Adaptation of the human gut microbiota metabolic network during the first year after birth

Fuertes, A. (Alvaro)|||/items/c242f7f1-33d0-4dc6-91d9-8c7ca0cfeff6; Pérez-Burillo, S. (Sergio)|||/items/f693a845-e93f-45a7-80a5-d4e63a300f18; Apaolaza-Emparanza, I.(Iñigo)|||/items/2a505211-8ceb-4c53-a1bc-5fce2aabbf50; Vallès, Y. (Yvonne)|||/items/1f27214d-33e0-4c06-a3b9-53be21a5c49c; Francino, M.P. (M. Pilar)|||/items/7da65cad-65d1-4cbc-b71c-b2362bd38f04; Rufián-Henares, J.Á. (Ángel José)|||/items/e6bc3d5e-2e59-491b-8075-528a4288a5cf; Planes-Pedreño, F.J. (Francisco Javier)|||/items/3234f2e5-4407-41e9-9058-1834965f6afa

Adaptation of the human gut microbiota metabolic network during the first year after birth

Predicting the metabolic behavior of the human gut microbiota in different contexts is one of the most promising areas of constraint-based modeling. Recently, we presented a supra-organismal approach to build context-specific metabolic networks of bacterial communities using functional and taxonomic...

Descripción completa

Detalles Bibliográficos
Autores:	Fuertes, A. (Alvaro)\|\|\|/items/c242f7f1-33d0-4dc6-91d9-8c7ca0cfeff6, Pérez-Burillo, S. (Sergio)\|\|\|/items/f693a845-e93f-45a7-80a5-d4e63a300f18, Apaolaza-Emparanza, I.(Iñigo)\|\|\|/items/2a505211-8ceb-4c53-a1bc-5fce2aabbf50, Vallès, Y. (Yvonne)\|\|\|/items/1f27214d-33e0-4c06-a3b9-53be21a5c49c, Francino, M.P. (M. Pilar)\|\|\|/items/7da65cad-65d1-4cbc-b71c-b2362bd38f04, Rufián-Henares, J.Á. (Ángel José)\|\|\|/items/e6bc3d5e-2e59-491b-8075-528a4288a5cf, Planes-Pedreño, F.J. (Francisco Javier)\|\|\|/items/3234f2e5-4407-41e9-9058-1834965f6afa
Tipo de recurso:	artículo
Fecha de publicación:	2019
País:	España
Institución:	Universidad de Navarra
Repositorio:	Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:	inglés
OAI Identifier:	oai:dadun.unav.edu:10171/63686
Acceso en línea:	https://hdl.handle.net/10171/63686
Access Level:	acceso abierto
Palabra clave:	Personalized nutrition Metabolic networks Human gut microbiome Metagenomics Metabolomics

