Molecular classification and biomarkers of clinical outcome in breast ductal carcinoma in situ: Analysis of TBCRC 038 and RAHBT cohorts

Ductal carcinoma in situ; Tumor microenvironment; Whole genome sequencing

Detalles Bibliográficos
Autores: Strand, Siri H, Rivero-Gutierrez, Belen, Houlahan, Kathleen, Seoane Fernández, Jose Antonio, King, Lorraine M., Risom, Tyler
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:11351/8732
Acceso en línea:https://hdl.handle.net/11351/8732
http://hdl.handle.net/11351/8732
Access Level:acceso abierto
Palabra clave:Marcadors tumorals
Mama - Càncer - Aspectes genètics
DISEASES::Neoplasms::Neoplasms by Site::Breast Neoplasms
Other subheadings::Other subheadings::Other subheadings::/genetics
CHEMICALS AND DRUGS::Biological Factors::Biomarkers::Biomarkers, Tumor
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de la mama
Otros calificadores::Otros calificadores::Otros calificadores::/genética
COMPUESTOS QUÍMICOS Y DROGAS::factores biológicos::biomarcadores::marcadores tumorales
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oai_identifier_str oai:recercat.cat:11351/8732
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Molecular classification and biomarkers of clinical outcome in breast ductal carcinoma in situ: Analysis of TBCRC 038 and RAHBT cohorts
title Molecular classification and biomarkers of clinical outcome in breast ductal carcinoma in situ: Analysis of TBCRC 038 and RAHBT cohorts
spellingShingle Molecular classification and biomarkers of clinical outcome in breast ductal carcinoma in situ: Analysis of TBCRC 038 and RAHBT cohorts
Strand, Siri H
Marcadors tumorals
Mama - Càncer - Aspectes genètics
DISEASES::Neoplasms::Neoplasms by Site::Breast Neoplasms
Other subheadings::Other subheadings::Other subheadings::/genetics
CHEMICALS AND DRUGS::Biological Factors::Biomarkers::Biomarkers, Tumor
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de la mama
Otros calificadores::Otros calificadores::Otros calificadores::/genética
COMPUESTOS QUÍMICOS Y DROGAS::factores biológicos::biomarcadores::marcadores tumorales
title_short Molecular classification and biomarkers of clinical outcome in breast ductal carcinoma in situ: Analysis of TBCRC 038 and RAHBT cohorts
title_full Molecular classification and biomarkers of clinical outcome in breast ductal carcinoma in situ: Analysis of TBCRC 038 and RAHBT cohorts
title_fullStr Molecular classification and biomarkers of clinical outcome in breast ductal carcinoma in situ: Analysis of TBCRC 038 and RAHBT cohorts
title_full_unstemmed Molecular classification and biomarkers of clinical outcome in breast ductal carcinoma in situ: Analysis of TBCRC 038 and RAHBT cohorts
title_sort Molecular classification and biomarkers of clinical outcome in breast ductal carcinoma in situ: Analysis of TBCRC 038 and RAHBT cohorts
dc.creator.none.fl_str_mv Strand, Siri H
Rivero-Gutierrez, Belen
Houlahan, Kathleen
Seoane Fernández, Jose Antonio
King, Lorraine M.
Risom, Tyler
author Strand, Siri H
author_facet Strand, Siri H
Rivero-Gutierrez, Belen
Houlahan, Kathleen
Seoane Fernández, Jose Antonio
King, Lorraine M.
Risom, Tyler
author_role author
author2 Rivero-Gutierrez, Belen
Houlahan, Kathleen
Seoane Fernández, Jose Antonio
King, Lorraine M.
Risom, Tyler
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Strand SH] Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA. Department of Molecular Medicine, Aarhus University Hospital, 8200 Aarhus N, Denmark. [Rivero-Gutiérrez B, Risom T] Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA. [Houlahan KE] Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA. [Seoane JA] Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA. Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain. [King LM] Department of Surgery, Duke University School of Medicine, Durham, NC 27708, USA
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Marcadors tumorals
Mama - Càncer - Aspectes genètics
DISEASES::Neoplasms::Neoplasms by Site::Breast Neoplasms
Other subheadings::Other subheadings::Other subheadings::/genetics
CHEMICALS AND DRUGS::Biological Factors::Biomarkers::Biomarkers, Tumor
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de la mama
Otros calificadores::Otros calificadores::Otros calificadores::/genética
COMPUESTOS QUÍMICOS Y DROGAS::factores biológicos::biomarcadores::marcadores tumorales
topic Marcadors tumorals
Mama - Càncer - Aspectes genètics
DISEASES::Neoplasms::Neoplasms by Site::Breast Neoplasms
Other subheadings::Other subheadings::Other subheadings::/genetics
CHEMICALS AND DRUGS::Biological Factors::Biomarkers::Biomarkers, Tumor
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de la mama
