Ampicillin-resistant and vancomycin-susceptible Enterococcus faecium bacteremia: a clinical narrative review

Introduction: Enterococcus faecium is a commensal microorganism that can cause infections such as bacteremia. Incidence of ampicillin-resistant and vancomycin-susceptible E. faecium (EfARSV) bacteremia is on the rise, and the mortality rate is high. Despite much data, the most appropriate treatment...

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Autores: Echeverría Esnal, Daniel, Sorli Redó, M. Luisa, Navarrete Rouco, Maria Eugenia, Prim, Núria, Barceló-Vidal, Jaime, Conde Estévez, David, Milagro Montero, Maria, Martín-Ontiyuelo, Clara, Horcajada Gallego, Juan Pablo, Grau Cerrato, Santiago
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2023
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/60151
Acceso en línea:http://hdl.handle.net/10230/60151
http://dx.doi.org/10.1080/14787210.2023.2223977
Access Level:acceso abierto
Palabra clave:Bacteremia
Enterococcus faecium
Bloodstream infection
Daptomycin
Linezolid
Oritavancin
Teicoplanin
Vancomycin
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spelling Ampicillin-resistant and vancomycin-susceptible Enterococcus faecium bacteremia: a clinical narrative reviewEcheverría Esnal, DanielSorli Redó, M. LuisaNavarrete Rouco, Maria EugeniaPrim, NúriaBarceló-Vidal, JaimeConde Estévez, DavidMilagro Montero, MariaMartín-Ontiyuelo, ClaraHorcajada Gallego, Juan PabloGrau Cerrato, SantiagoBacteremiaEnterococcus faeciumBloodstream infectionDaptomycinLinezolidOritavancinTeicoplaninVancomycinIntroduction: Enterococcus faecium is a commensal microorganism that can cause infections such as bacteremia. Incidence of ampicillin-resistant and vancomycin-susceptible E. faecium (EfARSV) bacteremia is on the rise, and the mortality rate is high. Despite much data, the most appropriate treatment remains a question. Areas covered: This article mostly reviews the relevant aspects of EfARSV bacteremia: microbiology, gastrointestinal tract colonization and invasion, antibiotic resistance, epidemiology, risk factors, mortality, and treatment, including pharmacologic components of employed agents and related clinical evidence. A literature search was conducted on PubMed on 31 July 2022, which was updated on 15 November 2022. Expert opinion: EfARSV bacteremia presents high mortality. However, it is uncertain whether mortality is attributable to or a marker of severity/comorbidities. Considering its antibiotic resistance pattern, EfARSV is considered a difficult-to-treat microorganism. Glycopeptides have been used to treat EfARSV, with linezolid and daptomycin serving as potential alternative agents. Yet, the use of daptomycin is controversial due to a higher risk of treatment failures. Clinical evidence on this issue is scarce, unfortunately, and subject to many limitations. Despite increased incidence and mortality, EfARSV bacteremia presents multiple aspects to be addressed in well-conducted studies.Taylor & Francis20242023info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/60151http://dx.doi.org/10.1080/14787210.2023.2223977reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésExpert Rev Anti Infect Ther. 2023 Jul-Dec;21(7):759-75© This is an Accepted Manuscript of an article published by Taylor & Francis in Expert review of anti-infective therapy on 2023 Jul-Dec, available online: http://www.tandfonline.com/10.1080/14787210.2023.2223977.info:eu-repo/semantics/openAccessoai:recercat.cat:10230/601512026-05-29T05:05:01Z
dc.title.none.fl_str_mv Ampicillin-resistant and vancomycin-susceptible Enterococcus faecium bacteremia: a clinical narrative review
title Ampicillin-resistant and vancomycin-susceptible Enterococcus faecium bacteremia: a clinical narrative review
spellingShingle Ampicillin-resistant and vancomycin-susceptible Enterococcus faecium bacteremia: a clinical narrative review
Echeverría Esnal, Daniel
Bacteremia
Enterococcus faecium
Bloodstream infection
Daptomycin
Linezolid
Oritavancin
Teicoplanin
Vancomycin
title_short Ampicillin-resistant and vancomycin-susceptible Enterococcus faecium bacteremia: a clinical narrative review
title_full Ampicillin-resistant and vancomycin-susceptible Enterococcus faecium bacteremia: a clinical narrative review
title_fullStr Ampicillin-resistant and vancomycin-susceptible Enterococcus faecium bacteremia: a clinical narrative review
title_full_unstemmed Ampicillin-resistant and vancomycin-susceptible Enterococcus faecium bacteremia: a clinical narrative review
title_sort Ampicillin-resistant and vancomycin-susceptible Enterococcus faecium bacteremia: a clinical narrative review
dc.creator.none.fl_str_mv Echeverría Esnal, Daniel
Sorli Redó, M. Luisa
Navarrete Rouco, Maria Eugenia
Prim, Núria
Barceló-Vidal, Jaime
Conde Estévez, David
Milagro Montero, Maria
Martín-Ontiyuelo, Clara
Horcajada Gallego, Juan Pablo
Grau Cerrato, Santiago
author Echeverría Esnal, Daniel
author_facet Echeverría Esnal, Daniel
Sorli Redó, M. Luisa
Navarrete Rouco, Maria Eugenia
Prim, Núria
Barceló-Vidal, Jaime
Conde Estévez, David
Milagro Montero, Maria
Martín-Ontiyuelo, Clara
Horcajada Gallego, Juan Pablo
Grau Cerrato, Santiago
author_role author
author2 Sorli Redó, M. Luisa
Navarrete Rouco, Maria Eugenia
Prim, Núria
Barceló-Vidal, Jaime
Conde Estévez, David
Milagro Montero, Maria
Martín-Ontiyuelo, Clara
Horcajada Gallego, Juan Pablo
Grau Cerrato, Santiago
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Bacteremia
Enterococcus faecium
Bloodstream infection
Daptomycin
Linezolid
Oritavancin
Teicoplanin
Vancomycin
topic Bacteremia
Enterococcus faecium
Bloodstream infection
Daptomycin
Linezolid
Oritavancin
Teicoplanin
Vancomycin
description Introduction: Enterococcus faecium is a commensal microorganism that can cause infections such as bacteremia. Incidence of ampicillin-resistant and vancomycin-susceptible E. faecium (EfARSV) bacteremia is on the rise, and the mortality rate is high. Despite much data, the most appropriate treatment remains a question. Areas covered: This article mostly reviews the relevant aspects of EfARSV bacteremia: microbiology, gastrointestinal tract colonization and invasion, antibiotic resistance, epidemiology, risk factors, mortality, and treatment, including pharmacologic components of employed agents and related clinical evidence. A literature search was conducted on PubMed on 31 July 2022, which was updated on 15 November 2022. Expert opinion: EfARSV bacteremia presents high mortality. However, it is uncertain whether mortality is attributable to or a marker of severity/comorbidities. Considering its antibiotic resistance pattern, EfARSV is considered a difficult-to-treat microorganism. Glycopeptides have been used to treat EfARSV, with linezolid and daptomycin serving as potential alternative agents. Yet, the use of daptomycin is controversial due to a higher risk of treatment failures. Clinical evidence on this issue is scarce, unfortunately, and subject to many limitations. Despite increased incidence and mortality, EfARSV bacteremia presents multiple aspects to be addressed in well-conducted studies.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/60151
http://dx.doi.org/10.1080/14787210.2023.2223977
url http://hdl.handle.net/10230/60151
http://dx.doi.org/10.1080/14787210.2023.2223977
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Expert Rev Anti Infect Ther. 2023 Jul-Dec;21(7):759-75
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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