SoxD genes are required for adult neural stem cell activation

19 páginas, 6 figuras. Supplemental information can be found online at https://doi.org/10.1016/j. celrep.2022.110313.

Detalhes bibliográficos
Autores: Li, Lingling, Medina-Menéndez, Cristina, García-Corzo, Laura, Córdoba-Beldad, Carmen M., Quiroga, Alejandra C., Calleja Barca, Elena, Zinchuk, Valeriya, Muñoz-López, Sara, Rodríguez-Martín, Pilar, Ciorraga, Maria, Colmena, Inés, Fernández, Silvia, Vicario-Abejón, Carlos, Nicolis, Silvia K., Lefebvre, Véronique, Mira, Helena, Morales, Aixa V.
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/261855
Acesso em linha:http://hdl.handle.net/10261/261855
Access Level:acceso abierto
Palavra-chave:Lamb-Shaffer syndrome
SOXopathy
Sox5
Sox6
Tolchin-Le Caignec syndrome
Adult neurogenesis
Hippocampus
Neural stem cells
Quiescence
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repository_id_str
spelling SoxD genes are required for adult neural stem cell activationLi, LinglingMedina-Menéndez, CristinaGarcía-Corzo, LauraCórdoba-Beldad, Carmen M.Quiroga, Alejandra C.Calleja Barca, ElenaZinchuk, ValeriyaMuñoz-López, SaraRodríguez-Martín, PilarCiorraga, MariaColmena, InésFernández, SilviaVicario-Abejón, CarlosNicolis, Silvia K.Lefebvre, VéroniqueMira, HelenaMorales, Aixa V.Lamb-Shaffer syndromeSOXopathySox5Sox6Tolchin-Le Caignec syndromeAdult neurogenesisHippocampusNeural stem cellsQuiescence19 páginas, 6 figuras. Supplemental information can be found online at https://doi.org/10.1016/j. celrep.2022.110313.The adult neurogenic niche in the hippocampus is maintained through activation of reversibly quiescent neural stem cells (NSCs) with radial glia-like morphology (RGLs). Here, we show that the expression of SoxD transcription factors Sox5 and Sox6 is enriched in activated RGLs. Using inducible deletion of Sox5 or Sox6 in the adult mouse brain, we show that both genes are required for RGL activation and the generation of new neurons. Conversely, Sox5 overexpression in cultured NSCs interferes with entry in quiescence. Mechanistically, expression of the proneural protein Ascl1 (a key RGL regulator) is severely downregulated in SoxD-deficient RGLs, and Ascl1 transcription relies on conserved Sox motifs. Additionally, loss of Sox5 hinders the RGL activation driven by neurogenic stimuli such as environmental enrichment. Altogether, our data suggest that SoxD genes are key mediators in the transition of adult RGLs from quiescence to an activated mitotic state under physiological situations.This work was funded by grants to A.V.M. from the Spanish MICINN (SAF2017-85717-R, PID2020-112989RB-I00) and F. Alicia Koplowitz (2018) and to H.M. from the Spanish MICINN (SAF2015-70433-R, PID2019- 111225RB-I00) and PROMETEO/2018/055 from Generalitat ValencianaPeer reviewedCell PressMinisterio de Ciencia, Innovación y Universidades (España)Fundación Alicia KoplowitzGeneralitat ValencianaMinisterio de Economía y Competitividad (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202220222022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/261855reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020MICIU/ICTI2017‐2020info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020MICIU/ICTI2017‐2020info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016MINECO/ICTI2013‐2016info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020MICIU/ICTI2017‐2020https://dx.doi.org/10.1016/j.celrep.2022.110313Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2618552026-05-22T06:33:51Z
dc.title.none.fl_str_mv SoxD genes are required for adult neural stem cell activation
title SoxD genes are required for adult neural stem cell activation
spellingShingle SoxD genes are required for adult neural stem cell activation
Li, Lingling
Lamb-Shaffer syndrome
SOXopathy
Sox5
Sox6
Tolchin-Le Caignec syndrome
Adult neurogenesis
Hippocampus
Neural stem cells
Quiescence
title_short SoxD genes are required for adult neural stem cell activation
title_full SoxD genes are required for adult neural stem cell activation
title_fullStr SoxD genes are required for adult neural stem cell activation
title_full_unstemmed SoxD genes are required for adult neural stem cell activation
title_sort SoxD genes are required for adult neural stem cell activation
dc.creator.none.fl_str_mv Li, Lingling
Medina-Menéndez, Cristina
García-Corzo, Laura
Córdoba-Beldad, Carmen M.
Quiroga, Alejandra C.
Calleja Barca, Elena
Zinchuk, Valeriya
Muñoz-López, Sara
Rodríguez-Martín, Pilar
Ciorraga, Maria
Colmena, Inés
Fernández, Silvia
Vicario-Abejón, Carlos
Nicolis, Silvia K.
Lefebvre, Véronique
Mira, Helena
Morales, Aixa V.
author Li, Lingling
author_facet Li, Lingling
Medina-Menéndez, Cristina
García-Corzo, Laura
Córdoba-Beldad, Carmen M.
Quiroga, Alejandra C.
Calleja Barca, Elena
Zinchuk, Valeriya
Muñoz-López, Sara
Rodríguez-Martín, Pilar
Ciorraga, Maria
Colmena, Inés
Fernández, Silvia
Vicario-Abejón, Carlos
Nicolis, Silvia K.
Lefebvre, Véronique
Mira, Helena
Morales, Aixa V.
author_role author
author2 Medina-Menéndez, Cristina
García-Corzo, Laura
Córdoba-Beldad, Carmen M.
Quiroga, Alejandra C.
Calleja Barca, Elena
Zinchuk, Valeriya
Muñoz-López, Sara
Rodríguez-Martín, Pilar
Ciorraga, Maria
Colmena, Inés
Fernández, Silvia
Vicario-Abejón, Carlos
Nicolis, Silvia K.
Lefebvre, Véronique
Mira, Helena
Morales, Aixa V.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Fundación Alicia Koplowitz
Generalitat Valenciana
Ministerio de Economía y Competitividad (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Lamb-Shaffer syndrome
SOXopathy
Sox5
Sox6
Tolchin-Le Caignec syndrome
Adult neurogenesis
Hippocampus
Neural stem cells
Quiescence
topic Lamb-Shaffer syndrome
SOXopathy
Sox5
Sox6
Tolchin-Le Caignec syndrome
Adult neurogenesis
Hippocampus
Neural stem cells
Quiescence
description 19 páginas, 6 figuras. Supplemental information can be found online at https://doi.org/10.1016/j. celrep.2022.110313.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/261855
url http://hdl.handle.net/10261/261855
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020MICIU/ICTI2017‐2020
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020MICIU/ICTI2017‐2020
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016MINECO/ICTI2013‐2016
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020MICIU/ICTI2017‐2020
https://dx.doi.org/10.1016/j.celrep.2022.110313
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Cell Press
publisher.none.fl_str_mv Cell Press
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
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