Uncovering the functional constraints underlying the genomic organisation of the Odorant-Binding Protein genes

Animal olfactory systems have a critical role for the survival and reproduction of individuals. In insects, the odorant-binding proteins (OBPs) are encoded by a moderately sized gene family, and mediate the first steps of the olfactory processing. Most OBPs are organized in clusters of a few paralog...

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Detalles Bibliográficos
Autores: Librado Sanz, Pablo, Rozas Liras, Julio A.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/53453
Acceso en línea:https://hdl.handle.net/2445/53453
Access Level:acceso abierto
Palabra clave:Genòmica
Olfacte
Nucleòtids
Genètica del desenvolupament
Genomics
Smell
Nucleotides
Developmental genetics
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spelling Uncovering the functional constraints underlying the genomic organisation of the Odorant-Binding Protein genesLibrado Sanz, PabloRozas Liras, Julio A.GenòmicaOlfacteNucleòtidsGenètica del desenvolupamentGenomicsSmellNucleotidesDevelopmental geneticsAnimal olfactory systems have a critical role for the survival and reproduction of individuals. In insects, the odorant-binding proteins (OBPs) are encoded by a moderately sized gene family, and mediate the first steps of the olfactory processing. Most OBPs are organized in clusters of a few paralogs, which are conserved over time. Currently, the biological mechanism explaining the close physical proximity among OBPs is not yet established. Here, we conducted a comprehensive study aiming to gain insights into the mechanisms underlying the OBP genomic organization. We found that the OBP clusters are embedded within large conserved arrangements. These organizations also include other non-OBP genes, which often encode proteins integral to plasma membrane. Moreover, the conservation degree of such large clusters is related to the following: 1) the promoter architecture of the confined genes, 2) a characteristic transcriptional environment, and 3) the chromatin conformation of the chromosomal region. Our results suggest that chromatin domains may restrict the location of OBP genes to regions having the appropriate transcriptional environment, leading to the OBP cluster structure. However, the appropriate transcriptional environment for OBP and the other neighbor genes is not dominated by reduced levels of expression noise. Indeed, the stochastic fluctuations in the OBP transcript abundance may have a critical role in the combinatorial nature of the olfactory coding process.Oxford University Press2013info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/53453Articles publicats en revistes (Genètica, Microbiologia i Estadística)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: http://dx.doi.org/10.1093/gbe/evt158Genome Biology and Evolution, 2013, vol. 5, num. 11, p. 2096-2108http://dx.doi.org/10.1093/gbe/evt158cc-by-nc (c) Librado Sanz, Pablo et al., 2013http://creativecommons.org/licenses/by-nc/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/534532026-05-27T06:46:51Z
dc.title.none.fl_str_mv Uncovering the functional constraints underlying the genomic organisation of the Odorant-Binding Protein genes
title Uncovering the functional constraints underlying the genomic organisation of the Odorant-Binding Protein genes
spellingShingle Uncovering the functional constraints underlying the genomic organisation of the Odorant-Binding Protein genes
Librado Sanz, Pablo
Genòmica
Olfacte
Nucleòtids
Genètica del desenvolupament
Genomics
Smell
Nucleotides
Developmental genetics
title_short Uncovering the functional constraints underlying the genomic organisation of the Odorant-Binding Protein genes
title_full Uncovering the functional constraints underlying the genomic organisation of the Odorant-Binding Protein genes
title_fullStr Uncovering the functional constraints underlying the genomic organisation of the Odorant-Binding Protein genes
title_full_unstemmed Uncovering the functional constraints underlying the genomic organisation of the Odorant-Binding Protein genes
title_sort Uncovering the functional constraints underlying the genomic organisation of the Odorant-Binding Protein genes
dc.creator.none.fl_str_mv Librado Sanz, Pablo
Rozas Liras, Julio A.
author Librado Sanz, Pablo
author_facet Librado Sanz, Pablo
Rozas Liras, Julio A.
author_role author
author2 Rozas Liras, Julio A.
author2_role author
dc.subject.none.fl_str_mv Genòmica
Olfacte
Nucleòtids
Genètica del desenvolupament
Genomics
Smell
Nucleotides
Developmental genetics
topic Genòmica
Olfacte
Nucleòtids
Genètica del desenvolupament
Genomics
Smell
Nucleotides
Developmental genetics
description Animal olfactory systems have a critical role for the survival and reproduction of individuals. In insects, the odorant-binding proteins (OBPs) are encoded by a moderately sized gene family, and mediate the first steps of the olfactory processing. Most OBPs are organized in clusters of a few paralogs, which are conserved over time. Currently, the biological mechanism explaining the close physical proximity among OBPs is not yet established. Here, we conducted a comprehensive study aiming to gain insights into the mechanisms underlying the OBP genomic organization. We found that the OBP clusters are embedded within large conserved arrangements. These organizations also include other non-OBP genes, which often encode proteins integral to plasma membrane. Moreover, the conservation degree of such large clusters is related to the following: 1) the promoter architecture of the confined genes, 2) a characteristic transcriptional environment, and 3) the chromatin conformation of the chromosomal region. Our results suggest that chromatin domains may restrict the location of OBP genes to regions having the appropriate transcriptional environment, leading to the OBP cluster structure. However, the appropriate transcriptional environment for OBP and the other neighbor genes is not dominated by reduced levels of expression noise. Indeed, the stochastic fluctuations in the OBP transcript abundance may have a critical role in the combinatorial nature of the olfactory coding process.
publishDate 2013
dc.date.none.fl_str_mv 2013
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/53453
url https://hdl.handle.net/2445/53453
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://dx.doi.org/10.1093/gbe/evt158
Genome Biology and Evolution, 2013, vol. 5, num. 11, p. 2096-2108
http://dx.doi.org/10.1093/gbe/evt158
dc.rights.none.fl_str_mv cc-by-nc (c) Librado Sanz, Pablo et al., 2013
http://creativecommons.org/licenses/by-nc/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc (c) Librado Sanz, Pablo et al., 2013
http://creativecommons.org/licenses/by-nc/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv Articles publicats en revistes (Genètica, Microbiologia i Estadística)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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