Spontaneous brain activity: how dynamics and topology shape the emergent correlation structure
Neuroscienti c research in the last decades has revealed that ongoing brain activity exhibits highly structured spatio-temporal patterns of neural activations. The fundamental core of this endogenously generated correlation structure re ects, to a large extent, the complex anatomical organization of...
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| Tipo de recurso: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2016 |
| País: | España |
| Institución: | CBUC, CESCA |
| Repositorio: | TDR. Tesis Doctorales en Red |
| OAI Identifier: | oai:www.tdx.cat:10803/395172 |
| Acceso en línea: | http://hdl.handle.net/10803/395172 |
| Access Level: | acceso abierto |
| Palabra clave: | Investigación neurocientífica Neuroscientic research Cerebro Brain 62 |
| Sumario: | Neuroscienti c research in the last decades has revealed that ongoing brain activity exhibits highly structured spatio-temporal patterns of neural activations. The fundamental core of this endogenously generated correlation structure re ects, to a large extent, the complex anatomical organization of the central nervous system, whereas the variability of spontaneous brain activity is determined by regional properties. These cellular and circuit properties are in turn modulated either by external stimuli and ongoing computations as well as by signi cant changes in local dynamics due to the internal system's physiology, such as sleep, or induced by external factors, such as injuries, diseases, hypnosis or psychoactive substances. In this dissertation we will demonstrate how manipulations of regional dynamics and of the topological structure de ned by anatomy determine changes in the emergent large-scale correlation structure displayed by spontaneous brain activity, and how this can be used to shed light on the intriguing but still elusive relationship between structure and function. |
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