Pseudomonas aeruginosa Bloodstream Infections Presenting with Septic Shock in Neutropenic Cancer Patients: Impact of Empirical Antibiotic Therapy
This large, multicenter, retrospective cohort study including onco-hematological neutropenic patients with Pseudomonas aeruginosa bloodstream infection (PABSI) found that among 1213 episodes, 411 (33%) presented with septic shock. The presence of solid tumors (33.3% vs. 20.2%, p < 0.001), a high-...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/214364 |
| Acceso en línea: | https://hdl.handle.net/2445/214364 |
| Access Level: | acceso abierto |
| Palabra clave: | Xoc sèptic Càncer Septic shock Cancer |
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Pseudomonas aeruginosa Bloodstream Infections Presenting with Septic Shock in Neutropenic Cancer Patients: Impact of Empirical Antibiotic TherapyRoyo-Cebrecos, CristinaLaporte Amargós, JúliaPeña, MartaRuiz, Isabel (Ruiz Camps)García Vidal, CarolinaAbdala, EdsonOltolini, ChiaraAkova, MuratMontejo, MiguelMikulska, MalgorzataMartín Dávila, PilarHerrera, FabiánGasch, OriolDrgona, LubosPaz Morales, Hugo ManuelBrunel, Anne SophieGarcía, EstefaníaIsler, BurcuKern, Winfried V.Palacios Baena, Zaira R.Maestro de la Calle, GuillermoMontero, Maria MilagroKanj, Souha S.Sipahi, Oguz R.Calik, SebnemMárquez Gómez, IgnacioMarín, Jorge I.Gomes, Marisa Z. R.Hemmatii, PhilippAraos, RafaelPeghin, MaddalenaPozo, José Luis delYáñez, LucreciaTilley, RobertManzur, AdrianaNovo, AndrésCarratalà, JordiGudiol González, CarlotaXoc sèpticCàncerSeptic shockCancerThis large, multicenter, retrospective cohort study including onco-hematological neutropenic patients with Pseudomonas aeruginosa bloodstream infection (PABSI) found that among 1213 episodes, 411 (33%) presented with septic shock. The presence of solid tumors (33.3% vs. 20.2%, p < 0.001), a high-risk Multinational Association for Supportive Care in Cancer (MASCC) index score (92.6% vs. 57.4%; p < 0.001), pneumonia (38% vs. 19.2% p < 0.001), and infection due to multidrug-resistant P. aeruginosa (MDRPA) (33.8% vs. 21.1%, p < 0.001) were statistically significantly higher in patients with septic shock compared to those without. Patients with septic shock were more likely to receive inadequate empirical antibiotic therapy (IEAT) (21.7% vs. 16.2%, p = 0.020) and to present poorer outcomes, including a need for ICU admission (74% vs. 10.5%; p < 0.001), mechanical ventilation (49.1% vs. 5.6%; p < 0.001), and higher 7-day and 30-day case fatality rates (58.2% vs. 12%, p < 0.001, and 74% vs. 23.1%, p < 0.001, respectively). Risk factors for 30-day case fatality rate in patients with septic shock were orotracheal intubation, IEAT, infection due to MDRPA, and persistent PABSI. Therapy with granulocyte colony-stimulating factor and BSI from the urinary tract were associated with improved survival. Carbapenems were the most frequent IEAT in patients with septic shock, and the use of empirical combination therapy showed a tendency towards improved survival. Our findings emphasize the need for tailored management strategies in this high-risk population.MDPI AG2024202420242024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion13 p.application/pdfhttps://hdl.handle.net/2445/214364Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/microorganisms12040705Microorganisms, 2024, vol. 12, num. 4https://doi.org/10.3390/microorganisms12040705cc by (c) Royo Cebrecos, Cristina et al, 2024http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2143642026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Pseudomonas aeruginosa Bloodstream Infections Presenting with Septic Shock in Neutropenic Cancer Patients: Impact of Empirical Antibiotic Therapy |
| title |
Pseudomonas aeruginosa Bloodstream Infections Presenting with Septic Shock in Neutropenic Cancer Patients: Impact of Empirical Antibiotic Therapy |
| spellingShingle |
Pseudomonas aeruginosa Bloodstream Infections Presenting with Septic Shock in Neutropenic Cancer Patients: Impact of Empirical Antibiotic Therapy Royo-Cebrecos, Cristina Xoc sèptic Càncer Septic shock Cancer |
| title_short |
Pseudomonas aeruginosa Bloodstream Infections Presenting with Septic Shock in Neutropenic Cancer Patients: Impact of Empirical Antibiotic Therapy |
| title_full |
Pseudomonas aeruginosa Bloodstream Infections Presenting with Septic Shock in Neutropenic Cancer Patients: Impact of Empirical Antibiotic Therapy |
| title_fullStr |
Pseudomonas aeruginosa Bloodstream Infections Presenting with Septic Shock in Neutropenic Cancer Patients: Impact of Empirical Antibiotic Therapy |
| title_full_unstemmed |
Pseudomonas aeruginosa Bloodstream Infections Presenting with Septic Shock in Neutropenic Cancer Patients: Impact of Empirical Antibiotic Therapy |
| title_sort |
Pseudomonas aeruginosa Bloodstream Infections Presenting with Septic Shock in Neutropenic Cancer Patients: Impact of Empirical Antibiotic Therapy |
| dc.creator.none.fl_str_mv |
