Intensive Weight-Loss Lifestyle Intervention Using Mediterranean Diet and COVID-19 Risk in Older Adults: Secondary Analysis of PREDIMED-Plus Trial
ObjectivesWe tested the effects of a weight-loss intervention encouraging energy-reduced MedDiet and physical activity (PA) in comparison to ad libitum MedDiet on COVID-19 incidence in older adults.DesignSecondary analysis of PREDIMED-Plus, a prospective, ongoing, multicentre randomized controlled t...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL) |
| Repositorio: | r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante |
| OAI Identifier: | oai:isabial.fundanetsuite.com:p9998 |
| Acceso en línea: | https://isabial.portalinvestigacion.com/publicaciones9998 |
| Access Level: | acceso abierto |
| Palabra clave: | COVID-19 SARS-CoV2 PREDIMED-Plus Mediterranean diet Older adults |
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Intensive Weight-Loss Lifestyle Intervention Using Mediterranean Diet and COVID-19 Risk in Older Adults: Secondary Analysis of PREDIMED-Plus TrialShyam, SGarcía-Gavilán, JFPaz-Graniel, IGaforio, JJMartínez-González, MACorella, DMartínez, JAAlonso-Gómez, AMWarnberg, JVioque, JRomaguera, DLópez-Miranda, JEstruch, RTinahones, FJLapetra, JSerra-Majem, JLBueno-Cavanillas, ATur, JASanchez, VMPinto, XMatía-Martín, PVidal, JAlcarria, MDDaimiel, LRos, EFernandez-Aranda, FNishi, SKGarcia-Regata, OAraluce, RPAsensio, EMCastaner, OGarcia-Rios, AOncina-Canovas, ABouzas, CZulet, MARayo, ECasas, RMartin-Pelaez, STojal-Sierra, LBernal-Lopez, MRCarlos, SSorli, JVGoday, APena-Orihuela, PJPastor-Morel, AEguaras, SZomeno, MDDelgado-Rodriguez, MBabio, NFito, MSalas-Salvado, JCOVID-19SARS-CoV2PREDIMED-PlusMediterranean dietOlder adultsObjectivesWe tested the effects of a weight-loss intervention encouraging energy-reduced MedDiet and physical activity (PA) in comparison to ad libitum MedDiet on COVID-19 incidence in older adults.DesignSecondary analysis of PREDIMED-Plus, a prospective, ongoing, multicentre randomized controlled trial.SettingCommunity-dwelling, free-living participants in PREDIMED-Plus trial.Participants6,874 Spanish older adults (55-75 years, 49% women) with overweight/obesity and metabolic syndrome.InterventionParticipants were randomised to Intervention (IG) or Control (CG) Group. IG received intensive behavioural intervention for weight loss with an energy-reduced MedDiet intervention and PA promotion. CG was encouraged to consume ad libitum MedDiet without PA recommendations.MeasurementsCOVID-19 was ascertained by an independent Event Committee until December 31, 2021. COX regression models compared the effect of PREDIMED-Plus interventions on COVID-19 risk.ResultsOverall, 653 COVID-19 incident cases were documented (IG:317; CG:336) over a median (IQR) follow-up of 5.8 (1.3) years (inclusive of 4.0 (1.2) years before community transmission of COVID-19) in both groups. A significantly lowered risk of COVID-19 incidence was not evident in IG, compared to CG (fully-adjusted HR (95% CI): 0.96 (0.81,1.12)).ConclusionsThere was no evidence to show that an intensive weight-loss intervention encouraging energy-reduced MedDiet and PA significantly lowered COVID-19 risk in older adults with overweight/ obesity and metabolic syndrome in comparison to ad libitum MedDiet. Recommendations to improve adherence to MedDiet provided with or without lifestyle modification suggestions for weight loss may have similar effects in protecting against COVID-19 risk in older adults with high cardiovascular risks.ELSEVIER SCIENCE INC2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://isabial.portalinvestigacion.com/publicaciones9998Journal of Nutrition Health & AgingISSN: 12797707ISSNe: 17604788reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicanteinstname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)Inglésinfo:eu-repo/semantics/openAccessoai:isabial.fundanetsuite.com:p99982026-06-12T10:20:37Z |
