Adaptation of the Human Gut Microbiota Metabolic Network During the First Year After Birth

Predicting the metabolic behavior of the human gut microbiota in different contexts is one of the most promising areas of constraint-based modeling. Recently, we presented a supra-organismal approach to build context-specific metabolic networks of bacterial communities using functional and taxonomic...

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Detalhes bibliográficos
Autores: Fuertes A, Pérez-Burillo S, Apaolaza I, Vallès Y, Francino MP, Rufián-Henares JÁ, Planes FJ
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Recursos:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p3641
Acesso em linha:https://fisabio.portalinvestigacion.com/publicaciones/3641
Access Level:acceso abierto
Palavra-chave:personalized nutrition
metabolic networks
human gut microbiome
metagenomics
metabolomics
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spelling Adaptation of the Human Gut Microbiota Metabolic Network During the First Year After BirthFuertes APérez-Burillo SApaolaza IVallès YFrancino MPRufián-Henares JÁPlanes FJpersonalized nutritionmetabolic networkshuman gut microbiomemetagenomicsmetabolomicsPredicting the metabolic behavior of the human gut microbiota in different contexts is one of the most promising areas of constraint-based modeling. Recently, we presented a supra-organismal approach to build context-specific metabolic networks of bacterial communities using functional and taxonomic assignments of meta-omics data. In this work, this algorithm is applied to elucidate the metabolic changes induced over the first year after birth in the gut microbiota of a cohort of Spanish infants. We used metagenomics data of fecal samples and nutritional data of 13 infants at five time points. The resulting networks for each time point were analyzed, finding significant alterations once solid food is introduced in the diet. Our work shows that solid food leads to a different pattern of output metabolites that can be potentially released from the gut microbiota to the host. Experimental validation is presented for ferulate, a neuroprotective metabolite involved in the gut-brain axis.FRONTIERS MEDIA SA2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/3641Frontiers in MicrobiologyISSN: 1664302Xreponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p36412026-06-11T12:45:17Z
dc.title.none.fl_str_mv Adaptation of the Human Gut Microbiota Metabolic Network During the First Year After Birth
title Adaptation of the Human Gut Microbiota Metabolic Network During the First Year After Birth
spellingShingle Adaptation of the Human Gut Microbiota Metabolic Network During the First Year After Birth
Fuertes A
personalized nutrition
metabolic networks
human gut microbiome
metagenomics
metabolomics
title_short Adaptation of the Human Gut Microbiota Metabolic Network During the First Year After Birth
title_full Adaptation of the Human Gut Microbiota Metabolic Network During the First Year After Birth
title_fullStr Adaptation of the Human Gut Microbiota Metabolic Network During the First Year After Birth
title_full_unstemmed Adaptation of the Human Gut Microbiota Metabolic Network During the First Year After Birth
title_sort Adaptation of the Human Gut Microbiota Metabolic Network During the First Year After Birth
dc.creator.none.fl_str_mv Fuertes A
Pérez-Burillo S
Apaolaza I
Vallès Y
Francino MP
Rufián-Henares JÁ
Planes FJ
author Fuertes A
author_facet Fuertes A
Pérez-Burillo S
Apaolaza I
Vallès Y
Francino MP
Rufián-Henares JÁ
Planes FJ
author_role author
author2 Pérez-Burillo S
Apaolaza I
Vallès Y
Francino MP
Rufián-Henares JÁ
Planes FJ
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv personalized nutrition
metabolic networks
human gut microbiome
metagenomics
metabolomics
topic personalized nutrition
metabolic networks
human gut microbiome
metagenomics
metabolomics
description Predicting the metabolic behavior of the human gut microbiota in different contexts is one of the most promising areas of constraint-based modeling. Recently, we presented a supra-organismal approach to build context-specific metabolic networks of bacterial communities using functional and taxonomic assignments of meta-omics data. In this work, this algorithm is applied to elucidate the metabolic changes induced over the first year after birth in the gut microbiota of a cohort of Spanish infants. We used metagenomics data of fecal samples and nutritional data of 13 infants at five time points. The resulting networks for each time point were analyzed, finding significant alterations once solid food is introduced in the diet. Our work shows that solid food leads to a different pattern of output metabolites that can be potentially released from the gut microbiota to the host. Experimental validation is presented for ferulate, a neuroprotective metabolite involved in the gut-brain axis.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/3641
url https://fisabio.portalinvestigacion.com/publicaciones/3641
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv FRONTIERS MEDIA SA
publisher.none.fl_str_mv FRONTIERS MEDIA SA
dc.source.none.fl_str_mv Frontiers in Microbiology
ISSN: 1664302X
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869422574546452480
score 15.811543

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