id	ES_e419b072f8a36e8a1c345afe6d05141e
oai_identifier_str	oai:dadun.unav.edu:10171/63686
network_acronym_str	ES
network_name_str	España
repository_id_str
spelling	Adaptation of the human gut microbiota metabolic network during the first year after birthFuertes, A. (Alvaro)\|\|\|/items/c242f7f1-33d0-4dc6-91d9-8c7ca0cfeff6Pérez-Burillo, S. (Sergio)\|\|\|/items/f693a845-e93f-45a7-80a5-d4e63a300f18Apaolaza-Emparanza, I.(Iñigo)\|\|\|/items/2a505211-8ceb-4c53-a1bc-5fce2aabbf50Vallès, Y. (Yvonne)\|\|\|/items/1f27214d-33e0-4c06-a3b9-53be21a5c49cFrancino, M.P. (M. Pilar)\|\|\|/items/7da65cad-65d1-4cbc-b71c-b2362bd38f04Rufián-Henares, J.Á. (Ángel José)\|\|\|/items/e6bc3d5e-2e59-491b-8075-528a4288a5cfPlanes-Pedreño, F.J. (Francisco Javier)\|\|\|/items/3234f2e5-4407-41e9-9058-1834965f6afaPersonalized nutritionMetabolic networksHuman gut microbiomeMetagenomicsMetabolomicsPredicting the metabolic behavior of the human gut microbiota in different contexts is one of the most promising areas of constraint-based modeling. Recently, we presented a supra-organismal approach to build context-specific metabolic networks of bacterial communities using functional and taxonomic assignments of meta-omics data. In this work, this algorithm is applied to elucidate the metabolic changes induced over the first year after birth in the gut microbiota of a cohort of Spanish infants. We used metagenomics data of fecal samples and nutritional data of 13 infants at five time points. The resulting networks for each time point were analyzed, finding significant alterations once solid food is introduced in the diet. Our work shows that solid food leads to a different pattern of output metabolites that can be potentially released from the gut microbiota to the host. Experimental validation is presented for ferulate, a neuroprotective metabolite involved in the gut-brain axis.Frontiers Media SADadun. Depósito Académico Digital Universidad de Navarra20222022-06-2720192019-01-0120192019-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/63686reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/636862026-06-21T12:47:57Z
dc.title.none.fl_str_mv	Adaptation of the human gut microbiota metabolic network during the first year after birth
title	Adaptation of the human gut microbiota metabolic network during the first year after birth
spellingShingle	Adaptation of the human gut microbiota metabolic network during the first year after birth Fuertes, A. (Alvaro)\|\|\|/items/c242f7f1-33d0-4dc6-91d9-8c7ca0cfeff6 Personalized nutrition Metabolic networks Human gut microbiome Metagenomics Metabolomics
title_short	Adaptation of the human gut microbiota metabolic network during the first year after birth
title_full	Adaptation of the human gut microbiota metabolic network during the first year after birth
title_fullStr	Adaptation of the human gut microbiota metabolic network during the first year after birth
title_full_unstemmed	Adaptation of the human gut microbiota metabolic network during the first year after birth
title_sort	Adaptation of the human gut microbiota metabolic network during the first year after birth
dc.creator.none.fl_str_mv	Fuertes, A. (Alvaro)\|\|\|/items/c242f7f1-33d0-4dc6-91d9-8c7ca0cfeff6 Pérez-Burillo, S. (Sergio)\|\|\|/items/f693a845-e93f-45a7-80a5-d4e63a300f18 Apaolaza-Emparanza, I.(Iñigo)\|\|\|/items/2a505211-8ceb-4c53-a1bc-5fce2aabbf50 Vallès, Y. (Yvonne)\|\|\|/items/1f27214d-33e0-4c06-a3b9-53be21a5c49c Francino, M.P. (M. Pilar)\|\|\|/items/7da65cad-65d1-4cbc-b71c-b2362bd38f04 Rufián-Henares, J.Á. (Ángel José)\|\|\|/items/e6bc3d5e-2e59-491b-8075-528a4288a5cf Planes-Pedreño, F.J. (Francisco Javier)\|\|\|/items/3234f2e5-4407-41e9-9058-1834965f6afa
author	Fuertes, A. (Alvaro)\|\|\|/items/c242f7f1-33d0-4dc6-91d9-8c7ca0cfeff6
author_facet	Fuertes, A. (Alvaro)\|\|\|/items/c242f7f1-33d0-4dc6-91d9-8c7ca0cfeff6 Pérez-Burillo, S. (Sergio)\|\|\|/items/f693a845-e93f-45a7-80a5-d4e63a300f18 Apaolaza-Emparanza, I.(Iñigo)\|\|\|/items/2a505211-8ceb-4c53-a1bc-5fce2aabbf50 Vallès, Y. (Yvonne)\|\|\|/items/1f27214d-33e0-4c06-a3b9-53be21a5c49c Francino, M.P. (M. Pilar)\|\|\|/items/7da65cad-65d1-4cbc-b71c-b2362bd38f04 Rufián-Henares, J.Á. (Ángel José)\|\|\|/items/e6bc3d5e-2e59-491b-8075-528a4288a5cf Planes-Pedreño, F.J. (Francisco Javier)\|\|\|/items/3234f2e5-4407-41e9-9058-1834965f6afa
author_role	author
author2	Pérez-Burillo, S. (Sergio)\|\|\|/items/f693a845-e93f-45a7-80a5-d4e63a300f18 Apaolaza-Emparanza, I.(Iñigo)\|\|\|/items/2a505211-8ceb-4c53-a1bc-5fce2aabbf50 Vallès, Y. (Yvonne)\|\|\|/items/1f27214d-33e0-4c06-a3b9-53be21a5c49c Francino, M.P. (M. Pilar)\|\|\|/items/7da65cad-65d1-4cbc-b71c-b2362bd38f04 Rufián-Henares, J.Á. (Ángel José)\|\|\|/items/e6bc3d5e-2e59-491b-8075-528a4288a5cf Planes-Pedreño, F.J. (Francisco Javier)\|\|\|/items/3234f2e5-4407-41e9-9058-1834965f6afa
author2_role	author author author author author author
dc.contributor.none.fl_str_mv	Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv	Personalized nutrition Metabolic networks Human gut microbiome Metagenomics Metabolomics
topic	Personalized nutrition Metabolic networks Human gut microbiome Metagenomics Metabolomics
description	Predicting the metabolic behavior of the human gut microbiota in different contexts is one of the most promising areas of constraint-based modeling. Recently, we presented a supra-organismal approach to build context-specific metabolic networks of bacterial communities using functional and taxonomic assignments of meta-omics data. In this work, this algorithm is applied to elucidate the metabolic changes induced over the first year after birth in the gut microbiota of a cohort of Spanish infants. We used metagenomics data of fecal samples and nutritional data of 13 infants at five time points. The resulting networks for each time point were analyzed, finding significant alterations once solid food is introduced in the diet. Our work shows that solid food leads to a different pattern of output metabolites that can be potentially released from the gut microbiota to the host. Experimental validation is presented for ferulate, a neuroprotective metabolite involved in the gut-brain axis.
publishDate	2019
dc.date.none.fl_str_mv	2019 2019-01-01 2019 2019-01-01 2022 2022-06-27
dc.type.none.fl_str_mv	journal article http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/10171/63686
url	https://hdl.handle.net/10171/63686
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	Frontiers Media SA
publisher.none.fl_str_mv	Frontiers Media SA
dc.source.none.fl_str_mv	reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra
instname_str	Universidad de Navarra
reponame_str	Dadun. Depósito Académico Digital de la Universidad de Navarra
collection	Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_	1869422561451835392
score	15.300719

Adaptation of the human gut microbiota metabolic network during the first year after birth

Similares en LA Referencia