Diagnostic value of quantitative SPECT/CT in assessing active sacroiliitis in patients with axial spondylarthritis and/or inflammatory low back pain

Background. The diagnostic accuracy of bone scintigraphy (BS) increases with SPECT/CT imaging. It would therefore be appropriate to reassess the diagnostic utility of scintigraphy in sacroiliitis with axial spondyloarthritis (SpA). The aim of this study was to compare the diagnostic performance of M...

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Autores: Ornilla-Laraudogoitia, E.T. (Enrique Tomás)|||/items/55c9f926-6ab5-49a9-b92c-72f4a51d8281, Beorlegui, C. (Carmen)|||/items/9bece8df-075b-46d1-bb24-938b3151be0f, Ribelles, M.J. (María Jesús)|||/items/50c3a633-84e5-48f5-ab9b-19378abe45d6, Aquerreta-Beola, J.D. (Jesús Dámaso)|||/items/4e22c489-21cd-439a-808b-498365a8e461, Bondia, J.M. (J. M.)|||/items/ede8965b-5848-4985-84a0-d60e0f30e386, Cuadrado-Lozano, M.J. (María José)|||/items/b7d25985-2b88-4c94-a093-20ed3437d016, Sancho-Seuma, L. (Luis)|||/items/957375dd-76f2-452a-8386-b781e0e63806, Richter, J.A. (José Ángel)|||/items/4b21b403-ba6f-4220-8493-3453c8f876c3, Prieto-Azcárate, E. (Elena)|||/items/98983a2a-3ce1-471b-8174-68cd47fc9fcb
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/64417
Acceso en línea:https://hdl.handle.net/10171/64417
Access Level:acceso abierto
Palabra clave:Diagnóstico
Sacroilitis
Espondiloartritis
Gammagrafía
Resonancia magnética
Diagnoses
Sacroiliitis
Spondyloarthritis
Bone scintigraphy
Magnetic resonance imaging
Reumatología
Descripción
Sumario:Background. The diagnostic accuracy of bone scintigraphy (BS) increases with SPECT/CT imaging. It would therefore be appropriate to reassess the diagnostic utility of scintigraphy in sacroiliitis with axial spondyloarthritis (SpA). The aim of this study was to compare the diagnostic performance of MRI, SPECT/CT and a combination of both techniques in sacroiliitis, and to evaluate the correlation between quantitative SPECT/CT indices and quantitative MRI inflammatory lesion scores. Methods. Thirty-one patients with active SpA and 22 patients with inflammatory low back pain underwent MRI and SPECT/CT of the sacroiliac joints. The diagnostic accuracy of both techniques was calculated using clinical diagnosis as the gold standard. The correlation between MRI and SPECT/CT was calculated by comparing the SPECT/CT activity indices and the Berlin/SPARCC scoring systems for MRI. Results. The sensitivity and specificity values in quantitative SPECT/CT, taking the sacroiliac/promontory ratio of >1.36 as the cut-off value, were close to those from MRI published in the literature. The combination of both techniques increased sensitivity while maintaining high specificity. There was a moderate correlation between SPECT/CT and MRI total scores. This correlation was improved by using solely the MRI inflammation scores. Conclusion. Quantitative SPECT/CT showed better diagnostic accuracy than planar scintigraphy and showed a moderate correlation with MRI scores in active sacroiliitis. The combination of both tests increased the diagnostic accuracy. Quantitative SPECT/CT could play a relevant role in the diagnosis of active sacroiliitis in patients with high a suspicion of SpA and a negative/inconclusive MRI test or in patients with whom MRI studies cannot be carried out.

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