aneurysms with an initial diameter between 40 and 50 mm, and 4.12 (5.09) mm/year for aneurysms with an initial diameter equal to or greater than 50 mm. The main factors determining the growth rate beyond the aortic diameter are sex and related comorbidities (COPD and DM). The estimated time to reach the surgical threshold for individuals with small aneurysms exceeded 10 years, on average. Conclusions: Overall, this study serves as a promising step towards the development of better prediction tools to assess clinical decisions in AAA patients in the Spanish population and to guide future screening policies.MDPI2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19767Journal of Clinical MedicineISSN: 20770383reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p197672026-06-14T12:41:47Z
dc.title.none.fl_str_mv A Comprehensive Analysis of the Abdominal Aortic Aneurysm Growth Rate in the Spanish Population
title A Comprehensive Analysis of the Abdominal Aortic Aneurysm Growth Rate in the Spanish Population
spellingShingle A Comprehensive Analysis of the Abdominal Aortic Aneurysm Growth Rate in the Spanish Population
Peypoch, O
Abdominal Aortic Aneurysm (AAA)
risk prediction models
AAA screening
risk factors
title_short A Comprehensive Analysis of the Abdominal Aortic Aneurysm Growth Rate in the Spanish Population
title_full A Comprehensive Analysis of the Abdominal Aortic Aneurysm Growth Rate in the Spanish Population
title_fullStr A Comprehensive Analysis of the Abdominal Aortic Aneurysm Growth Rate in the Spanish Population
title_full_unstemmed A Comprehensive Analysis of the Abdominal Aortic Aneurysm Growth Rate in the Spanish Population
title_sort A Comprehensive Analysis of the Abdominal Aortic Aneurysm Growth Rate in the Spanish Population
dc.creator.none.fl_str_mv Peypoch, O
Juscafresa, LC
Vega-Méndez, A
Lobato-Delgado, B
Fité, J
Soto, B
Nieto, L
Estadella, MD
Uribezubia, A
Romero, JM
Plana, E
Miralles, M
Clarà, A
Dilmé, J
Soria, JM
Camacho, M
Martinez-Perez, A
Sabater-Lleal, M
author Peypoch, O
author_facet Peypoch, O
Juscafresa, LC
Vega-Méndez, A
Lobato-Delgado, B
Fité, J
Soto, B
Nieto, L
Estadella, MD
Uribezubia, A
Romero, JM
Plana, E
Miralles, M
Clarà, A
Dilmé, J
Soria, JM
Camacho, M
Martinez-Perez, A
Sabater-Lleal, M
author_role author
author2 Juscafresa, LC
Vega-Méndez, A
Lobato-Delgado, B
Fité, J
Soto, B
Nieto, L
Estadella, MD
Uribezubia, A
Romero, JM
Plana, E
Miralles, M
Clarà, A
Dilmé, J
Soria, JM
Camacho, M
Martinez-Perez, A
Sabater-Lleal, M
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Abdominal Aortic Aneurysm (AAA)
risk prediction models
AAA screening
risk factors
topic Abdominal Aortic Aneurysm (AAA)
risk prediction models
AAA screening
risk factors
description Objective: The risk of Abdominal Aortic Aneurysm (AAA) rupture is associated with the aneurysm size and growth rate. This study aims to provide a global description of growth rates per intervals of AAA diameter size for individuals in the Spanish population, to understand possible comorbidities associated with growth rate variability, and to assess practitioners on safe follow-up visits for AAA patients. Methods: We present the Triple-A Barcelona Study (TABS), a new hospital-based longitudinal study recruiting consecutive individuals with AAAs in Barcelona. So far, 469 individuals with measurements of the abdominal aortic diameter, along with anthropometric, clinical information, and blood samples for most follow-up visits, have been recruited. Statistical modeling was performed to identify the most relevant predictors of the diameter size and expansion in individuals with AAAs using linear mixed-effect models. Results: The average growth rate per interval was 0.78 (2.34) mm/year for aneurysms with an initial diameter between 30 and 40 mm, 1.22 (3.34) mm/year for aneurysms with an initial diameter between 40 and 50 mm, and 4.12 (5.09) mm/year for aneurysms with an initial diameter equal to or greater than 50 mm. The main factors determining the growth rate beyond the aortic diameter are sex and related comorbidities (COPD and DM). The estimated time to reach the surgical threshold for individuals with small aneurysms exceeded 10 years, on average. Conclusions: Overall, this study serves as a promising step towards the development of better prediction tools to assess clinical decisions in AAA patients in the Spanish population and to guide future screening policies.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19767
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19767
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Journal of Clinical Medicine
ISSN: 20770383
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869422627892756480
score 15,811543

Similares en LA Referencia