Otros calificadores::Otros calificadores::Otros calificadores::/genética
COMPUESTOS QUÍMICOS Y DROGAS::factores biológicos::biomarcadores::marcadores tumorales
description Ductal carcinoma in situ; Tumor microenvironment; Whole genome sequencing
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/8732
http://hdl.handle.net/11351/8732
url https://hdl.handle.net/11351/8732
http://hdl.handle.net/11351/8732
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Cancer Cell;40(12)
https://doi.org/10.1016/j.ccell.2022.10.021
info:eu-repo/grantAgreement/ES/PE2017-2020/RYC2019-026576-I
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Scientia
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869422625104592896
spelling Molecular classification and biomarkers of clinical outcome in breast ductal carcinoma in situ: Analysis of TBCRC 038 and RAHBT cohortsStrand, Siri HRivero-Gutierrez, BelenHoulahan, KathleenSeoane Fernández, Jose AntonioKing, Lorraine M.Risom, TylerMarcadors tumoralsMama - Càncer - Aspectes genèticsDISEASES::Neoplasms::Neoplasms by Site::Breast NeoplasmsOther subheadings::Other subheadings::Other subheadings::/geneticsCHEMICALS AND DRUGS::Biological Factors::Biomarkers::Biomarkers, TumorENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de la mamaOtros calificadores::Otros calificadores::Otros calificadores::/genéticaCOMPUESTOS QUÍMICOS Y DROGAS::factores biológicos::biomarcadores::marcadores tumoralesDuctal carcinoma in situ; Tumor microenvironment; Whole genome sequencingCarcinoma ductal in situ; Microambiente tumoral; Secuenciación del genoma completoCarcinoma ductal in situ; Microambient tumoral; Seqüenciació del genoma completDuctal carcinoma in situ (DCIS) is the most common precursor of invasive breast cancer (IBC), with variable propensity for progression. We perform multiscale, integrated molecular profiling of DCIS with clinical outcomes by analyzing 774 DCIS samples from 542 patients with 7.3 years median follow-up from the Translational Breast Cancer Research Consortium 038 study and the Resource of Archival Breast Tissue cohorts. We identify 812 genes associated with ipsilateral recurrence within 5 years from treatment and develop a classifier that predicts DCIS or IBC recurrence in both cohorts. Pathways associated with recurrence include proliferation, immune response, and metabolism. Distinct stromal expression patterns and immune cell compositions are identified. Our multiscale approach employed in situ methods to generate a spatially resolved atlas of breast precancers, where complementary modalities can be directly compared and correlated with conventional pathology findings, disease states, and clinical outcome.This publication is part of the HTAN (Human Tumor Atlas Network) Consortium paper package. A list of HTAN members is available at humantumoratlas.org/htan-authors/. R01 CA185138-01 (E.S.H.); U2C CA-17-035 Pre-Cancer Atlas (PCA) Research Centers (E.S.H., R.B.W., C.M., K.P., G.A.C., K.O.); UO1 CA214183 (J.R.M.); DOD BC132057 (E.S.H., C.M.); BCRF 19-074 (E.S.H.); BCRF 19-028 (G.A.C.); PRECISION CRUK Grand Challenge (E.S.H.); R01CA193694 (R.B.W., G.A.C.), BCRF PPI-18-006 (R.B.W.). AEI RYC2019- 026576-I, "LaCaixa" Foundation LCF/PR/PR17/51120011 (J.A.S.). S.H.S. was supported by the Lundbeck Foundation (R288-2018-35) and the Danish Cancer Society (R229-A13616). K.E.H. was supported by a CIHR Banting Postdoctoral Fellowship. TBCRC 038 was conducted by the TBCRC, which receives major funding support from The Breast Cancer Research Foundation and Susan G. Komen. Some results in this paper are based upon data generated by the TCGA Research Network.ElsevierInstitut Català de la Salut[Strand SH] Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA. Department of Molecular Medicine, Aarhus University Hospital, 8200 Aarhus N, Denmark. [Rivero-Gutiérrez B, Risom T] Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA. [Houlahan KE] Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA. [Seoane JA] Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305, USA. Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain. [King LM] Department of Surgery, Duke University School of Medicine, Durham, NC 27708, USAVall d'Hebron Barcelona Hospital Campus202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/8732http://hdl.handle.net/11351/8732Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésCancer Cell;40(12)https://doi.org/10.1016/j.ccell.2022.10.021info:eu-repo/grantAgreement/ES/PE2017-2020/RYC2019-026576-IAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/87322026-05-29T05:05:01Z
score 15,811543

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