Effect of a diet supplemented with sphingomyelin and probiotics on colon cancer development in mice
Previous studies have reported that dietary sphingomyelin could inhibit early stages of colon cancer. Lactic acid–producing bacteria have also been associated with an amelioration of cancer symptoms. However, little is known about the potential beneficial effects of the combined administration of bo...
| Autores: | , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Universidad de Navarra |
| Repositorio: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | inglés |
| OAI Identifier: | oai:dadun.unav.edu:10171/119140 |
| Acceso en línea: | https://hdl.handle.net/10171/119140 |
| Access Level: | acceso abierto |
| Palabra clave: | Sphingomyelin Aberrant crypt foci Lacticaseibacillus casei Bifidobacterium bifidum 1.2-Dimethylhydrazine |
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Effect of a diet supplemented with sphingomyelin and probiotics on colon cancer development in miceMarzo, F. (Florencio)|||/items/e4e57922-efc1-4785-86fa-a212aa0e2db0Jauregui-Jiménez, P. (Patricia)|||/items/450c0aa3-9a2a-42ff-b4ad-5376ba01c0ebBarrenetxe, J. (Jaione)|||/items/26fd1663-5b96-4725-8d0c-c76ff51fba26Martínez-Peñuela, A. (Ana)|||/items/e09c4a93-6539-4360-b8c7-33f8f678b909Ibañez, F.C. (Francisco C.)|||/items/e660a791-f057-4de2-8b61-4ef5b3eb4235Milagro-Yoldi, F.I. (Fermín Ignacio)|||/items/07cf7af6-1f5f-4720-8c14-5197a7a724ebSphingomyelinAberrant crypt fociLacticaseibacillus caseiBifidobacterium bifidum1.2-DimethylhydrazinePrevious studies have reported that dietary sphingomyelin could inhibit early stages of colon cancer. Lactic acid–producing bacteria have also been associated with an amelioration of cancer symptoms. However, little is known about the potential beneficial effects of the combined administration of both sphingomyelin and lactic acid–producing bacteria. This article analyzes the effect of a diet supplemented with a combination of the probiotics Lacticaseibacillus casei and Bifidobacterium bifidum (108 CFU/ml) and sphingomyelin (0.05%) on mice with 1,2-dimethylhydrazine (DMH)-induced colon cancer. Thirtysix BALB/c mice were divided into 3 groups: one healthy group (group C) and two groups with DMH-induced cancer, one fed a standard diet (group D) and the other fed a diet supplemented with sphingomyelin and probiotics (DS). The number of aberrant crypt foci, marker of colon cancer development, was lower in the DS. The dietary supplementation with the synbiotic reversed the cancer-induced impairment of galactose uptake in enterocyte brush–border–membrane vesicles. These results confirm the beneficial effects of the synbiotic on the intestinal physiology of colon cancer mice and contribute to the understanding of the possible mechanisms involved.SpringerDadun. Depósito Académico Digital Universidad de Navarra20222022-01-0120222022-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/119140reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/1191402026-06-21T12:47:57Z |
| dc.title.none.fl_str_mv |
Effect of a diet supplemented with sphingomyelin and probiotics on colon cancer development in mice |
| title |
Effect of a diet supplemented with sphingomyelin and probiotics on colon cancer development in mice |
| spellingShingle |
Effect of a diet supplemented with sphingomyelin and probiotics on colon cancer development in mice Marzo, F. (Florencio)|||/items/e4e57922-efc1-4785-86fa-a212aa0e2db0 Sphingomyelin Aberrant crypt foci Lacticaseibacillus casei Bifidobacterium bifidum 1.2-Dimethylhydrazine |
| title_short |
Effect of a diet supplemented with sphingomyelin and probiotics on colon cancer development in mice |
| title_full |
Effect of a diet supplemented with sphingomyelin and probiotics on colon cancer development in mice |
| title_fullStr |
Effect of a diet supplemented with sphingomyelin and probiotics on colon cancer development in mice |
| title_full_unstemmed |
Effect of a diet supplemented with sphingomyelin and probiotics on colon cancer development in mice |
| title_sort |
Effect of a diet supplemented with sphingomyelin and probiotics on colon cancer development in mice |
