An appraisal of respiratory system compliance in mechanically ventilated covid-19 patients

Background: Heterogeneous respiratory system static compliance (CRS) values and levels of hypoxemia in patients with novel coronavirus disease (COVID-19) requiring mechanical ventilation have been reported in previous smallcase series or studies conducted at a national level. Methods: We designed a...

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Detalles Bibliográficos
Autores: Li Bassi, Gianluigi, Suen, Jacky Y., Dalton, Heidi J., White, Nicole, Shrapnel, Sally, Fanning, Jonathan P., Liquet, Benoît, Hinton, Samuel, Vuorinen, Aapeli, Booth, Gareth, Millar, Jonathan E., Forsyth, Simon, Panigada, Mauro, Laffey, John, Brodie, Daniel, Fan, Eddy, Torres Martí, Antoni, Chiumello, Davide, Corley, Amanda, Elhazmi, Alyaa, Hodgson, Carol, Ichiba, Shingo, Luna, Carlos M., Murthy, Srinivas, Nichol, Alistair, Yeung Ng, Pauline, Ogino, Mark, Pesenti, Antonio, Trieu, Huynh Trung, Fraser, John F., COVID-19 Critical Care Consortium
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/186681
Acceso en línea:https://hdl.handle.net/2445/186681
Access Level:acceso abierto
Palabra clave:COVID-19
SARS-CoV-2
Respiració artificial
Complicacions (Medicina)
Unitats de cures intensives
Assaigs clínics
Artificial respiration
Complications (Medicine)
Intensive care units
Clinical trials
Descripción
Sumario:Background: Heterogeneous respiratory system static compliance (CRS) values and levels of hypoxemia in patients with novel coronavirus disease (COVID-19) requiring mechanical ventilation have been reported in previous smallcase series or studies conducted at a national level. Methods: We designed a retrospective observational cohort study with rapid data gathering from the international COVID-19 Critical Care Consortium study to comprehensively describe CRS calculated as: tidal volume/[airway plateau pressure-positive end-expiratory pressure (PEEP)] and its association with ventilatory management and outcomes of COVID-19 patients on mechanical ventilation (MV), admitted to intensive care units (ICU) worldwide. Results: We studied 745 patients from 22 countries, who required admission to the ICU and MV from January 14 to December 31, 2020, and presented at least one value of CRS within the frst seven days of MV. Median (IQR) age was 62 (52-71), patients were predominantly males (68%) and from Europe/North and South America (88%). CRS, within 48 h from endotracheal intubation, was available in 649 patients and was neither associated with the duration from onset of symptoms to commencement of MV (p=0.417) nor with PaO2/FiO2 (p=0.100). Females presented lower CRS than males (95% CI of CRS diference between females-males: −11.8 to −7.4 mL/cmH2O p<0.001), and although females presented higher body mass index (BMI), association of BMI with CRS was marginal (p=0.139). Ventilatory management varied across CRS range, resulting in a signifcant association between CRS and driving pressure (estimated decrease −0.31 cmH2O/L per mL/cmH20 of CRS, 95% CI −0.48 to −0.14, p<0.001). Overall, 28-day ICU mortality, accounting for the competing risk of being discharged within the period, was 35.6% (SE 1.7). Cox proportional hazard analysis demonstrated that CRS (+10 mL/cm H2O) was only associated with being discharge from the ICU within 28 days (HR 1.14, 95% CI 1.02-1.28, p=0.018).

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