Effectiveness and persistence of golimumab as a second biological drug in patients with spondyloarthritis
This observational, longitudinal retrospective, noncomparative study was designed to assess the persistence and effectiveness of golimumab as a second anti-tumor necrosis factor (TNF) drug in patients with spondyloarthritis requiring discontinuation from a first anti-TNF drug.Data were collected ret...
| Autores: | , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Universidad de Barcelona |
| Repositorio: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/178784 |
| Acceso en línea: | https://hdl.handle.net/2445/178784 |
| Access Level: | acceso abierto |
| Palabra clave: | Espondiloartropaties Espondiloartritis anquilosant Administració de medicaments Assaigs clínics Spondyloarthropathies Ankylosing spondylitis Administration of drugs Clinical trials |
| id |
ES_e36b5d5a67a9f08e5d3a02a718568263 |
|---|---|
| oai_identifier_str |
oai:diposit.ub.edu:2445/178784 |
| network_acronym_str |
ES |
| network_name_str |
España |
| repository_id_str |
|
| spelling |
Effectiveness and persistence of golimumab as a second biological drug in patients with spondyloarthritisAlegre-Sancho, Juan JoséJuanola, XavierRodríguez Heredia, José M.Manero, JavierVilla Blanco, IgnacioLaiz, AnaArteaga, María J.Cea Calvo, LuisGonzález, Carlos M.EspondiloartropatiesEspondiloartritis anquilosantAdministració de medicamentsAssaigs clínicsSpondyloarthropathiesAnkylosing spondylitisAdministration of drugsClinical trialsThis observational, longitudinal retrospective, noncomparative study was designed to assess the persistence and effectiveness of golimumab as a second anti-tumor necrosis factor (TNF) drug in patients with spondyloarthritis requiring discontinuation from a first anti-TNF drug.Data were collected retrospectively for all patients with axial spondyloarthritis or psoriatic arthritis from 20 rheumatology clinics in Spain who started golimumab as a second anti-TNF drug between January 2013 and December 2015. Golimumab persistence was assessed with Kaplan-Meier survival analysis, and associated factors were assessed with Cox regression analysis.210 patients started golimumab as a second anti-TNF drug: 131 with axial spondyloarthritis and 79 with psoriatic arthritis. In axial spondyloarthritis patients, the mean (standard deviation) Bath Ankylosing Spondylitis Disease Activity Index score at baseline was 5.5 (2.1), decreasing to 3.9 (2.0) at month 3 and 3.5 (2.0) at year 1, and remaining stable thereafter. In psoriatic arthritis patients, mean (standard deviation) baseline Disease Activity Score was 4.0 (1.3), reducing to 2.5 (1.2) at month 3 and to 2.2 (1.3) at year 1. Corresponding improvements were recorded from baseline in C-reactive protein levels and erythrocyte sedimentation rates. The probability of persistence of treatment with golimumab was 80% at year 1, 70% at year 2 and 65% at years 3 and year 4, and was similar in those who had stopped the first anti-TNF due to loss of efficacy or other reasons. Cox regression analysis showed that the probability of survival with golimumab was higher in patients with higher erythrocyte sedimentation rate, in patients with axial spondyloarthritis than with psoriatic arthritis, and in those who had discontinued adalimumab as first anti-TNF. Seventy-two patients (34.3%) discontinued golimumab during follow-up, 50 of them due to lack of efficacy.In patients with spondyloarthritis requiring discontinuation from a first anti-TNF drug, treatment with golimumab was effective and showed a high probability of persistence up to 4 years of treatment.Ovid Technologies (Wolters Kluwer Health)2021info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2445/178784Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1097/MD.0000000000025223Medicine, 2021, vol. 100, issue. 13, p. e25223https://doi.org/10.1097/MD.0000000000025223cc by-nc (c) Alegre Sancho, Juan J. et al., 2021http://creativecommons.org/licenses/by-nc/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1787842026-05-27T06:46:51Z |
| dc.title.none.fl_str_mv |
Effectiveness and persistence of golimumab as a second biological drug in patients with spondyloarthritis |
| title |
Effectiveness and persistence of golimumab as a second biological drug in patients with spondyloarthritis |
| spellingShingle |
Effectiveness and persistence of golimumab as a second biological drug in patients with spondyloarthritis Alegre-Sancho, Juan José Espondiloartropaties Espondiloartritis anquilosant Administració de medicaments Assaigs clínics Spondyloarthropathies Ankylosing spondylitis Administration of drugs Clinical trials |
| title_short |
Effectiveness and persistence of golimumab as a second biological drug in patients with spondyloarthritis |
| title_full |
