Multilevel regulation of peroxisomal proteome by posttranslational modifications

Peroxisomes, which are ubiquitous organelles in all eukaryotes, are highly dynamic organelles that are essential for development and stress responses. Plant peroxisomes are involved in major metabolic pathways, such as fatty acid β-oxidation, photorespiration, ureide and polyamine metabolism, in the...

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Autores: Sandalio, Luisa M., Gotor, Cecilia, Romero, Luis C., Romero-Puertas, María C.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/197787
Acceso en línea:http://hdl.handle.net/10261/197787
Access Level:acceso abierto
Palabra clave:Persulfidation
Posttranslational modifications
Phosphorylation
Reactive oxygen species
Sulfenylation
Nitric oxide
S-nitrosylation
Nitration
Peroxisome
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spelling Multilevel regulation of peroxisomal proteome by posttranslational modificationsSandalio, Luisa M.Gotor, CeciliaRomero, Luis C.Romero-Puertas, María C.PersulfidationPosttranslational modificationsPhosphorylationReactive oxygen speciesSulfenylationNitric oxideS-nitrosylationNitrationPeroxisomePeroxisomes, which are ubiquitous organelles in all eukaryotes, are highly dynamic organelles that are essential for development and stress responses. Plant peroxisomes are involved in major metabolic pathways, such as fatty acid β-oxidation, photorespiration, ureide and polyamine metabolism, in the biosynthesis of jasmonic, indolacetic, and salicylic acid hormones, as well as in signaling molecules such as reactive oxygen and nitrogen species (ROS/RNS). Peroxisomes are involved in the perception of environmental changes, which is a complex process involving the regulation of gene expression and protein functionality by protein post-translational modifications (PTMs). Although there has been a growing interest in individual PTMs in peroxisomes over the last ten years, their role and cross-talk in the whole peroxisomal proteome remain unclear. This review provides up-to-date information on the function and crosstalk of the main peroxisomal PTMs. Analysis of whole peroxisomal proteomes shows that a very large number of peroxisomal proteins are targeted by multiple PTMs, which affect redox balance, photorespiration, the glyoxylate cycle, and lipid metabolism. This multilevel PTM regulation could boost the plasticity of peroxisomes and their capacity to regulate metabolism in response to environmental changes.This study was co-funded by ERDF (UE) and the Spanish Ministry of Science, Innovation and Universities grants PGC2018-098372-B-I00 and BIO2016-76633-P.Peer ReviewedAgencia Estatal de Investigación (España)Ministerio de Ciencia, Innovación y Universidades (España)European CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2020202020192020info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/197787reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BIO2016-76633-PPGC2018-098372-B-100/AEI/10.13039/501100011033info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PGC2018-098372-B-100https://www.mdpi.com/1422-0067/20/19/4881Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1977872026-05-22T06:33:51Z
dc.title.none.fl_str_mv Multilevel regulation of peroxisomal proteome by posttranslational modifications
title Multilevel regulation of peroxisomal proteome by posttranslational modifications
spellingShingle Multilevel regulation of peroxisomal proteome by posttranslational modifications
Sandalio, Luisa M.
Persulfidation
Posttranslational modifications
Phosphorylation
Reactive oxygen species
Sulfenylation
Nitric oxide
S-nitrosylation
Nitration
Peroxisome
title_short Multilevel regulation of peroxisomal proteome by posttranslational modifications
title_full Multilevel regulation of peroxisomal proteome by posttranslational modifications
title_fullStr Multilevel regulation of peroxisomal proteome by posttranslational modifications
title_full_unstemmed Multilevel regulation of peroxisomal proteome by posttranslational modifications
title_sort Multilevel regulation of peroxisomal proteome by posttranslational modifications
dc.creator.none.fl_str_mv Sandalio, Luisa M.
Gotor, Cecilia
Romero, Luis C.
Romero-Puertas, María C.
author Sandalio, Luisa M.
author_facet Sandalio, Luisa M.
Gotor, Cecilia
Romero, Luis C.
Romero-Puertas, María C.
author_role author
author2 Gotor, Cecilia
Romero, Luis C.
Romero-Puertas, María C.
author2_role author
author
author
dc.contributor.none.fl_str_mv Agencia Estatal de Investigación (España)
Ministerio de Ciencia, Innovación y Universidades (España)
European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Persulfidation
Posttranslational modifications
Phosphorylation
Reactive oxygen species
Sulfenylation
Nitric oxide
S-nitrosylation
Nitration
Peroxisome
topic Persulfidation
Posttranslational modifications
Phosphorylation
Reactive oxygen species
Sulfenylation
Nitric oxide
S-nitrosylation
Nitration
Peroxisome
description Peroxisomes, which are ubiquitous organelles in all eukaryotes, are highly dynamic organelles that are essential for development and stress responses. Plant peroxisomes are involved in major metabolic pathways, such as fatty acid β-oxidation, photorespiration, ureide and polyamine metabolism, in the biosynthesis of jasmonic, indolacetic, and salicylic acid hormones, as well as in signaling molecules such as reactive oxygen and nitrogen species (ROS/RNS). Peroxisomes are involved in the perception of environmental changes, which is a complex process involving the regulation of gene expression and protein functionality by protein post-translational modifications (PTMs). Although there has been a growing interest in individual PTMs in peroxisomes over the last ten years, their role and cross-talk in the whole peroxisomal proteome remain unclear. This review provides up-to-date information on the function and crosstalk of the main peroxisomal PTMs. Analysis of whole peroxisomal proteomes shows that a very large number of peroxisomal proteins are targeted by multiple PTMs, which affect redox balance, photorespiration, the glyoxylate cycle, and lipid metabolism. This multilevel PTM regulation could boost the plasticity of peroxisomes and their capacity to regulate metabolism in response to environmental changes.
publishDate 2019
dc.date.none.fl_str_mv 2019
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/197787
url http://hdl.handle.net/10261/197787
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BIO2016-76633-P
PGC2018-098372-B-100/AEI/10.13039/501100011033
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PGC2018-098372-B-100
https://www.mdpi.com/1422-0067/20/19/4881
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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