| dc.creator.none.fl_str_mv |
Marzo, F. (Florencio)|||/items/e4e57922-efc1-4785-86fa-a212aa0e2db0 Jauregui-Jiménez, P. (Patricia)|||/items/450c0aa3-9a2a-42ff-b4ad-5376ba01c0eb Barrenetxe, J. (Jaione)|||/items/26fd1663-5b96-4725-8d0c-c76ff51fba26 Martínez-Peñuela, A. (Ana)|||/items/e09c4a93-6539-4360-b8c7-33f8f678b909 Ibañez, F.C. (Francisco C.)|||/items/e660a791-f057-4de2-8b61-4ef5b3eb4235 Milagro-Yoldi, F.I. (Fermín Ignacio)|||/items/07cf7af6-1f5f-4720-8c14-5197a7a724eb |
| author |
Marzo, F. (Florencio)|||/items/e4e57922-efc1-4785-86fa-a212aa0e2db0 |
| author_facet |
Marzo, F. (Florencio)|||/items/e4e57922-efc1-4785-86fa-a212aa0e2db0 Jauregui-Jiménez, P. (Patricia)|||/items/450c0aa3-9a2a-42ff-b4ad-5376ba01c0eb Barrenetxe, J. (Jaione)|||/items/26fd1663-5b96-4725-8d0c-c76ff51fba26 Martínez-Peñuela, A. (Ana)|||/items/e09c4a93-6539-4360-b8c7-33f8f678b909 Ibañez, F.C. (Francisco C.)|||/items/e660a791-f057-4de2-8b61-4ef5b3eb4235 Milagro-Yoldi, F.I. (Fermín Ignacio)|||/items/07cf7af6-1f5f-4720-8c14-5197a7a724eb |
| author_role |
author |
| author2 |
Jauregui-Jiménez, P. (Patricia)|||/items/450c0aa3-9a2a-42ff-b4ad-5376ba01c0eb Barrenetxe, J. (Jaione)|||/items/26fd1663-5b96-4725-8d0c-c76ff51fba26 Martínez-Peñuela, A. (Ana)|||/items/e09c4a93-6539-4360-b8c7-33f8f678b909 Ibañez, F.C. (Francisco C.)|||/items/e660a791-f057-4de2-8b61-4ef5b3eb4235 Milagro-Yoldi, F.I. (Fermín Ignacio)|||/items/07cf7af6-1f5f-4720-8c14-5197a7a724eb |
| author2_role |
author author author author author |
| dc.contributor.none.fl_str_mv |
Dadun. Depósito Académico Digital Universidad de Navarra |
| dc.subject.none.fl_str_mv |
Sphingomyelin Aberrant crypt foci Lacticaseibacillus casei Bifidobacterium bifidum 1.2-Dimethylhydrazine |
| topic |
Sphingomyelin Aberrant crypt foci Lacticaseibacillus casei Bifidobacterium bifidum 1.2-Dimethylhydrazine |
| description |
Previous studies have reported that dietary sphingomyelin could inhibit early stages of colon cancer. Lactic acid–producing bacteria have also been associated with an amelioration of cancer symptoms. However, little is known about the potential beneficial effects of the combined administration of both sphingomyelin and lactic acid–producing bacteria. This article analyzes the effect of a diet supplemented with a combination of the probiotics Lacticaseibacillus casei and Bifidobacterium bifidum (108 CFU/ml) and sphingomyelin (0.05%) on mice with 1,2-dimethylhydrazine (DMH)-induced colon cancer. Thirtysix BALB/c mice were divided into 3 groups: one healthy group (group C) and two groups with DMH-induced cancer, one fed a standard diet (group D) and the other fed a diet supplemented with sphingomyelin and probiotics (DS). The number of aberrant crypt foci, marker of colon cancer development, was lower in the DS. The dietary supplementation with the synbiotic reversed the cancer-induced impairment of galactose uptake in enterocyte brush–border–membrane vesicles. These results confirm the beneficial effects of the synbiotic on the intestinal physiology of colon cancer mice and contribute to the understanding of the possible mechanisms involved. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022 2022-01-01 2022 2022-01-01 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
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article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10171/119140 |
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https://hdl.handle.net/10171/119140 |
| dc.language.none.fl_str_mv |
Inglés eng |
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Inglés |
| language |
eng |
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open access http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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application/pdf |
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Springer |
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Springer |
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reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra |
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Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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