Effectiveness and persistence of golimumab as a second biological drug in patients with spondyloarthritis |
| title_fullStr |
Effectiveness and persistence of golimumab as a second biological drug in patients with spondyloarthritis |
| title_full_unstemmed |
Effectiveness and persistence of golimumab as a second biological drug in patients with spondyloarthritis |
| title_sort |
Effectiveness and persistence of golimumab as a second biological drug in patients with spondyloarthritis |
| dc.creator.none.fl_str_mv |
Alegre-Sancho, Juan José Juanola, Xavier Rodríguez Heredia, José M. Manero, Javier Villa Blanco, Ignacio Laiz, Ana Arteaga, María J. Cea Calvo, Luis González, Carlos M. |
| author |
Alegre-Sancho, Juan José |
| author_facet |
Alegre-Sancho, Juan José Juanola, Xavier Rodríguez Heredia, José M. Manero, Javier Villa Blanco, Ignacio Laiz, Ana Arteaga, María J. Cea Calvo, Luis González, Carlos M. |
| author_role |
author |
| author2 |
Juanola, Xavier Rodríguez Heredia, José M. Manero, Javier Villa Blanco, Ignacio Laiz, Ana Arteaga, María J. Cea Calvo, Luis González, Carlos M. |
| author2_role |
author author author author author author author author |
| dc.subject.none.fl_str_mv |
Espondiloartropaties Espondiloartritis anquilosant Administració de medicaments Assaigs clínics Spondyloarthropathies Ankylosing spondylitis Administration of drugs Clinical trials |
| topic |
Espondiloartropaties Espondiloartritis anquilosant Administració de medicaments Assaigs clínics Spondyloarthropathies Ankylosing spondylitis Administration of drugs Clinical trials |
| description |
This observational, longitudinal retrospective, noncomparative study was designed to assess the persistence and effectiveness of golimumab as a second anti-tumor necrosis factor (TNF) drug in patients with spondyloarthritis requiring discontinuation from a first anti-TNF drug.Data were collected retrospectively for all patients with axial spondyloarthritis or psoriatic arthritis from 20 rheumatology clinics in Spain who started golimumab as a second anti-TNF drug between January 2013 and December 2015. Golimumab persistence was assessed with Kaplan-Meier survival analysis, and associated factors were assessed with Cox regression analysis.210 patients started golimumab as a second anti-TNF drug: 131 with axial spondyloarthritis and 79 with psoriatic arthritis. In axial spondyloarthritis patients, the mean (standard deviation) Bath Ankylosing Spondylitis Disease Activity Index score at baseline was 5.5 (2.1), decreasing to 3.9 (2.0) at month 3 and 3.5 (2.0) at year 1, and remaining stable thereafter. In psoriatic arthritis patients, mean (standard deviation) baseline Disease Activity Score was 4.0 (1.3), reducing to 2.5 (1.2) at month 3 and to 2.2 (1.3) at year 1. Corresponding improvements were recorded from baseline in C-reactive protein levels and erythrocyte sedimentation rates. The probability of persistence of treatment with golimumab was 80% at year 1, 70% at year 2 and 65% at years 3 and year 4, and was similar in those who had stopped the first anti-TNF due to loss of efficacy or other reasons. Cox regression analysis showed that the probability of survival with golimumab was higher in patients with higher erythrocyte sedimentation rate, in patients with axial spondyloarthritis than with psoriatic arthritis, and in those who had discontinued adalimumab as first anti-TNF. Seventy-two patients (34.3%) discontinued golimumab during follow-up, 50 of them due to lack of efficacy.In patients with spondyloarthritis requiring discontinuation from a first anti-TNF drug, treatment with golimumab was effective and showed a high probability of persistence up to 4 years of treatment. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/178784 |
| url |
https://hdl.handle.net/2445/178784 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Reproducció del document publicat a: https://doi.org/10.1097/MD.0000000000025223 Medicine, 2021, vol. 100, issue. 13, p. e25223 https://doi.org/10.1097/MD.0000000000025223 |
| dc.rights.none.fl_str_mv |
cc by-nc (c) Alegre Sancho, Juan J. et al., 2021 http://creativecommons.org/licenses/by-nc/3.0/es/ info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
cc by-nc (c) Alegre Sancho, Juan J. et al., 2021 http://creativecommons.org/licenses/by-nc/3.0/es/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Ovid Technologies (Wolters Kluwer Health) |
| publisher.none.fl_str_mv |
Ovid Technologies (Wolters Kluwer Health) |
| dc.source.none.fl_str_mv |
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) reponame:Dipòsit Digital de la UB instname:Universidad de Barcelona |
| instname_str |
Universidad de Barcelona |
| reponame_str |
Dipòsit Digital de la UB |
| collection |
Dipòsit Digital de la UB |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1869422499490430976 |
| score |
15.301629 |