| dc.title.none.fl_str_mv |
Intensive Weight-Loss Lifestyle Intervention Using Mediterranean Diet and COVID-19 Risk in Older Adults: Secondary Analysis of PREDIMED-Plus Trial |
| title |
Intensive Weight-Loss Lifestyle Intervention Using Mediterranean Diet and COVID-19 Risk in Older Adults: Secondary Analysis of PREDIMED-Plus Trial |
| spellingShingle |
Intensive Weight-Loss Lifestyle Intervention Using Mediterranean Diet and COVID-19 Risk in Older Adults: Secondary Analysis of PREDIMED-Plus Trial Shyam, S COVID-19 SARS-CoV2 PREDIMED-Plus Mediterranean diet Older adults |
| title_short |
Intensive Weight-Loss Lifestyle Intervention Using Mediterranean Diet and COVID-19 Risk in Older Adults: Secondary Analysis of PREDIMED-Plus Trial |
| title_full |
Intensive Weight-Loss Lifestyle Intervention Using Mediterranean Diet and COVID-19 Risk in Older Adults: Secondary Analysis of PREDIMED-Plus Trial |
| title_fullStr |
Intensive Weight-Loss Lifestyle Intervention Using Mediterranean Diet and COVID-19 Risk in Older Adults: Secondary Analysis of PREDIMED-Plus Trial |
| title_full_unstemmed |
Intensive Weight-Loss Lifestyle Intervention Using Mediterranean Diet and COVID-19 Risk in Older Adults: Secondary Analysis of PREDIMED-Plus Trial |
| title_sort |
Intensive Weight-Loss Lifestyle Intervention Using Mediterranean Diet and COVID-19 Risk in Older Adults: Secondary Analysis of PREDIMED-Plus Trial |
| dc.creator.none.fl_str_mv |
Shyam, S García-Gavilán, JF Paz-Graniel, I Gaforio, JJ Martínez-González, MA Corella, D Martínez, JA Alonso-Gómez, AM Warnberg, J Vioque, J Romaguera, D López-Miranda, J Estruch, R Tinahones, FJ Lapetra, J Serra-Majem, JL Bueno-Cavanillas, A Tur, JA Sanchez, VM Pinto, X Matía-Martín, P Vidal, J Alcarria, MD Daimiel, L Ros, E Fernandez-Aranda, F Nishi, SK Garcia-Regata, O Araluce, RP Asensio, EM Castaner, O Garcia-Rios, A Oncina-Canovas, A Bouzas, C Zulet, MA Rayo, E Casas, R Martin-Pelaez, S Tojal-Sierra, L Bernal-Lopez, MR Carlos, S Sorli, JV Goday, A Pena-Orihuela, PJ Pastor-Morel, A Eguaras, S Zomeno, MD Delgado-Rodriguez, M Babio, N Fito, M Salas-Salvado, J |
| author |
Shyam, S |
| author_facet |
Shyam, S García-Gavilán, JF Paz-Graniel, I Gaforio, JJ Martínez-González, MA Corella, D Martínez, JA Alonso-Gómez, AM Warnberg, J Vioque, J Romaguera, D López-Miranda, J Estruch, R Tinahones, FJ Lapetra, J Serra-Majem, JL Bueno-Cavanillas, A Tur, JA Sanchez, VM Pinto, X Matía-Martín, P Vidal, J Alcarria, MD Daimiel, L Ros, E Fernandez-Aranda, F Nishi, SK Garcia-Regata, O Araluce, RP Asensio, EM Castaner, O Garcia-Rios, A Oncina-Canovas, A Bouzas, C Zulet, MA Rayo, E Casas, R Martin-Pelaez, S Tojal-Sierra, L Bernal-Lopez, MR Carlos, S Sorli, JV Goday, A Pena-Orihuela, PJ Pastor-Morel, A Eguaras, S Zomeno, MD Delgado-Rodriguez, M Babio, N Fito, M Salas-Salvado, J |
| author_role |
author |
| author2 |
García-Gavilán, JF Paz-Graniel, I Gaforio, JJ Martínez-González, MA Corella, D Martínez, JA Alonso-Gómez, AM Warnberg, J Vioque, J Romaguera, D López-Miranda, J Estruch, R Tinahones, FJ Lapetra, J Serra-Majem, JL Bueno-Cavanillas, A Tur, JA Sanchez, VM Pinto, X Matía-Martín, P Vidal, J Alcarria, MD Daimiel, L Ros, E Fernandez-Aranda, F Nishi, SK Garcia-Regata, O Araluce, RP Asensio, EM Castaner, O Garcia-Rios, A Oncina-Canovas, A Bouzas, C Zulet, MA Rayo, E Casas, R Martin-Pelaez, S Tojal-Sierra, L Bernal-Lopez, MR Carlos, S Sorli, JV Goday, A Pena-Orihuela, PJ Pastor-Morel, A Eguaras, S Zomeno, MD Delgado-Rodriguez, M Babio, N Fito, M Salas-Salvado, J |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
