The interplay between osteosarcopenia and intrinsic capacity: insights and associations with all-cause mortality in the Toledo study for healthy aging

BackgroundOsteosarcopenia—the coexistence of osteopenia/osteoporosis and sarcopenia—is associated with numerous adverse health outcomes, but its association with intrinsic capacity (IC) remains unknown. We aimed to explore the associations of osteosarcopenia with IC and all-cause mortality in older...

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Detalhes bibliográficos
Autores: Baltasar Fernández, Iván, Valenzuela Tallón, Pedro Luis, Rodríguez Gómez, Irene, Quiñonez Bareiro, Fabio, Alegre Durán, Luis María, Prokoipidis, Konstantinos, Rodríguez Mañas, Leocadio, Ara Royo, Ignacio, Rosas-Carrasco, Oscar, Williams, Lana, Ramírez-Vélez, Robinson, Pasco, Julie, Hajj-Boutros, Guy, Agnihotram, Raman, Sim, Marc, Lok, Wayne, Imani, Mahdi, Ayala-Copete, Ana María, Chabot, Julia, G. Borda, Miguel, J Neto, Nailton, Godard-Sebillotte, Claire, Bergman, Howard, Andrianova, Anna, Work, Soc, Arai, Hidenori, Gaudreau, Pierrette, Kung Chen, Liang, Samhat, Hussein, Kin, R., Da Silva Alexandre, Tiago, Guerra, Ricardo, Faust, Andréa, Papaioannou, Alexandra, Sekhon, Harmehr, Connolly, Emma, Duque, Gustavo, García García, Francisco José
Formato: artículo
Fecha de publicación:2026
País:España
Recursos:Universidad de Castilla-La Mancha
Repositorio:RUIdeRA. Repositorio Institucional de la UCLM
OAI Identifier:oai:dnet:ruidera_____::3866f277fca93afc1247835295e4d588
Acesso em linha:https://academic.oup.com/biomedgerontology/advance-article/doi/10.1093/gerona/glag090/8626955
https://hdl.handle.net/10578/48450
Access Level:acceso abierto
Palavra-chave:Adverse outcomes
Bone
Healthy aging
Muscle
Older adults
Descrição
Resumo:BackgroundOsteosarcopenia—the coexistence of osteopenia/osteoporosis and sarcopenia—is associated with numerous adverse health outcomes, but its association with intrinsic capacity (IC) remains unknown. We aimed to explore the associations of osteosarcopenia with IC and all-cause mortality in older adults.MethodsWe conducted a cross-sectional analysis of IC and a prospective analysis of all-cause mortality in 1142 participants from the Toledo Study for Healthy Aging (75.1±6.0 years, 53.1% women). Participants were classified as having no musculoskeletal disorders, osteopenia/osteoporosis, sarcopenia, or osteosarcopenia (DXA- and EWGSOP2-based criteria). IC was operationalized as a composite score integrating locomotion, cognition, psychological, vitality, and sensory domains.ResultsOlder adults with osteosarcopenia exhibited lower total IC (76.6±1.1 points) than those without musculoskeletal disorders (83.7±0.5 points; p<0.001) or with osteopenia/osteoporosis (81.3±0.3 points; p<0.001), with significant differences also found between the latter groups (p<0.001). Specifically, osteosarcopenia was associated with poorer results in the locomotion, cognition, vitality, and sensory domains (all p<0.01), but not in the psychological domain. Over a median 6.2-year follow-up, osteosarcopenia—but not osteopenia/osteoporosis—was associated with higher risk of mortality compared to those without musculoskeletal disorders [HR (95%CI)=1.96 (1.02–3.77); p=0.045]. In joint analyses with IC status (high vs. low, segregated by the median), this association was specifically observed among participants with osteosarcopenia and low IC [HR = 2.55 (1.31–4.96); p=0.004].ConclusionsOsteosarcopenia is associated with lower total IC and impairments across most IC domains. This finding is of clinical relevance, as the combination of this condition and low IC is associated with an increased mortality risk.

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