Risk of transmission of sporadic Creutzfeldt-Jakob disease by surgical procedures: systematic reviews and quality of evidence

BACKGROUND: Sporadic Creutzfeldt-Jakob disease (sCJD) is potentially transmissible to humans. OBJECTIVE: This study aimed to summarise and rate the quality of the evidence of the association between surgery and sCJD. DESIGN AND METHODS: Firstly, we conducted systematic reviews and meta-analyses of c...

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Authors: Garcia Lopez, Fernando Jose, Ruiz-Tovar, Maria, Almazan-Isla, Javier, Alcalde-Cabero, Enrique, Calero, Miguel, Pedro-Cuesta, Jesus de
Format: article
Publication Date:2017
Country:España
Institution:Instituto de Salud Carlos III (ISCIII)
Repository:Repisalud
Language:English
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/6629
Online Access:http://hdl.handle.net/20.500.12105/6629
Access Level:Open access
Keyword:Creutzfeldt-Jakob Syndrome
Female
Humans
Male
Middle Aged
Neurosurgical Procedures
Prion Diseases
Surgical Instruments
Surgical Procedures, Operative
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oai_identifier_str oai:repisalud.isciii.es:20.500.12105/6629
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spelling Risk of transmission of sporadic Creutzfeldt-Jakob disease by surgical procedures: systematic reviews and quality of evidenceGarcia Lopez, Fernando JoseRuiz-Tovar, MariaAlmazan-Isla, JavierAlcalde-Cabero, EnriqueCalero, MiguelPedro-Cuesta, Jesus deCreutzfeldt-Jakob SyndromeFemaleHumansMaleMiddle AgedNeurosurgical ProceduresPrion DiseasesSurgical InstrumentsSurgical Procedures, OperativeBACKGROUND: Sporadic Creutzfeldt-Jakob disease (sCJD) is potentially transmissible to humans. OBJECTIVE: This study aimed to summarise and rate the quality of the evidence of the association between surgery and sCJD. DESIGN AND METHODS: Firstly, we conducted systematic reviews and meta-analyses of case-control studies with major surgical procedures as exposures under study. To assess quality of evidence, we used the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach. Secondly, we conducted a systematic review of sCJD case reports after sharing neurosurgical instruments. RESULTS: Thirteen case-control studies met the inclusion criteria for the systematic review of case-control studies. sCJD was positively associated with heart surgery, heart and vascular surgery and eye surgery, negatively associated with tonsillectomy and appendectomy, and not associated with neurosurgery or unspecified major surgery. The overall quality of evidence was rated as very low. A single case-control study with a low risk of bias found a strong association between surgery conducted more than 20 years before disease onset and sCJD. Seven cases were described as potentially transmitted by reused neurosurgical instruments. CONCLUSION: The association between surgery and sCJD remains uncertain. Measures currently recommended for preventing sCJD transmission should be strongly maintained. Future studies should focus on the potential association between sCJD and surgery undergone a long time previously.20182018-11-1920172017-10-2620172017-10-26review articlehttp://purl.org/coar/resource_type/c_dcae04bcVoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.12105/6629reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/66292026-06-12T12:43:37Z
dc.title.none.fl_str_mv Risk of transmission of sporadic Creutzfeldt-Jakob disease by surgical procedures: systematic reviews and quality of evidence
title Risk of transmission of sporadic Creutzfeldt-Jakob disease by surgical procedures: systematic reviews and quality of evidence
spellingShingle Risk of transmission of sporadic Creutzfeldt-Jakob disease by surgical procedures: systematic reviews and quality of evidence
Garcia Lopez, Fernando Jose
Creutzfeldt-Jakob Syndrome
Female
Humans
Male
Middle Aged
Neurosurgical Procedures
Prion Diseases
Surgical Instruments
Surgical Procedures, Operative
title_short Risk of transmission of sporadic Creutzfeldt-Jakob disease by surgical procedures: systematic reviews and quality of evidence
title_full Risk of transmission of sporadic Creutzfeldt-Jakob disease by surgical procedures: systematic reviews and quality of evidence
title_fullStr Risk of transmission of sporadic Creutzfeldt-Jakob disease by surgical procedures: systematic reviews and quality of evidence
title_full_unstemmed Risk of transmission of sporadic Creutzfeldt-Jakob disease by surgical procedures: systematic reviews and quality of evidence
title_sort Risk of transmission of sporadic Creutzfeldt-Jakob disease by surgical procedures: systematic reviews and quality of evidence
dc.creator.none.fl_str_mv Garcia Lopez, Fernando Jose
Ruiz-Tovar, Maria
Almazan-Isla, Javier
Alcalde-Cabero, Enrique
Calero, Miguel
Pedro-Cuesta, Jesus de
author Garcia Lopez, Fernando Jose
author_facet Garcia Lopez, Fernando Jose
Ruiz-Tovar, Maria
Almazan-Isla, Javier
Alcalde-Cabero, Enrique
Calero, Miguel
Pedro-Cuesta, Jesus de
author_role author
author2 Ruiz-Tovar, Maria
Almazan-Isla, Javier
Alcalde-Cabero, Enrique
Calero, Miguel
Pedro-Cuesta, Jesus de
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Creutzfeldt-Jakob Syndrome
Female
Humans
Male
Middle Aged
Neurosurgical Procedures
Prion Diseases
Surgical Instruments
Surgical Procedures, Operative
topic Creutzfeldt-Jakob Syndrome
Female
Humans
Male
Middle Aged
Neurosurgical Procedures
Prion Diseases
Surgical Instruments
Surgical Procedures, Operative
description BACKGROUND: Sporadic Creutzfeldt-Jakob disease (sCJD) is potentially transmissible to humans. OBJECTIVE: This study aimed to summarise and rate the quality of the evidence of the association between surgery and sCJD. DESIGN AND METHODS: Firstly, we conducted systematic reviews and meta-analyses of case-control studies with major surgical procedures as exposures under study. To assess quality of evidence, we used the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach. Secondly, we conducted a systematic review of sCJD case reports after sharing neurosurgical instruments. RESULTS: Thirteen case-control studies met the inclusion criteria for the systematic review of case-control studies. sCJD was positively associated with heart surgery, heart and vascular surgery and eye surgery, negatively associated with tonsillectomy and appendectomy, and not associated with neurosurgery or unspecified major surgery. The overall quality of evidence was rated as very low. A single case-control study with a low risk of bias found a strong association between surgery conducted more than 20 years before disease onset and sCJD. Seven cases were described as potentially transmitted by reused neurosurgical instruments. CONCLUSION: The association between surgery and sCJD remains uncertain. Measures currently recommended for preventing sCJD transmission should be strongly maintained. Future studies should focus on the potential association between sCJD and surgery undergone a long time previously.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-10-26
2017
2017-10-26
2018
2018-11-19
dc.type.none.fl_str_mv review article
http://purl.org/coar/resource_type/c_dcae04bc
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/6629
url http://hdl.handle.net/20.500.12105/6629
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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