COVID-19 SARS-CoV2 PREDIMED-Plus Mediterranean diet Older adults |
| topic |
COVID-19 SARS-CoV2 PREDIMED-Plus Mediterranean diet Older adults |
| description |
ObjectivesWe tested the effects of a weight-loss intervention encouraging energy-reduced MedDiet and physical activity (PA) in comparison to ad libitum MedDiet on COVID-19 incidence in older adults.DesignSecondary analysis of PREDIMED-Plus, a prospective, ongoing, multicentre randomized controlled trial.SettingCommunity-dwelling, free-living participants in PREDIMED-Plus trial.Participants6,874 Spanish older adults (55-75 years, 49% women) with overweight/obesity and metabolic syndrome.InterventionParticipants were randomised to Intervention (IG) or Control (CG) Group. IG received intensive behavioural intervention for weight loss with an energy-reduced MedDiet intervention and PA promotion. CG was encouraged to consume ad libitum MedDiet without PA recommendations.MeasurementsCOVID-19 was ascertained by an independent Event Committee until December 31, 2021. COX regression models compared the effect of PREDIMED-Plus interventions on COVID-19 risk.ResultsOverall, 653 COVID-19 incident cases were documented (IG:317; CG:336) over a median (IQR) follow-up of 5.8 (1.3) years (inclusive of 4.0 (1.2) years before community transmission of COVID-19) in both groups. A significantly lowered risk of COVID-19 incidence was not evident in IG, compared to CG (fully-adjusted HR (95% CI): 0.96 (0.81,1.12)).ConclusionsThere was no evidence to show that an intensive weight-loss intervention encouraging energy-reduced MedDiet and PA significantly lowered COVID-19 risk in older adults with overweight/ obesity and metabolic syndrome in comparison to ad libitum MedDiet. Recommendations to improve adherence to MedDiet provided with or without lifestyle modification suggestions for weight loss may have similar effects in protecting against COVID-19 risk in older adults with high cardiovascular risks. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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https://isabial.portalinvestigacion.com/publicaciones9998 |
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https://isabial.portalinvestigacion.com/publicaciones9998 |
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Inglés |
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Inglés |
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info:eu-repo/semantics/openAccess |
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openAccess |
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ELSEVIER SCIENCE INC |
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ELSEVIER SCIENCE INC |
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Journal of Nutrition Health & Aging ISSN: 12797707 ISSNe: 17604788 reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante instname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL) |
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Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL) |
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r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante |
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r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante |
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