Intermittent hypoxia is associated with high hypoxia inducible factor-1α but not high vascular endothelial growth factor cell expression in tumors of cutaneous melanoma patients

Epidemiological associations linking between obstructive sleep apnea and poorer solid malignant tumor outcomes have recently emerged. Putative pathways proposed to explain that these associations have included enhanced hypoxia inducible factor (HIF)-1α and vascular endothelial growth factor (VEGF) c...

Descripción completa

Detalles Bibliográficos
Autores: Almendros, Isaac|||0000-0002-1998-9379, Martínez García, Miguel Ángel|||0000-0002-7321-1891, Campos-Rodríguez, Francisco, Riveiro-Falkenbach, Erica, Rodríguez-Peralto, José L., Nagore, Eduardo|||0000-0003-3433-8707, Martorell-Calatayud, Antonio, Hernández Blasco, Luis Manuel, Bañuls Roca, Jose, Chiner, Eusebi|||0000-0003-3374-4623, Sánchez de la Torre, Alicia|||0000-0003-3446-1481, Abad Capa, Jorge|||0000-0002-8129-7859, Montserrat Canal, José Ma|||0000-0003-3098-4605, Pérez-Gil, Amalia, Cabriada-Nuño, Valentín|||0000-0003-1124-7108, Cano-Pumarega, Irene|||0000-0003-1543-7187, Corral-Peñafiel, Jaime, Diaz-Cambriles, Trinidad, Mediano, Olga|||0000-0001-7824-1523, Dalmau-Arias, Joan, Farré, Ramon|||0000-0002-9084-7824, Gozal, David|||0000-0001-8195-6036, Molina Herrera, Elidia, García Martín, Rosa M., Niveiro de Jaime, Maria, Moreno Fernández, Sara, Barbé, Ferran|||0000-0002-2340-8928, Sánchez de la Torre, Manuel|||0000-0002-5695-348X, de Eusebio, Esther, Landete, Pedro|||0000-0002-9631-9408, Gordon, Manuel Moragón, Arias, Eva, Masa, Fernando, Herrada, Carlos González, Carrera, Cristina|||0000-0003-1608-8820, Muñoz Ferrer, Aida|||0000-0001-6722-0639, Boada, Aram|||0000-0001-9809-5308, Fortuna Gutiérrez, Ana Mª|||0000-0002-3619-1609, Mayos, Merce|||0000-0003-3972-3671, García, Jesús Gardeazabal
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:286896
Acceso en línea:https://ddd.uab.cat/record/286896
https://dx.doi.org/urn:doi:10.3389/fneur.2018.00272
Access Level:acceso abierto
Palabra clave:Hypoxia-inducible factor
Intermittent hypoxia
Melanoma
Obstructive sleep apnea
Vascular endothelial growth factor
Descripción
Sumario:Epidemiological associations linking between obstructive sleep apnea and poorer solid malignant tumor outcomes have recently emerged. Putative pathways proposed to explain that these associations have included enhanced hypoxia inducible factor (HIF)-1α and vascular endothelial growth factor (VEGF) cell expression in the tumor and altered immune functions via intermittent hypoxia (IH). Here, we examined relationships between HIF-1α and VEGF expression and nocturnal IH in cutaneous melanoma (CM) tumor samples. Prospectively recruited patients with CM tumor samples were included and underwent overnight polygraphy. General clinical features, apnea-hypopnea index (AHI), desaturation index (DI4%), and CM characteristics were recorded. Histochemical assessments of VEGF and HIF-1α were performed, and the percentage of positive cells (0, < 25, 25-50, 51-75,.

Similares en LA Referencia