Uncovering Phytotoxic Compounds Produced by Colletotrichum spp. Involved in Legume Diseases Using an OSMAC–Metabolomics Approach

Different fungal species belonging to the Colletotrichum genus cause anthracnose disease in a range of major crops, resulting in huge economic losses worldwide. Typical symptoms include dark, sunken lesions on leaves, stems, or fruits. Colletotrichum spp. have synthesized, in vitro, a number of biol...

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Autores: Reveglia, Pierluigi, Agudo‐Jurado, Francisco J., Barilli, Eleonora, Masi, Marco, Evidente, Antonio, Rubiales, Diego
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/310555
Acceso en línea:http://hdl.handle.net/10261/310555
Access Level:acceso abierto
Palabra clave:Colletotrichum spp.
Fungal metabolites
Anthracnose
Legumes
Phytotoxins
Metabolomics
Chemotaxonomy
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spelling Uncovering Phytotoxic Compounds Produced by Colletotrichum spp. Involved in Legume Diseases Using an OSMAC–Metabolomics ApproachReveglia, PierluigiAgudo‐Jurado, Francisco J.Barilli, EleonoraMasi, MarcoEvidente, AntonioRubiales, DiegoColletotrichum spp.Fungal metabolitesAnthracnoseLegumesPhytotoxinsMetabolomicsChemotaxonomyDifferent fungal species belonging to the Colletotrichum genus cause anthracnose disease in a range of major crops, resulting in huge economic losses worldwide. Typical symptoms include dark, sunken lesions on leaves, stems, or fruits. Colletotrichum spp. have synthesized, in vitro, a number of biologically active and structurally unusual metabolites that are involved in their host’s infection process. In this study, we applied a one strain many compounds (OSMAC) approach, integrated with targeted and non-targeted metabolomics profiling, to shed light on the secondary phytotoxic metabolite panels produced by pathogenic isolates of Colletotrichum truncatum and Colletotrichum trifolii. The phytotoxicity of the fungal crude extracts was also assessed on their primary hosts and related legumes, and the results correlated with the metabolite profile that arose from the different cultural conditions. To the best of our knowledge, this is the first time that the OSMAC strategy integrated with metabolomics approaches has been applied to Colletotrichum species involved in legume diseases.This research was funded by the Spanish Agencia Estatal de Investigación (AEI), grant PID2020-114668RB-I00.Peer reviewedMultidisciplinary Digital Publishing InstituteMinisterio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2023202320232023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/310555reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-114668RB-I00Reveglia, Pierluigi; Agudo‐Jurado, Francisco J.; Barilli, Eleonora; Masi, Marco; Evidente, Antonio; Rubiales, Diego; 2023; Supplementary material. Uncovering Phytotoxic Compounds Produced by Colletotrichum spp. Involved in Legume Diseases Using an OSMAC–Metabolomics Approach [Dataset]; Multidisciplinary Digital Publishing Institute; https://www.mdpi.com/article/10.3390/jof9060610/s1https://doi.org/10.3390/jof9060610Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3105552026-05-22T06:33:51Z
dc.title.none.fl_str_mv Uncovering Phytotoxic Compounds Produced by Colletotrichum spp. Involved in Legume Diseases Using an OSMAC–Metabolomics Approach
title Uncovering Phytotoxic Compounds Produced by Colletotrichum spp. Involved in Legume Diseases Using an OSMAC–Metabolomics Approach
spellingShingle Uncovering Phytotoxic Compounds Produced by Colletotrichum spp. Involved in Legume Diseases Using an OSMAC–Metabolomics Approach
Reveglia, Pierluigi
Colletotrichum spp.
Fungal metabolites
Anthracnose
Legumes
Phytotoxins
Metabolomics
Chemotaxonomy
title_short Uncovering Phytotoxic Compounds Produced by Colletotrichum spp. Involved in Legume Diseases Using an OSMAC–Metabolomics Approach
title_full Uncovering Phytotoxic Compounds Produced by Colletotrichum spp. Involved in Legume Diseases Using an OSMAC–Metabolomics Approach
title_fullStr Uncovering Phytotoxic Compounds Produced by Colletotrichum spp. Involved in Legume Diseases Using an OSMAC–Metabolomics Approach
title_full_unstemmed Uncovering Phytotoxic Compounds Produced by Colletotrichum spp. Involved in Legume Diseases Using an OSMAC–Metabolomics Approach
title_sort Uncovering Phytotoxic Compounds Produced by Colletotrichum spp. Involved in Legume Diseases Using an OSMAC–Metabolomics Approach
dc.creator.none.fl_str_mv Reveglia, Pierluigi
Agudo‐Jurado, Francisco J.
Barilli, Eleonora
Masi, Marco
Evidente, Antonio
Rubiales, Diego
author Reveglia, Pierluigi
author_facet Reveglia, Pierluigi
Agudo‐Jurado, Francisco J.
Barilli, Eleonora
Masi, Marco
Evidente, Antonio
Rubiales, Diego
author_role author
author2 Agudo‐Jurado, Francisco J.
Barilli, Eleonora
Masi, Marco
Evidente, Antonio
Rubiales, Diego
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Colletotrichum spp.
Fungal metabolites
Anthracnose
Legumes
Phytotoxins
Metabolomics
Chemotaxonomy
topic Colletotrichum spp.
Fungal metabolites
Anthracnose
Legumes
Phytotoxins
Metabolomics
Chemotaxonomy
description Different fungal species belonging to the Colletotrichum genus cause anthracnose disease in a range of major crops, resulting in huge economic losses worldwide. Typical symptoms include dark, sunken lesions on leaves, stems, or fruits. Colletotrichum spp. have synthesized, in vitro, a number of biologically active and structurally unusual metabolites that are involved in their host’s infection process. In this study, we applied a one strain many compounds (OSMAC) approach, integrated with targeted and non-targeted metabolomics profiling, to shed light on the secondary phytotoxic metabolite panels produced by pathogenic isolates of Colletotrichum truncatum and Colletotrichum trifolii. The phytotoxicity of the fungal crude extracts was also assessed on their primary hosts and related legumes, and the results correlated with the metabolite profile that arose from the different cultural conditions. To the best of our knowledge, this is the first time that the OSMAC strategy integrated with metabolomics approaches has been applied to Colletotrichum species involved in legume diseases.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/310555
url http://hdl.handle.net/10261/310555
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-114668RB-I00
Reveglia, Pierluigi; Agudo‐Jurado, Francisco J.; Barilli, Eleonora; Masi, Marco; Evidente, Antonio; Rubiales, Diego; 2023; Supplementary material. Uncovering Phytotoxic Compounds Produced by Colletotrichum spp. Involved in Legume Diseases Using an OSMAC–Metabolomics Approach [Dataset]; Multidisciplinary Digital Publishing Institute; https://www.mdpi.com/article/10.3390/jof9060610/s1
https://doi.org/10.3390/jof9060610
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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