Alzheimer's disease and vascular biology - A focus on the procoagulant state

Alzheimer's disease (AD) is characterized by a multifactorial pathophysiology. Beyond its classical hallmarks, growing evidence highlights vascular contributions, including hemostatic dysregulation and a prothrombotic state in AD. This review focuses on recent findings concerning two key blood...

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Detalles Bibliográficos
Autores: Casquero-Veiga, Marta, Ceron, Carlos, Cortés-Canteli, Marta
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
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Acceso en línea:http://hdl.handle.net/10261/431030
https://api.elsevier.com/content/abstract/scopus_id/105004547567
Access Level:acceso abierto
Palabra clave:Ensure healthy lives and promote well-being for all at all ages
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spelling Alzheimer's disease and vascular biology - A focus on the procoagulant stateCasquero-Veiga, MartaCeron, CarlosCortés-Canteli, MartaEnsure healthy lives and promote well-being for all at all agesAlzheimer's disease (AD) is characterized by a multifactorial pathophysiology. Beyond its classical hallmarks, growing evidence highlights vascular contributions, including hemostatic dysregulation and a prothrombotic state in AD. This review focuses on recent findings concerning two key blood clot components-fibrin(ogen) and platelets-and their roles in AD pathology, including fibrinogen's abnormal accumulation in the AD brain, its interaction with amyloid-β, together with the associated impacts on clot stability, vascular occlusion, and neuroinflammation; and the potential switch of platelets along the AD continuum from protective to deleterious. This review provides an update on the interplay between vascular dysfunction and AD, underscoring the need for comprehensive integrative research to address AD's complexity and advocating for personalized approaches to tackle this multifaceted disorder.This work was funded by grant JPND2020-568-025, an EU Joint Programme-Neurodegenerative Disease Research (JPND) project supported through the Spanish National Institute of Health Carlos III (ISCIII) under the aegis of JPND (project AC20/00077, co-funded by the European Regional Development Fund “A way to make Europe”); and by grant CNS2023-144316 funded by the MCIN/AEI/10.13039/501100011033 and by the EU NextGenerationEU/PRTR. CNIC is a Severo Ochoa Center of Excellence (CEX2020-001041-S) and is supported by the ISCIII, the Spanish Ministry for Science and Innovation, and Pro-CNIC Foundation. MCV is supported by a BrightFocus Foundation Postdoctoral Fellowship in Alzheimer's Disease Research (A2023012F), and grant JDC2022-048922-I funded by MCIN/AEI/10.13039/501100011033 and the EU NextGenerationEU/PRTR. Figure was partially created with Servier Medical Art (https://smart.servier.com/).Peer reviewedElsevierInstituto de Salud Carlos IIIEuropean CommissionMinisterio de Ciencia e Innovación (España)#NODATA##NODATA#0000-0001-8802-4338202620262025info:eu-repo/semantics/articlePublisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/431030https://api.elsevier.com/content/abstract/scopus_id/105004547567reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/EC/MCIN/AEIinfo:eu-repo/grantAgreement/EC/MCIN/AEICurrent opinion in cell biologyhttps://doi.org/10.1016/j.ceb.2025.102528Síinfo:eu-repo/semantics/openAccessoai:dnet:digitalcsic_::0745a1c71d1f45f08a6b5124a4a824582026-05-22T06:33:51Z
dc.title.none.fl_str_mv Alzheimer's disease and vascular biology - A focus on the procoagulant state
title Alzheimer's disease and vascular biology - A focus on the procoagulant state
spellingShingle Alzheimer's disease and vascular biology - A focus on the procoagulant state
Casquero-Veiga, Marta
Ensure healthy lives and promote well-being for all at all ages
title_short Alzheimer's disease and vascular biology - A focus on the procoagulant state
title_full Alzheimer's disease and vascular biology - A focus on the procoagulant state
title_fullStr Alzheimer's disease and vascular biology - A focus on the procoagulant state
title_full_unstemmed Alzheimer's disease and vascular biology - A focus on the procoagulant state
title_sort Alzheimer's disease and vascular biology - A focus on the procoagulant state
dc.creator.none.fl_str_mv Casquero-Veiga, Marta
Ceron, Carlos
Cortés-Canteli, Marta
author Casquero-Veiga, Marta
author_facet Casquero-Veiga, Marta
Ceron, Carlos
Cortés-Canteli, Marta
author_role author
author2 Ceron, Carlos
Cortés-Canteli, Marta
author2_role author
author
dc.contributor.none.fl_str_mv Instituto de Salud Carlos III
European Commission
Ministerio de Ciencia e Innovación (España)
#NODATA#
#NODATA#
0000-0001-8802-4338
dc.subject.none.fl_str_mv Ensure healthy lives and promote well-being for all at all ages
topic Ensure healthy lives and promote well-being for all at all ages
description Alzheimer's disease (AD) is characterized by a multifactorial pathophysiology. Beyond its classical hallmarks, growing evidence highlights vascular contributions, including hemostatic dysregulation and a prothrombotic state in AD. This review focuses on recent findings concerning two key blood clot components-fibrin(ogen) and platelets-and their roles in AD pathology, including fibrinogen's abnormal accumulation in the AD brain, its interaction with amyloid-β, together with the associated impacts on clot stability, vascular occlusion, and neuroinflammation; and the potential switch of platelets along the AD continuum from protective to deleterious. This review provides an update on the interplay between vascular dysfunction and AD, underscoring the need for comprehensive integrative research to address AD's complexity and advocating for personalized approaches to tackle this multifaceted disorder.
publishDate 2025
dc.date.none.fl_str_mv 2025
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
Publisher's version
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status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/431030
https://api.elsevier.com/content/abstract/scopus_id/105004547567
url http://hdl.handle.net/10261/431030
https://api.elsevier.com/content/abstract/scopus_id/105004547567
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
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info:eu-repo/grantAgreement/EC/MCIN/AEI
info:eu-repo/grantAgreement/EC/MCIN/AEI
Current opinion in cell biology
https://doi.org/10.1016/j.ceb.2025.102528
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
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