Entrapment of Citrus limon var. pompia Essential Oil or Pure Citral in Liposomes Tailored as Mouthwash for the Treatment of Oral Cavity Diseases

This work aimed at developing a mouthwash based on liposomes loading Citrus limon var. pompia essential oil or citral to treat oropharyngeal diseases. Vesicles were prepared by dispersing phosphatidylcholine and pompia essential oil or citral at increasing amounts (12, 25 and 50 mg/mL) in water. Tra...

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Autores: Palmas, Lucia, Aroffu, Matteo, Petretto, Giacomo L., Escribano Ferrer, Elvira, Díez Sales, Octavio, Usach, Iris, Peris, José Esteban, Marongiu, Francesca, Ghavam, Mansureh, Fais, Sara, Orrù, Germano, Rached, Rita Abi, Manca, Maria Letizia, Manconi, Maria
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/176075
Acceso en línea:https://hdl.handle.net/2445/176075
Access Level:acceso abierto
Palabra clave:Olis essencials
Llimones
Malalties de la boca
Estreptococs
Essences and essential oils
Lemons
Mouth diseases
Streptococcus
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spelling Entrapment of Citrus limon var. pompia Essential Oil or Pure Citral in Liposomes Tailored as Mouthwash for the Treatment of Oral Cavity DiseasesPalmas, LuciaAroffu, MatteoPetretto, Giacomo L.Escribano Ferrer, ElviraDíez Sales, OctavioUsach, IrisPeris, José EstebanMarongiu, FrancescaGhavam, MansurehFais, SaraOrrù, GermanoRached, Rita AbiManca, Maria LetiziaManconi, MariaOlis essencialsLlimonesMalalties de la bocaEstreptococsEssences and essential oilsLemonsMouth diseasesStreptococcusThis work aimed at developing a mouthwash based on liposomes loading Citrus limon var. pompia essential oil or citral to treat oropharyngeal diseases. Vesicles were prepared by dispersing phosphatidylcholine and pompia essential oil or citral at increasing amounts (12, 25 and 50 mg/mL) in water. Transparent vesicle dispersions were obtained by direct sonication avoiding the use of organic solvents. Cryogenic transmission electron microscopy (cryo-TEM) confirmed the formation of unilamellar, spherical and regularly shaped vesicles. Essential oil and citral loaded liposomes were small in size (~110 and ~100 nm, respectively) and negatively charged. Liposomes, especially those loading citral, were highly stable as their physico-chemical properties did not change during storage. The formulations were highly biocompatible against keratinocytes, were able to counteract the damages induced in cells by using hydrogen peroxide, and able to increase the rate of skin repair. In addition, liposomes loading citral at higher concentrations inhibited the proliferation of cariogenic bacteriumMDPI2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/176075Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/ph13090216Pharmaceuticals, 2020, vol. 13, num. 9, p. 216https://doi.org/10.3390/ph13090216cc-by (c) Palmas, Lucia et al., 2020http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1760752026-05-27T06:46:51Z
dc.title.none.fl_str_mv Entrapment of Citrus limon var. pompia Essential Oil or Pure Citral in Liposomes Tailored as Mouthwash for the Treatment of Oral Cavity Diseases
title Entrapment of Citrus limon var. pompia Essential Oil or Pure Citral in Liposomes Tailored as Mouthwash for the Treatment of Oral Cavity Diseases
spellingShingle Entrapment of Citrus limon var. pompia Essential Oil or Pure Citral in Liposomes Tailored as Mouthwash for the Treatment of Oral Cavity Diseases
Palmas, Lucia
Olis essencials
Llimones
Malalties de la boca
Estreptococs
Essences and essential oils
Lemons
Mouth diseases
Streptococcus
title_short Entrapment of Citrus limon var. pompia Essential Oil or Pure Citral in Liposomes Tailored as Mouthwash for the Treatment of Oral Cavity Diseases
title_full Entrapment of Citrus limon var. pompia Essential Oil or Pure Citral in Liposomes Tailored as Mouthwash for the Treatment of Oral Cavity Diseases
title_fullStr Entrapment of Citrus limon var. pompia Essential Oil or Pure Citral in Liposomes Tailored as Mouthwash for the Treatment of Oral Cavity Diseases
title_full_unstemmed Entrapment of Citrus limon var. pompia Essential Oil or Pure Citral in Liposomes Tailored as Mouthwash for the Treatment of Oral Cavity Diseases
title_sort Entrapment of Citrus limon var. pompia Essential Oil or Pure Citral in Liposomes Tailored as Mouthwash for the Treatment of Oral Cavity Diseases
dc.creator.none.fl_str_mv Palmas, Lucia
Aroffu, Matteo
Petretto, Giacomo L.
Escribano Ferrer, Elvira
Díez Sales, Octavio
Usach, Iris
Peris, José Esteban
Marongiu, Francesca
Ghavam, Mansureh
Fais, Sara
Orrù, Germano
Rached, Rita Abi
Manca, Maria Letizia
Manconi, Maria
author Palmas, Lucia
author_facet Palmas, Lucia
Aroffu, Matteo
Petretto, Giacomo L.
Escribano Ferrer, Elvira
Díez Sales, Octavio
Usach, Iris
Peris, José Esteban
Marongiu, Francesca
Ghavam, Mansureh
Fais, Sara
Orrù, Germano
Rached, Rita Abi
Manca, Maria Letizia
Manconi, Maria
author_role author
author2 Aroffu, Matteo
Petretto, Giacomo L.
Escribano Ferrer, Elvira
Díez Sales, Octavio
Usach, Iris
Peris, José Esteban
Marongiu, Francesca
Ghavam, Mansureh
Fais, Sara
Orrù, Germano
Rached, Rita Abi
Manca, Maria Letizia
Manconi, Maria
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Olis essencials
Llimones
Malalties de la boca
Estreptococs
Essences and essential oils
Lemons
Mouth diseases
Streptococcus
topic Olis essencials
Llimones
Malalties de la boca
Estreptococs
Essences and essential oils
Lemons
Mouth diseases
Streptococcus
description This work aimed at developing a mouthwash based on liposomes loading Citrus limon var. pompia essential oil or citral to treat oropharyngeal diseases. Vesicles were prepared by dispersing phosphatidylcholine and pompia essential oil or citral at increasing amounts (12, 25 and 50 mg/mL) in water. Transparent vesicle dispersions were obtained by direct sonication avoiding the use of organic solvents. Cryogenic transmission electron microscopy (cryo-TEM) confirmed the formation of unilamellar, spherical and regularly shaped vesicles. Essential oil and citral loaded liposomes were small in size (~110 and ~100 nm, respectively) and negatively charged. Liposomes, especially those loading citral, were highly stable as their physico-chemical properties did not change during storage. The formulations were highly biocompatible against keratinocytes, were able to counteract the damages induced in cells by using hydrogen peroxide, and able to increase the rate of skin repair. In addition, liposomes loading citral at higher concentrations inhibited the proliferation of cariogenic bacterium
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/176075
url https://hdl.handle.net/2445/176075
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/ph13090216
Pharmaceuticals, 2020, vol. 13, num. 9, p. 216
https://doi.org/10.3390/ph13090216
dc.rights.none.fl_str_mv cc-by (c) Palmas, Lucia et al., 2020
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Palmas, Lucia et al., 2020
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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