Prognostic Role of the Red Blood Cell Distribution Width (RDW) in Hodgkin Lymphoma

Simple Summary The red blood cell distribution width (RDW) increases in inflammatory conditions and is described as having a prognostic role in different types of cancer. As Hodgkin lymphoma (HL) has a proinflammatory background, we aim to study the prognostic role of RDW in HL. We report in a large...

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Autores: Herraez Balanzat, Ines, Bento, Leyre, del Campo Garcia, Raquel, Sas-Barbeito, Adriana, Ramos-Asensio, Rafael, Fernandez, Teresa, Mestre, Francesc, Alemany, Regina, Bargay Lleonart, Joan, Sampol Mayol, Antonia, Gutierrez, Antonio
Formato: artículo
Fecha de publicación:2020
País:España
Recursos:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/23003
Acesso em linha:https://hdl.handle.net/20.500.12105/23003
Access Level:acceso abierto
Palavra-chave:Hodgkin lymphoma
RDW
Risk factors
Survival
Secondary malignancies
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spelling Prognostic Role of the Red Blood Cell Distribution Width (RDW) in Hodgkin LymphomaHerraez Balanzat, InesBento, Leyredel Campo Garcia, RaquelSas-Barbeito, AdrianaRamos-Asensio, RafaelFernandez, TeresaMestre, FrancescAlemany, ReginaBargay Lleonart, JoanSampol Mayol, AntoniaGutierrez, AntonioHodgkin lymphomaRDWRisk factorsSurvivalSecondary malignanciesSimple Summary The red blood cell distribution width (RDW) increases in inflammatory conditions and is described as having a prognostic role in different types of cancer. As Hodgkin lymphoma (HL) has a proinflammatory background, we aim to study the prognostic role of RDW in HL. We report in a large retrospective series of homogenously treated HL, for the first time, that RDW is a simple, cheap, and easily available prognostic factor in HL, that identifies a group with worse EFS, OS, and a higher potential incidence of secondary malignancies. RDW seems to be related to most adverse prognostic factors in HL and this may make RDW a good candidate to be included in current or new prognostic scores for HL. The red blood cell distribution width (RDW) is a parameter available from an automated blood count, which measures the degree of heterogeneity of erythrocyte volume and increases in inflammatory conditions. The prognostic role of RDW has been described in different types of cancers. Hodgkin lymphoma (HL) is a hematological malignancy, known to have a proinflammatory background. We aim to study the prognostic role of RDW in HL. We retrospectively analyzed 264 patients with HL from two hospitals in the Balearic Islands between 1990 and 2018. Higher levels of RDW were independently related to anemia, B-symptoms, and low albumin. In age >= 45 years, the presence of lymphopenia and higher RDW were independently associated with worse event-free survival (EFS) and overall survival (OS). Long-term incidence of secondary malignancies was significantly higher in patients with higher RDW, particularly lung cancer. In conclusion, we report for the first time that RDW is a simple, cheap, and easily available prognostic factor in HL that identifies a group with worse EFS, OS, and a higher potential incidence of secondary malignancies. RDW seems to be related to most adverse prognostic factors in HL, making RDW an excellent candidate to be included in prognostic scores for HL.Multidisciplinary Digital Publishing Institute (MDPI)20242024-09-1320202020-11-0120202020-11-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articlehttps://hdl.handle.net/20.500.12105/23003reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/230032026-06-12T12:43:37Z
dc.title.none.fl_str_mv Prognostic Role of the Red Blood Cell Distribution Width (RDW) in Hodgkin Lymphoma
title Prognostic Role of the Red Blood Cell Distribution Width (RDW) in Hodgkin Lymphoma
spellingShingle Prognostic Role of the Red Blood Cell Distribution Width (RDW) in Hodgkin Lymphoma
Herraez Balanzat, Ines
Hodgkin lymphoma
RDW
Risk factors
Survival
Secondary malignancies
title_short Prognostic Role of the Red Blood Cell Distribution Width (RDW) in Hodgkin Lymphoma
title_full Prognostic Role of the Red Blood Cell Distribution Width (RDW) in Hodgkin Lymphoma
title_fullStr Prognostic Role of the Red Blood Cell Distribution Width (RDW) in Hodgkin Lymphoma
title_full_unstemmed Prognostic Role of the Red Blood Cell Distribution Width (RDW) in Hodgkin Lymphoma
title_sort Prognostic Role of the Red Blood Cell Distribution Width (RDW) in Hodgkin Lymphoma
dc.creator.none.fl_str_mv Herraez Balanzat, Ines
Bento, Leyre
del Campo Garcia, Raquel
Sas-Barbeito, Adriana
Ramos-Asensio, Rafael
Fernandez, Teresa
Mestre, Francesc
Alemany, Regina
Bargay Lleonart, Joan
Sampol Mayol, Antonia
Gutierrez, Antonio
author Herraez Balanzat, Ines
author_facet Herraez Balanzat, Ines
Bento, Leyre
del Campo Garcia, Raquel
Sas-Barbeito, Adriana
Ramos-Asensio, Rafael
Fernandez, Teresa
Mestre, Francesc
Alemany, Regina
Bargay Lleonart, Joan
Sampol Mayol, Antonia
Gutierrez, Antonio
author_role author
author2 Bento, Leyre
del Campo Garcia, Raquel
Sas-Barbeito, Adriana
Ramos-Asensio, Rafael
Fernandez, Teresa
Mestre, Francesc
Alemany, Regina
Bargay Lleonart, Joan
Sampol Mayol, Antonia
Gutierrez, Antonio
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Hodgkin lymphoma
RDW
Risk factors
Survival
Secondary malignancies
topic Hodgkin lymphoma
RDW
Risk factors
Survival
Secondary malignancies
description Simple Summary The red blood cell distribution width (RDW) increases in inflammatory conditions and is described as having a prognostic role in different types of cancer. As Hodgkin lymphoma (HL) has a proinflammatory background, we aim to study the prognostic role of RDW in HL. We report in a large retrospective series of homogenously treated HL, for the first time, that RDW is a simple, cheap, and easily available prognostic factor in HL, that identifies a group with worse EFS, OS, and a higher potential incidence of secondary malignancies. RDW seems to be related to most adverse prognostic factors in HL and this may make RDW a good candidate to be included in current or new prognostic scores for HL. The red blood cell distribution width (RDW) is a parameter available from an automated blood count, which measures the degree of heterogeneity of erythrocyte volume and increases in inflammatory conditions. The prognostic role of RDW has been described in different types of cancers. Hodgkin lymphoma (HL) is a hematological malignancy, known to have a proinflammatory background. We aim to study the prognostic role of RDW in HL. We retrospectively analyzed 264 patients with HL from two hospitals in the Balearic Islands between 1990 and 2018. Higher levels of RDW were independently related to anemia, B-symptoms, and low albumin. In age >= 45 years, the presence of lymphopenia and higher RDW were independently associated with worse event-free survival (EFS) and overall survival (OS). Long-term incidence of secondary malignancies was significantly higher in patients with higher RDW, particularly lung cancer. In conclusion, we report for the first time that RDW is a simple, cheap, and easily available prognostic factor in HL that identifies a group with worse EFS, OS, and a higher potential incidence of secondary malignancies. RDW seems to be related to most adverse prognostic factors in HL, making RDW an excellent candidate to be included in prognostic scores for HL.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-11-01
2020
2020-11-01
2024
2024-09-13
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.12105/23003
url https://hdl.handle.net/20.500.12105/23003
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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