Cell interactions in the control of size in Drosophila wings.

The vein locus (vn) includes lethal alleles (designated also defective dorsal discs) that prevent growth of dorsal discs and in viable genetic combinations reduce the number of cells of the adult wing. Those effects are prominent in genetic mosaics. Cell proliferation is reduced in all regions of th...

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Detalles Bibliográficos
Autores: García-Bellido, Antonio, Cortés, Fernando, Milán, Marco
Tipo de recurso: artículo
Fecha de publicación:1994
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/48009
Acceso en línea:http://hdl.handle.net/10261/48009
Access Level:acceso embargado
Palabra clave:Drosophila
Melanogaster
Wing
Disc
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spelling Cell interactions in the control of size in Drosophila wings.García-Bellido, AntonioCortés, FernandoMilán, MarcoDrosophilaMelanogasterWingDiscThe vein locus (vn) includes lethal alleles (designated also defective dorsal discs) that prevent growth of dorsal discs and in viable genetic combinations reduce the number of cells of the adult wing. Those effects are prominent in genetic mosaics. Cell proliferation is reduced in all regions of the wing blade in a local autonomous way. These effects are more extreme when mutant clones occupy full intervein regions bordering veins. Clones have, in addition, nonautonomous effects (accommodation) in the proliferation of wild-type cells of the same wing. These effects are more extreme in double mutant vn (ddd) and ve (rhomboid) allelic combinations. Developmental analysis shows that cell proliferation stops earlier in larval development the stronger the vn allele considered. A model is discussed of how cell proliferation is controlled by cellular interactions.Peer reviewedNational Academy of Sciences (U.S.)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201220121994info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501http://hdl.handle.net/10261/48009reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#http://dx.doi.org/10.1073/pnas.91.21.10222Síinfo:eu-repo/semantics/embargoedAccessoai:digital.csic.es:10261/480092026-05-22T06:33:51Z
dc.title.none.fl_str_mv Cell interactions in the control of size in Drosophila wings.
title Cell interactions in the control of size in Drosophila wings.
spellingShingle Cell interactions in the control of size in Drosophila wings.
García-Bellido, Antonio
Drosophila
Melanogaster
Wing
Disc
title_short Cell interactions in the control of size in Drosophila wings.
title_full Cell interactions in the control of size in Drosophila wings.
title_fullStr Cell interactions in the control of size in Drosophila wings.
title_full_unstemmed Cell interactions in the control of size in Drosophila wings.
title_sort Cell interactions in the control of size in Drosophila wings.
dc.creator.none.fl_str_mv García-Bellido, Antonio
Cortés, Fernando
Milán, Marco
author García-Bellido, Antonio
author_facet García-Bellido, Antonio
Cortés, Fernando
Milán, Marco
author_role author
author2 Cortés, Fernando
Milán, Marco
author2_role author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Drosophila
Melanogaster
Wing
Disc
topic Drosophila
Melanogaster
Wing
Disc
description The vein locus (vn) includes lethal alleles (designated also defective dorsal discs) that prevent growth of dorsal discs and in viable genetic combinations reduce the number of cells of the adult wing. Those effects are prominent in genetic mosaics. Cell proliferation is reduced in all regions of the wing blade in a local autonomous way. These effects are more extreme when mutant clones occupy full intervein regions bordering veins. Clones have, in addition, nonautonomous effects (accommodation) in the proliferation of wild-type cells of the same wing. These effects are more extreme in double mutant vn (ddd) and ve (rhomboid) allelic combinations. Developmental analysis shows that cell proliferation stops earlier in larval development the stronger the vn allele considered. A model is discussed of how cell proliferation is controlled by cellular interactions.
publishDate 1994
dc.date.none.fl_str_mv 1994
2012
2012
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/48009
url http://hdl.handle.net/10261/48009
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
http://dx.doi.org/10.1073/pnas.91.21.10222
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv embargoedAccess
dc.publisher.none.fl_str_mv National Academy of Sciences (U.S.)
publisher.none.fl_str_mv National Academy of Sciences (U.S.)
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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