New insights Into the role of Qa-2 and HLA-G non-classical MHC-I complexes in malignancy

It is well established that the immune system can identify and destroy neoplastic transformed cells in a process known as immunosurveillance. Most studies have focused on the classical major histocompatibility complex (MHC) class Ia molecules, which are known to play an important role on the present...

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Autores: Silva, Istéfani L. da, Montero, Lucía, Ferreira, Enio, Quintanilla, Miguel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/188325
Acceso en línea:http://hdl.handle.net/10261/188325
Access Level:acceso abierto
Palabra clave:HLA-G
MHC-I
Qa-2
Cancer
Immunosurveillance
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spelling New insights Into the role of Qa-2 and HLA-G non-classical MHC-I complexes in malignancySilva, Istéfani L. daMontero, LucíaFerreira, EnioQuintanilla, MiguelHLA-GMHC-IQa-2CancerImmunosurveillanceIt is well established that the immune system can identify and destroy neoplastic transformed cells in a process known as immunosurveillance. Most studies have focused on the classical major histocompatibility complex (MHC) class Ia molecules, which are known to play an important role on the presentation of tumor antigens to the immune system in order to activate a response against tumor cells. However, a larger family of non-classical MHC class Ib-related molecules has received less attention. In this mini-review, we discuss the role of class Ib murine Qa-2 and its proposed human HLA-G homolog on immunosurveillance during embryogenesis and cancer. Whereas, both HLA-G and Qa-2 are involved in immune tolerance in pregnancy, the current evidence suggests that they play opposite roles in cancer. HLA-G appears to promote tumor progression while Qa-2 acts as a tumor suppressor awaking the immune system to reject tumor cells, as suggested by studies on different cancer cell models, such as melanoma, lymphoma, lung carcinoma, and our own results in mammary carcinoma.The research developed in our laboratories is supported by grants SAF2017-84183-R from the Spanish Ministry of Science, Innovation and Universities to MQ, and APQ-04269-10 and RED-00011-14 from the Foundation for Research Support of the State of Minas Gerais (FAPEMIG) to EF.Peer reviewedFrontiers MediaAgencia Estatal de Investigación (España)Ministerio de Ciencia, Innovación y Universidades (España)Fundação de Amparo à Pesquisa do Estado de São Paulo Minas GeraisConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201920192018info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/188325reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/SAF2017-84183-RSAF2017-84183-R/AEI/10.13039/501100011033https://doi.org/10.3389/fimmu.2018.02894Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1883252026-05-22T06:33:51Z
dc.title.none.fl_str_mv New insights Into the role of Qa-2 and HLA-G non-classical MHC-I complexes in malignancy
title New insights Into the role of Qa-2 and HLA-G non-classical MHC-I complexes in malignancy
spellingShingle New insights Into the role of Qa-2 and HLA-G non-classical MHC-I complexes in malignancy
Silva, Istéfani L. da
HLA-G
MHC-I
Qa-2
Cancer
Immunosurveillance
title_short New insights Into the role of Qa-2 and HLA-G non-classical MHC-I complexes in malignancy
title_full New insights Into the role of Qa-2 and HLA-G non-classical MHC-I complexes in malignancy
title_fullStr New insights Into the role of Qa-2 and HLA-G non-classical MHC-I complexes in malignancy
title_full_unstemmed New insights Into the role of Qa-2 and HLA-G non-classical MHC-I complexes in malignancy
title_sort New insights Into the role of Qa-2 and HLA-G non-classical MHC-I complexes in malignancy
dc.creator.none.fl_str_mv Silva, Istéfani L. da
Montero, Lucía
Ferreira, Enio
Quintanilla, Miguel
author Silva, Istéfani L. da
author_facet Silva, Istéfani L. da
Montero, Lucía
Ferreira, Enio
Quintanilla, Miguel
author_role author
author2 Montero, Lucía
Ferreira, Enio
Quintanilla, Miguel
author2_role author
author
author
dc.contributor.none.fl_str_mv Agencia Estatal de Investigación (España)
Ministerio de Ciencia, Innovación y Universidades (España)
Fundação de Amparo à Pesquisa do Estado de São Paulo Minas Gerais
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv HLA-G
MHC-I
Qa-2
Cancer
Immunosurveillance
topic HLA-G
MHC-I
Qa-2
Cancer
Immunosurveillance
description It is well established that the immune system can identify and destroy neoplastic transformed cells in a process known as immunosurveillance. Most studies have focused on the classical major histocompatibility complex (MHC) class Ia molecules, which are known to play an important role on the presentation of tumor antigens to the immune system in order to activate a response against tumor cells. However, a larger family of non-classical MHC class Ib-related molecules has received less attention. In this mini-review, we discuss the role of class Ib murine Qa-2 and its proposed human HLA-G homolog on immunosurveillance during embryogenesis and cancer. Whereas, both HLA-G and Qa-2 are involved in immune tolerance in pregnancy, the current evidence suggests that they play opposite roles in cancer. HLA-G appears to promote tumor progression while Qa-2 acts as a tumor suppressor awaking the immune system to reject tumor cells, as suggested by studies on different cancer cell models, such as melanoma, lymphoma, lung carcinoma, and our own results in mammary carcinoma.
publishDate 2018
dc.date.none.fl_str_mv 2018
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/188325
url http://hdl.handle.net/10261/188325
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/SAF2017-84183-R
SAF2017-84183-R/AEI/10.13039/501100011033
https://doi.org/10.3389/fimmu.2018.02894
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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