New approaches targeting brown adipose tissue transplantation as a therapy in obesity

Brown adipose tissue (BAT) is raising high expectations as a potential target in the fight against metabolic disorders such as obesity and type 2 diabetes. BAT utilizes fuels such as fatty acids to maintain body temperature by uncoupling mitochondrial electron transport to produce heat instead of AT...

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Autores: Soler Vázquez, M. Carmen, Mera Nanín, Paula, Zagmutt Caroxa, Sebastián, Serra i Cucurull, Dolors, Herrero Rodríguez, Laura
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2018
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/127852
Acceso en línea:https://hdl.handle.net/2445/127852
Access Level:acceso abierto
Palabra clave:Teixit adipós
Trasplantament d'òrgans
Obesitat
Trastorns del metabolisme
Adipose tissues
Transplantation of organs
Obesity
Disorders of metabolism
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spelling New approaches targeting brown adipose tissue transplantation as a therapy in obesitySoler Vázquez, M. CarmenMera Nanín, PaulaZagmutt Caroxa, SebastiánSerra i Cucurull, DolorsHerrero Rodríguez, LauraTeixit adipósTrasplantament d'òrgansObesitatTrastorns del metabolismeAdipose tissuesTransplantation of organsObesityDisorders of metabolismBrown adipose tissue (BAT) is raising high expectations as a potential target in the fight against metabolic disorders such as obesity and type 2 diabetes. BAT utilizes fuels such as fatty acids to maintain body temperature by uncoupling mitochondrial electron transport to produce heat instead of ATP. This process is called thermogenesis. BAT was considered to be exclusive to rodents and human neonates. However, in the last decade several studies have demonstrated that BAT is not only present but also active in adult humans and that its activity is reduced in several pathological conditions, such as aging, obesity, and diabetes. Thus, tremendous efforts are being made by the scientific community to enhance either BAT mass or activity. Several activators of thermogenesis have been described, such as natriuretic peptides, bone morphogenic proteins, or fibroblast growth factor 21. Furthermore, recent studies have tested a therapeutic approach to directly increase BAT mass by the implantation of either adipocytes or fat tissue. This approach might have an important future in regenerative medicine and in the fight against metabolic disorders. Here, we review the emerging field of BAT transplantation including the various sources of mesenchymal stem cell isolation in rodents and humans and the described metabolic outcomes of adipocyte cell transplantation and BAT transplantation in obesity. KEYWORDS: Brown adipose tissue; Obesity; TransplantationElsevier B.V.2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/127852Articles publicats en revistes (Bioquímica i Fisiologia)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: https://doi.org/10.1016/j.bcp.2018.07.022Biochemical Pharmacology, 2018, vol. 155, p. 346-355https://doi.org/10.1016/j.bcp.2018.07.022cc-by-nc-nd (c) Elsevier B.V., 2018http://creativecommons.org/licenses/by-nc-nd/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1278522026-05-27T06:46:51Z
dc.title.none.fl_str_mv New approaches targeting brown adipose tissue transplantation as a therapy in obesity
title New approaches targeting brown adipose tissue transplantation as a therapy in obesity
spellingShingle New approaches targeting brown adipose tissue transplantation as a therapy in obesity
Soler Vázquez, M. Carmen
Teixit adipós
Trasplantament d'òrgans
Obesitat
Trastorns del metabolisme
Adipose tissues
Transplantation of organs
Obesity
Disorders of metabolism
title_short New approaches targeting brown adipose tissue transplantation as a therapy in obesity
title_full New approaches targeting brown adipose tissue transplantation as a therapy in obesity
title_fullStr New approaches targeting brown adipose tissue transplantation as a therapy in obesity
title_full_unstemmed New approaches targeting brown adipose tissue transplantation as a therapy in obesity
title_sort New approaches targeting brown adipose tissue transplantation as a therapy in obesity
dc.creator.none.fl_str_mv Soler Vázquez, M. Carmen
Mera Nanín, Paula
Zagmutt Caroxa, Sebastián
Serra i Cucurull, Dolors
Herrero Rodríguez, Laura
author Soler Vázquez, M. Carmen
author_facet Soler Vázquez, M. Carmen
Mera Nanín, Paula
Zagmutt Caroxa, Sebastián
Serra i Cucurull, Dolors
Herrero Rodríguez, Laura
author_role author
author2 Mera Nanín, Paula
Zagmutt Caroxa, Sebastián
Serra i Cucurull, Dolors
Herrero Rodríguez, Laura
author2_role author
author
author
author
dc.subject.none.fl_str_mv Teixit adipós
Trasplantament d'òrgans
Obesitat
Trastorns del metabolisme
Adipose tissues
Transplantation of organs
Obesity
Disorders of metabolism
topic Teixit adipós
Trasplantament d'òrgans
Obesitat
Trastorns del metabolisme
Adipose tissues
Transplantation of organs
Obesity
Disorders of metabolism
description Brown adipose tissue (BAT) is raising high expectations as a potential target in the fight against metabolic disorders such as obesity and type 2 diabetes. BAT utilizes fuels such as fatty acids to maintain body temperature by uncoupling mitochondrial electron transport to produce heat instead of ATP. This process is called thermogenesis. BAT was considered to be exclusive to rodents and human neonates. However, in the last decade several studies have demonstrated that BAT is not only present but also active in adult humans and that its activity is reduced in several pathological conditions, such as aging, obesity, and diabetes. Thus, tremendous efforts are being made by the scientific community to enhance either BAT mass or activity. Several activators of thermogenesis have been described, such as natriuretic peptides, bone morphogenic proteins, or fibroblast growth factor 21. Furthermore, recent studies have tested a therapeutic approach to directly increase BAT mass by the implantation of either adipocytes or fat tissue. This approach might have an important future in regenerative medicine and in the fight against metabolic disorders. Here, we review the emerging field of BAT transplantation including the various sources of mesenchymal stem cell isolation in rodents and humans and the described metabolic outcomes of adipocyte cell transplantation and BAT transplantation in obesity. KEYWORDS: Brown adipose tissue; Obesity; Transplantation
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/127852
url https://hdl.handle.net/2445/127852
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1016/j.bcp.2018.07.022
Biochemical Pharmacology, 2018, vol. 155, p. 346-355
https://doi.org/10.1016/j.bcp.2018.07.022
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Elsevier B.V., 2018
http://creativecommons.org/licenses/by-nc-nd/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Elsevier B.V., 2018
http://creativecommons.org/licenses/by-nc-nd/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv Articles publicats en revistes (Bioquímica i Fisiologia)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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