Synergic effect of corneal hysteresis and central corneal thickness in the risk of early‑stage primary open‑angle glaucoma progression

Purpose: To evaluate corneal hysteresis (CH), acquired with ocular response analyzer (ORA), as a risk factor for glaucoma progression in early-stage primary open-angle glaucoma (POAG). Methods: In a historical cohort study, patients diagnosed in 2011 with early-stage POAG according to the Hodapp, Pa...

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Autores: Jiménez Santos, María A., Sáenz Francés, Federico, Sánchez Jean, Rubén, Martínez De La Casa Fernández-Borrella, José María, García Feijoo, Julián, Jañez Escalada, Luis
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/8156
Acceso en línea:https://hdl.handle.net/20.500.14352/8156
Access Level:acceso abierto
Palabra clave:617.7‑007.681
612.841
Perimetry
Primary open-angle glaucoma
Progression
Corneal hysteresis
Risk factors
Oftalmología
3201.09 Oftalmología
id ES_e35e4792c151e399ee4afde203d8d4f2
oai_identifier_str oai:docta.ucm.es:20.500.14352/8156
network_acronym_str ES
network_name_str España
repository_id_str
spelling Synergic effect of corneal hysteresis and central corneal thickness in the risk of early‑stage primary open‑angle glaucoma progressionJiménez Santos, María A.Sáenz Francés, FedericoSánchez Jean, RubénMartínez De La Casa Fernández-Borrella, José MaríaGarcía Feijoo, JuliánJañez Escalada, Luis617.7‑007.681612.841PerimetryPrimary open-angle glaucomaProgressionCorneal hysteresisRisk factorsOftalmología3201.09 OftalmologíaPurpose: To evaluate corneal hysteresis (CH), acquired with ocular response analyzer (ORA), as a risk factor for glaucoma progression in early-stage primary open-angle glaucoma (POAG). Methods: In a historical cohort study, patients diagnosed in 2011 with early-stage POAG according to the Hodapp, Parrish and Anderson classification modified for Octopus perimetry and followed up until glaucomatous progression development; otherwise, observations were censored in October 2018. Cox regression was used to obtain hazard ratios (HR) to evaluate baseline variables (CH, central corneal thickness, gender, age IOP and glaucoma family history) as risk factors for perimetric glaucoma progression. A likelihood ratio test for interaction was performed in order to assess the effect of the combination of CH and CCT on the risk of progression. Results: Of the cohort of 1573 patients, 11.38% developed early-stage POAG progression during the follow-up. The mean follow-up time was 3.28 ± 1.92 years. Patients without progression had a higher CH (11.35 ± 1.43 vs 9.07 ± 1.69 mmHg; p < 0.001) and CCT (570.75 ± 17.71 vs 554.51 ± 23.20; p < 0.001). In the multivariate analysis, each 1 mmHg of lower CH was associated with an increase of 2.13 times in the HR of progression (95% CI: 1.92–2.32; p < 0.001). CH hazard ratio was modified by CCT, with higher values of CCT and CH resulting in a higher HR of early glaucoma progression (p < 0.001). Conclusions: CH can be considered as a risk factor of progression in early-stage POAG. The risk associated with CH changed depending on CCT values, acting synergistically slowing the risk of glaucoma progression with higher values.SpringerUniversidad Complutense de Madrid20212021-05-0720212021-05-07journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/8156reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/81562026-06-02T12:44:21Z
dc.title.none.fl_str_mv Synergic effect of corneal hysteresis and central corneal thickness in the risk of early‑stage primary open‑angle glaucoma progression
title Synergic effect of corneal hysteresis and central corneal thickness in the risk of early‑stage primary open‑angle glaucoma progression
spellingShingle Synergic effect of corneal hysteresis and central corneal thickness in the risk of early‑stage primary open‑angle glaucoma progression
Jiménez Santos, María A.
617.7‑007.681
612.841
Perimetry
Primary open-angle glaucoma
Progression
Corneal hysteresis
Risk factors
Oftalmología
3201.09 Oftalmología
title_short Synergic effect of corneal hysteresis and central corneal thickness in the risk of early‑stage primary open‑angle glaucoma progression
title_full Synergic effect of corneal hysteresis and central corneal thickness in the risk of early‑stage primary open‑angle glaucoma progression
title_fullStr Synergic effect of corneal hysteresis and central corneal thickness in the risk of early‑stage primary open‑angle glaucoma progression
title_full_unstemmed Synergic effect of corneal hysteresis and central corneal thickness in the risk of early‑stage primary open‑angle glaucoma progression
title_sort Synergic effect of corneal hysteresis and central corneal thickness in the risk of early‑stage primary open‑angle glaucoma progression
dc.creator.none.fl_str_mv Jiménez Santos, María A.
Sáenz Francés, Federico
Sánchez Jean, Rubén
Martínez De La Casa Fernández-Borrella, José María
García Feijoo, Julián
Jañez Escalada, Luis
author Jiménez Santos, María A.
author_facet Jiménez Santos, María A.
Sáenz Francés, Federico
Sánchez Jean, Rubén
Martínez De La Casa Fernández-Borrella, José María
García Feijoo, Julián
Jañez Escalada, Luis
author_role author
author2 Sáenz Francés, Federico
Sánchez Jean, Rubén
Martínez De La Casa Fernández-Borrella, José María
García Feijoo, Julián
Jañez Escalada, Luis
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 617.7‑007.681
612.841
Perimetry
Primary open-angle glaucoma
Progression
Corneal hysteresis
Risk factors
Oftalmología
3201.09 Oftalmología
topic 617.7‑007.681
612.841
Perimetry
Primary open-angle glaucoma
Progression
Corneal hysteresis
Risk factors
Oftalmología
3201.09 Oftalmología
description Purpose: To evaluate corneal hysteresis (CH), acquired with ocular response analyzer (ORA), as a risk factor for glaucoma progression in early-stage primary open-angle glaucoma (POAG). Methods: In a historical cohort study, patients diagnosed in 2011 with early-stage POAG according to the Hodapp, Parrish and Anderson classification modified for Octopus perimetry and followed up until glaucomatous progression development; otherwise, observations were censored in October 2018. Cox regression was used to obtain hazard ratios (HR) to evaluate baseline variables (CH, central corneal thickness, gender, age IOP and glaucoma family history) as risk factors for perimetric glaucoma progression. A likelihood ratio test for interaction was performed in order to assess the effect of the combination of CH and CCT on the risk of progression. Results: Of the cohort of 1573 patients, 11.38% developed early-stage POAG progression during the follow-up. The mean follow-up time was 3.28 ± 1.92 years. Patients without progression had a higher CH (11.35 ± 1.43 vs 9.07 ± 1.69 mmHg; p < 0.001) and CCT (570.75 ± 17.71 vs 554.51 ± 23.20; p < 0.001). In the multivariate analysis, each 1 mmHg of lower CH was associated with an increase of 2.13 times in the HR of progression (95% CI: 1.92–2.32; p < 0.001). CH hazard ratio was modified by CCT, with higher values of CCT and CH resulting in a higher HR of early glaucoma progression (p < 0.001). Conclusions: CH can be considered as a risk factor of progression in early-stage POAG. The risk associated with CH changed depending on CCT values, acting synergistically slowing the risk of glaucoma progression with higher values.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-05-07
2021
2021-05-07
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/8156
url https://hdl.handle.net/20.500.14352/8156
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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