Size Effects in Finite Element Modelling of 3D Printed Bone Scaffolds Using Hydroxyapatite PEOT/PBT Composites

Additive manufacturing (AM) of scaffolds enables the fabrication of customized patient-specific implants for tissue regeneration. Scaffold customization does not involve only the macroscale shape of the final implant, but also their microscopic pore geometry and material properties, which are depend...

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Autores: Calderón Uríszar-Aldaca, Iñigo, Pérez, Sergio, Sinha, Ravi, Camara-Torres, Maria, Villanueva Díez, Sara, Mota, Carlos Miguel Domingues, Patelli, Alessandro, Matanza Corro, Amaia, Moroni, Lorenzo, Sánchez, Alberto
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/52803
Acceso en línea:http://hdl.handle.net/10810/52803
Access Level:acceso abierto
Palabra clave:finite element modelling
bone tissue engineering
3D scaffold
additive manufacturing
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spelling Size Effects in Finite Element Modelling of 3D Printed Bone Scaffolds Using Hydroxyapatite PEOT/PBT CompositesCalderón Uríszar-Aldaca, IñigoPérez, SergioSinha, RaviCamara-Torres, MariaVillanueva Díez, SaraMota, Carlos Miguel DominguesPatelli, AlessandroMatanza Corro, AmaiaMoroni, LorenzoSánchez, Albertofinite element modellingbone tissue engineering3D scaffoldadditive manufacturingAdditive manufacturing (AM) of scaffolds enables the fabrication of customized patient-specific implants for tissue regeneration. Scaffold customization does not involve only the macroscale shape of the final implant, but also their microscopic pore geometry and material properties, which are dependent on optimizable topology. A good match between the experimental data of AM scaffolds and the models is obtained when there is just a few millimetres at least in one direction. Here, we describe a methodology to perform finite element modelling on AM scaffolds for bone tissue regeneration with clinically relevant dimensions (i.e., volume > 1 cm3). The simulation used an equivalent cubic eight node finite elements mesh, and the materials properties were derived both empirically and numerically, from bulk material direct testing and simulated tests on scaffolds. The experimental validation was performed using poly(ethylene oxide terephthalate)-poly(butylene terephthalate) (PEOT/PBT) copolymers and 45 wt% nano hydroxyapatite fillers composites. By applying this methodology on three separate scaffold architectures with volumes larger than 1 cm3, the simulations overestimated the scaffold performance, resulting in 150–290% stiffer than average values obtained in the validation tests. The results mismatch highlighted the relevance of the lack of printing accuracy that is characteristic of the additive manufacturing process. Accordingly, a sensitivity analysis was performed on nine detected uncertainty sources, studying their influence. After the definition of acceptable execution tolerances and reliability levels, a design factor was defined to calibrate the methodology under expectable and conservative scenarios.This research was funded by the European Union, represented by the European Commission, grant number 685825-FAST-H2020-NMP-2014-2015/H2020-NMP-PILOTS-2015.MDPIEuropean Commission2021202120212021info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/52803reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoInglésinfo:eu-repo/grantAgreement/EC/H2020/685825https://www.mdpi.com/2227-7390/9/15/1746/htminfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/3.0/es/2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).oai:addi.ehu.eus:10810/528032026-06-18T09:23:17Z
dc.title.none.fl_str_mv Size Effects in Finite Element Modelling of 3D Printed Bone Scaffolds Using Hydroxyapatite PEOT/PBT Composites
title Size Effects in Finite Element Modelling of 3D Printed Bone Scaffolds Using Hydroxyapatite PEOT/PBT Composites
spellingShingle Size Effects in Finite Element Modelling of 3D Printed Bone Scaffolds Using Hydroxyapatite PEOT/PBT Composites
Calderón Uríszar-Aldaca, Iñigo
finite element modelling
bone tissue engineering
3D scaffold
additive manufacturing
title_short Size Effects in Finite Element Modelling of 3D Printed Bone Scaffolds Using Hydroxyapatite PEOT/PBT Composites
title_full Size Effects in Finite Element Modelling of 3D Printed Bone Scaffolds Using Hydroxyapatite PEOT/PBT Composites
title_fullStr Size Effects in Finite Element Modelling of 3D Printed Bone Scaffolds Using Hydroxyapatite PEOT/PBT Composites
title_full_unstemmed Size Effects in Finite Element Modelling of 3D Printed Bone Scaffolds Using Hydroxyapatite PEOT/PBT Composites
title_sort Size Effects in Finite Element Modelling of 3D Printed Bone Scaffolds Using Hydroxyapatite PEOT/PBT Composites
dc.creator.none.fl_str_mv Calderón Uríszar-Aldaca, Iñigo
Pérez, Sergio
Sinha, Ravi
Camara-Torres, Maria
Villanueva Díez, Sara
Mota, Carlos Miguel Domingues
Patelli, Alessandro
Matanza Corro, Amaia
Moroni, Lorenzo
Sánchez, Alberto
author Calderón Uríszar-Aldaca, Iñigo
author_facet Calderón Uríszar-Aldaca, Iñigo
Pérez, Sergio
Sinha, Ravi
Camara-Torres, Maria
Villanueva Díez, Sara
Mota, Carlos Miguel Domingues
Patelli, Alessandro
Matanza Corro, Amaia
Moroni, Lorenzo
Sánchez, Alberto
author_role author
author2 Pérez, Sergio
Sinha, Ravi
Camara-Torres, Maria
Villanueva Díez, Sara
Mota, Carlos Miguel Domingues
Patelli, Alessandro
Matanza Corro, Amaia
Moroni, Lorenzo
Sánchez, Alberto
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv European Commission
dc.subject.none.fl_str_mv finite element modelling
bone tissue engineering
3D scaffold
additive manufacturing
topic finite element modelling
bone tissue engineering
3D scaffold
additive manufacturing
description Additive manufacturing (AM) of scaffolds enables the fabrication of customized patient-specific implants for tissue regeneration. Scaffold customization does not involve only the macroscale shape of the final implant, but also their microscopic pore geometry and material properties, which are dependent on optimizable topology. A good match between the experimental data of AM scaffolds and the models is obtained when there is just a few millimetres at least in one direction. Here, we describe a methodology to perform finite element modelling on AM scaffolds for bone tissue regeneration with clinically relevant dimensions (i.e., volume > 1 cm3). The simulation used an equivalent cubic eight node finite elements mesh, and the materials properties were derived both empirically and numerically, from bulk material direct testing and simulated tests on scaffolds. The experimental validation was performed using poly(ethylene oxide terephthalate)-poly(butylene terephthalate) (PEOT/PBT) copolymers and 45 wt% nano hydroxyapatite fillers composites. By applying this methodology on three separate scaffold architectures with volumes larger than 1 cm3, the simulations overestimated the scaffold performance, resulting in 150–290% stiffer than average values obtained in the validation tests. The results mismatch highlighted the relevance of the lack of printing accuracy that is characteristic of the additive manufacturing process. Accordingly, a sensitivity analysis was performed on nine detected uncertainty sources, studying their influence. After the definition of acceptable execution tolerances and reliability levels, a design factor was defined to calibrate the methodology under expectable and conservative scenarios.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/52803
url http://hdl.handle.net/10810/52803
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/EC/H2020/685825
https://www.mdpi.com/2227-7390/9/15/1746/htm
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/3.0/es/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
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