Maternal antioxidant status in early pregnancy and development of fetal complications in twin pregnancies: a pilot study

Twin pregnancies are increasing due to the rise in mothers’ childbearing age and have a higher risk of fetal growth restriction (FGR) and prematurity. Therefore, early prediction of these events is important. Our aim was to analyze in the first trimester of pregnancy a possible association between a...

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Autores: Ramiro Cortijo, David, Calle Fernández-Miranda, María de la, Rodríguez Rodríguez, Pilar, López de Pablo, Angel L, López Giménez, Rosario, Aguilera Gutiérrez, Yolanda, Martín Cabrejas, M. Ángeles, González, María del Carmen, Arribas Rodríguez, Silvia Magdalena
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/690824
Acceso en línea:http://hdl.handle.net/10486/690824
https://dx.doi.org/10.3390/antiox9040269
Access Level:acceso abierto
Palabra clave:antioxidants
cortisol
melatonin
prematurity
twin
gestations
FGR
Medicina
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spelling Maternal antioxidant status in early pregnancy and development of fetal complications in twin pregnancies: a pilot studyRamiro Cortijo, DavidCalle Fernández-Miranda, María de laRodríguez Rodríguez, PilarLópez de Pablo, Angel LLópez Giménez, RosarioAguilera Gutiérrez, YolandaMartín Cabrejas, M. ÁngelesGonzález, María del CarmenArribas Rodríguez, Silvia MagdalenaantioxidantscortisolmelatoninprematuritytwingestationsFGRMedicinaTwin pregnancies are increasing due to the rise in mothers’ childbearing age and have a higher risk of fetal growth restriction (FGR) and prematurity. Therefore, early prediction of these events is important. Our aim was to analyze in the first trimester of pregnancy a possible association between antioxidants, including melatonin, in maternal plasma and the development of fetal complications in twin pregnancies. A single-center, prospective, and observational study was performed in 104 twin-pregnant women. A blood sample was extracted between the 9th and the 11th week of gestation, and plasma was obtained. Antioxidants (thiols, reduced glutathione, phenolic compounds, catalase, superoxide dismutase) and oxidative damage biomarkers (carbonyl groups and malondialdehyde) were assessed by spectrophotometry, and global scores were calculated from these parameters (Antiox-S, Prooxy-S). Melatonin and cortisol were evaluated by a competitive immunoassay. In the first trimester of pregnancy, Antiox-S was significantly lower in women who developed FGR compared to those with normal fetal growth; plasma melatonin was significantly lower in women with preterm compared to those with full-term births and exhibited a positive correlation with birth weight. Maternal cortisol showed a negative correlation with birth weight. We conclude that, for twin gestations, maternal plasma antioxidant status and melatonin could be potential biomarkers to be included in algorithms to predict FGR and preterm laborThis research was funded by Universidad Autonoma de Madrid; Multidisciplinary Research Project, grant number CEMU, 2013-10 and Ministerio de Economia y Competitividad, grant number FEM2015-63631-RMDPIDepartamento de FisiologíaDepartamento de Medicina Preventiva y Salud Pública y MicrobiologíaDepartamento de Obstetricia y GinecologíaDepartamento de Química OrgánicaFacultad de MedicinaUAM. Departamento de Química Agrícola20202020-03-25research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/690824https://dx.doi.org/10.3390/antiox9040269reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/6908242026-06-23T12:46:27Z
dc.title.none.fl_str_mv Maternal antioxidant status in early pregnancy and development of fetal complications in twin pregnancies: a pilot study
title Maternal antioxidant status in early pregnancy and development of fetal complications in twin pregnancies: a pilot study
spellingShingle Maternal antioxidant status in early pregnancy and development of fetal complications in twin pregnancies: a pilot study
Ramiro Cortijo, David
antioxidants
cortisol
melatonin
prematurity
twin
gestations
FGR
Medicina
title_short Maternal antioxidant status in early pregnancy and development of fetal complications in twin pregnancies: a pilot study
title_full Maternal antioxidant status in early pregnancy and development of fetal complications in twin pregnancies: a pilot study
title_fullStr Maternal antioxidant status in early pregnancy and development of fetal complications in twin pregnancies: a pilot study
title_full_unstemmed Maternal antioxidant status in early pregnancy and development of fetal complications in twin pregnancies: a pilot study
title_sort Maternal antioxidant status in early pregnancy and development of fetal complications in twin pregnancies: a pilot study
dc.creator.none.fl_str_mv Ramiro Cortijo, David
Calle Fernández-Miranda, María de la
Rodríguez Rodríguez, Pilar
López de Pablo, Angel L
López Giménez, Rosario
Aguilera Gutiérrez, Yolanda
Martín Cabrejas, M. Ángeles
González, María del Carmen
Arribas Rodríguez, Silvia Magdalena
author Ramiro Cortijo, David
author_facet Ramiro Cortijo, David
Calle Fernández-Miranda, María de la
Rodríguez Rodríguez, Pilar
López de Pablo, Angel L
López Giménez, Rosario
Aguilera Gutiérrez, Yolanda
Martín Cabrejas, M. Ángeles
González, María del Carmen
Arribas Rodríguez, Silvia Magdalena
author_role author
author2 Calle Fernández-Miranda, María de la
Rodríguez Rodríguez, Pilar
López de Pablo, Angel L
López Giménez, Rosario
Aguilera Gutiérrez, Yolanda
Martín Cabrejas, M. Ángeles
González, María del Carmen
Arribas Rodríguez, Silvia Magdalena
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Fisiología
Departamento de Medicina Preventiva y Salud Pública y Microbiología
Departamento de Obstetricia y Ginecología
Departamento de Química Orgánica
Facultad de Medicina
UAM. Departamento de Química Agrícola
dc.subject.none.fl_str_mv antioxidants
cortisol
melatonin
prematurity
twin
gestations
FGR
Medicina
topic antioxidants
cortisol
melatonin
prematurity
twin
gestations
FGR
Medicina
description Twin pregnancies are increasing due to the rise in mothers’ childbearing age and have a higher risk of fetal growth restriction (FGR) and prematurity. Therefore, early prediction of these events is important. Our aim was to analyze in the first trimester of pregnancy a possible association between antioxidants, including melatonin, in maternal plasma and the development of fetal complications in twin pregnancies. A single-center, prospective, and observational study was performed in 104 twin-pregnant women. A blood sample was extracted between the 9th and the 11th week of gestation, and plasma was obtained. Antioxidants (thiols, reduced glutathione, phenolic compounds, catalase, superoxide dismutase) and oxidative damage biomarkers (carbonyl groups and malondialdehyde) were assessed by spectrophotometry, and global scores were calculated from these parameters (Antiox-S, Prooxy-S). Melatonin and cortisol were evaluated by a competitive immunoassay. In the first trimester of pregnancy, Antiox-S was significantly lower in women who developed FGR compared to those with normal fetal growth; plasma melatonin was significantly lower in women with preterm compared to those with full-term births and exhibited a positive correlation with birth weight. Maternal cortisol showed a negative correlation with birth weight. We conclude that, for twin gestations, maternal plasma antioxidant status and melatonin could be potential biomarkers to be included in algorithms to predict FGR and preterm labor
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-03-25
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/690824
https://dx.doi.org/10.3390/antiox9040269
url http://hdl.handle.net/10486/690824
https://dx.doi.org/10.3390/antiox9040269
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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