Royo-Cebrecos, Cristina Laporte Amargós, Júlia Peña, Marta Ruiz, Isabel (Ruiz Camps) García Vidal, Carolina Abdala, Edson Oltolini, Chiara Akova, Murat Montejo, Miguel Mikulska, Malgorzata Martín Dávila, Pilar Herrera, Fabián Gasch, Oriol Drgona, Lubos Paz Morales, Hugo Manuel Brunel, Anne Sophie García, Estefanía Isler, Burcu Kern, Winfried V. Palacios Baena, Zaira R. Maestro de la Calle, Guillermo Montero, Maria Milagro Kanj, Souha S. Sipahi, Oguz R. Calik, Sebnem Márquez Gómez, Ignacio Marín, Jorge I. Gomes, Marisa Z. R. Hemmatii, Philipp Araos, Rafael Peghin, Maddalena Pozo, José Luis del Yáñez, Lucrecia Tilley, Robert Manzur, Adriana Novo, Andrés Carratalà, Jordi Gudiol González, Carlota |
| author |
Royo-Cebrecos, Cristina |
| author_facet |
Royo-Cebrecos, Cristina Laporte Amargós, Júlia Peña, Marta Ruiz, Isabel (Ruiz Camps) García Vidal, Carolina Abdala, Edson Oltolini, Chiara Akova, Murat Montejo, Miguel Mikulska, Malgorzata Martín Dávila, Pilar Herrera, Fabián Gasch, Oriol Drgona, Lubos Paz Morales, Hugo Manuel Brunel, Anne Sophie García, Estefanía Isler, Burcu Kern, Winfried V. Palacios Baena, Zaira R. Maestro de la Calle, Guillermo Montero, Maria Milagro Kanj, Souha S. Sipahi, Oguz R. Calik, Sebnem Márquez Gómez, Ignacio Marín, Jorge I. Gomes, Marisa Z. R. Hemmatii, Philipp Araos, Rafael Peghin, Maddalena Pozo, José Luis del Yáñez, Lucrecia Tilley, Robert Manzur, Adriana Novo, Andrés Carratalà, Jordi Gudiol González, Carlota |
| author_role |
author |
| author2 |
Laporte Amargós, Júlia Peña, Marta Ruiz, Isabel (Ruiz Camps) García Vidal, Carolina Abdala, Edson Oltolini, Chiara Akova, Murat Montejo, Miguel Mikulska, Malgorzata Martín Dávila, Pilar Herrera, Fabián Gasch, Oriol Drgona, Lubos Paz Morales, Hugo Manuel Brunel, Anne Sophie García, Estefanía Isler, Burcu Kern, Winfried V. Palacios Baena, Zaira R. Maestro de la Calle, Guillermo Montero, Maria Milagro Kanj, Souha S. Sipahi, Oguz R. Calik, Sebnem Márquez Gómez, Ignacio Marín, Jorge I. Gomes, Marisa Z. R. Hemmatii, Philipp Araos, Rafael Peghin, Maddalena Pozo, José Luis del Yáñez, Lucrecia Tilley, Robert Manzur, Adriana Novo, Andrés Carratalà, Jordi Gudiol González, Carlota |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Xoc sèptic Càncer Septic shock Cancer |
| topic |
Xoc sèptic Càncer Septic shock Cancer |
| description |
This large, multicenter, retrospective cohort study including onco-hematological neutropenic patients with Pseudomonas aeruginosa bloodstream infection (PABSI) found that among 1213 episodes, 411 (33%) presented with septic shock. The presence of solid tumors (33.3% vs. 20.2%, p < 0.001), a high-risk Multinational Association for Supportive Care in Cancer (MASCC) index score (92.6% vs. 57.4%; p < 0.001), pneumonia (38% vs. 19.2% p < 0.001), and infection due to multidrug-resistant P. aeruginosa (MDRPA) (33.8% vs. 21.1%, p < 0.001) were statistically significantly higher in patients with septic shock compared to those without. Patients with septic shock were more likely to receive inadequate empirical antibiotic therapy (IEAT) (21.7% vs. 16.2%, p = 0.020) and to present poorer outcomes, including a need for ICU admission (74% vs. 10.5%; p < 0.001), mechanical ventilation (49.1% vs. 5.6%; p < 0.001), and higher 7-day and 30-day case fatality rates (58.2% vs. 12%, p < 0.001, and 74% vs. 23.1%, p < 0.001, respectively). Risk factors for 30-day case fatality rate in patients with septic shock were orotracheal intubation, IEAT, infection due to MDRPA, and persistent PABSI. Therapy with granulocyte colony-stimulating factor and BSI from the urinary tract were associated with improved survival. Carbapenems were the most frequent IEAT in patients with septic shock, and the use of empirical combination therapy showed a tendency towards improved survival. Our findings emphasize the need for tailored management strategies in this high-risk population. |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2024 2024 2024 2024 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/214364 |
| url |
https://hdl.handle.net/2445/214364 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Reproducció del document publicat a: https://doi.org/10.3390/microorganisms12040705 Microorganisms, 2024, vol. 12, num. 4 https://doi.org/10.3390/microorganisms12040705 |
| dc.rights.none.fl_str_mv |
cc by (c) Royo Cebrecos, Cristina et al, 2024 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess |
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cc by (c) Royo Cebrecos, Cristina et al, 2024 http://creativecommons.org/licenses/by/3.0/es/ |
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openAccess |
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13 p. application/pdf |
| dc.publisher.none.fl_str_mv |
MDPI AG |
| publisher.none.fl_str_mv |
MDPI AG |
| dc.source.none.fl_str_mv |
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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