Correlates of non-target vessel-related adverse events in patients with ST-segment elevation myocardial infarction: insights from five-year follow-up of the EXAMINATION trial

Aims: The aim of this substudy was to determine the five-year correlates of non-TV-related adverse events (AE) in STEMI patients included in the EXAMINATION trial. Methods and results: The EXAMINATION trial randomised 1,498 STEMI patients to bare metal or everolimus-eluting stent implantation. In th...

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Autores: Spitaleri, G, Moscarella, E, Brugaletta, S, Pernigotti, A, Ortega-Paz, L, Gomez-Lara, J, Cequier, A, Iniguez, A, Serra, A, Jimenez-Quevedo, P, Mainar, V, Campo, G, Tespili, M, den Heijer, P, Bethencourt, A, Vazquez, N, Valgimigli, M, Serruys, PW, Sabate, M
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p3888
Acceso en línea:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3888
Access Level:acceso abierto
Palabra clave:bare metal stent
drug-eluting stent
multiple vessel disease
ST-elevation myocardial infarction (STEMI)
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spelling Correlates of non-target vessel-related adverse events in patients with ST-segment elevation myocardial infarction: insights from five-year follow-up of the EXAMINATION trialSpitaleri, GMoscarella, EBrugaletta, SPernigotti, AOrtega-Paz, LGomez-Lara, JCequier, AIniguez, ASerra, AJimenez-Quevedo, PMainar, VCampo, GTespili, Mden Heijer, PBethencourt, AVazquez, NValgimigli, MSerruys, PWSabate, Mbare metal stentdrug-eluting stentmultiple vessel diseaseST-elevation myocardial infarction (STEMI)Aims: The aim of this substudy was to determine the five-year correlates of non-TV-related adverse events (AE) in STEMI patients included in the EXAMINATION trial. Methods and results: The EXAMINATION trial randomised 1,498 STEMI patients to bare metal or everolimus-eluting stent implantation. In this substudy, patients were analysed according to non-TV-related AE, defined as the composite of either non-TV revascularisation (non-TVR) or non-TV-related myocardial infarction (MI). At five-year follow-up, 125 patients (8.3%) exhibited 136 non-TV-related AE (124 [8.3%] non-TVR, 12 [0.8%] non-TV-related MI), accounting for 47.1% of 289 non-fatal cardiac events overall. These patients had a higher incidence of diabetes mellitus (p<0.001), arterial hypertension (p=0.032), previous MI (p=0.073), multivessel disease (p<0.001), and incomplete revascularisation (p=0.049), and a lower rate of ST-segment resolution >70% (p=0.042) as compared to the rest. At Cox analysis, previous MI (HR 1.872, 95% CI: 1.004-3.489; p=0.048), incomplete revascularisation (HR 1.746, 95% CI: 1.029-2.963; p=0.039) and diabetes (HR 1.942, 95% CI: 1.292-2.919; p=0.001) were independent correlates of non-TV-related AE. Conclusions: In STEMI patients undergoing primary percutaneous coronary intervention, previous MI, incomplete revascularisation and diabetes resulted in being independent correlates of five-year non-TV-related AE.EUROPA EDITION2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3888EuroInterventionISSN: 1774024XISSNe: 19696213reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p38882026-06-14T12:41:47Z
dc.title.none.fl_str_mv Correlates of non-target vessel-related adverse events in patients with ST-segment elevation myocardial infarction: insights from five-year follow-up of the EXAMINATION trial
title Correlates of non-target vessel-related adverse events in patients with ST-segment elevation myocardial infarction: insights from five-year follow-up of the EXAMINATION trial
spellingShingle Correlates of non-target vessel-related adverse events in patients with ST-segment elevation myocardial infarction: insights from five-year follow-up of the EXAMINATION trial
Spitaleri, G
bare metal stent
drug-eluting stent
multiple vessel disease
ST-elevation myocardial infarction (STEMI)
title_short Correlates of non-target vessel-related adverse events in patients with ST-segment elevation myocardial infarction: insights from five-year follow-up of the EXAMINATION trial
title_full Correlates of non-target vessel-related adverse events in patients with ST-segment elevation myocardial infarction: insights from five-year follow-up of the EXAMINATION trial
title_fullStr Correlates of non-target vessel-related adverse events in patients with ST-segment elevation myocardial infarction: insights from five-year follow-up of the EXAMINATION trial
title_full_unstemmed Correlates of non-target vessel-related adverse events in patients with ST-segment elevation myocardial infarction: insights from five-year follow-up of the EXAMINATION trial
title_sort Correlates of non-target vessel-related adverse events in patients with ST-segment elevation myocardial infarction: insights from five-year follow-up of the EXAMINATION trial
dc.creator.none.fl_str_mv Spitaleri, G
Moscarella, E
Brugaletta, S
Pernigotti, A
Ortega-Paz, L
Gomez-Lara, J
Cequier, A
Iniguez, A
Serra, A
Jimenez-Quevedo, P
Mainar, V
Campo, G
Tespili, M
den Heijer, P
Bethencourt, A
Vazquez, N
Valgimigli, M
Serruys, PW
Sabate, M
author Spitaleri, G
author_facet Spitaleri, G
Moscarella, E
Brugaletta, S
Pernigotti, A
Ortega-Paz, L
Gomez-Lara, J
Cequier, A
Iniguez, A
Serra, A
Jimenez-Quevedo, P
Mainar, V
Campo, G
Tespili, M
den Heijer, P
Bethencourt, A
Vazquez, N
Valgimigli, M
Serruys, PW
Sabate, M
author_role author
author2 Moscarella, E
Brugaletta, S
Pernigotti, A
Ortega-Paz, L
Gomez-Lara, J
Cequier, A
Iniguez, A
Serra, A
Jimenez-Quevedo, P
Mainar, V
Campo, G
Tespili, M
den Heijer, P
Bethencourt, A
Vazquez, N
Valgimigli, M
Serruys, PW
Sabate, M
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv bare metal stent
drug-eluting stent
multiple vessel disease
ST-elevation myocardial infarction (STEMI)
topic bare metal stent
drug-eluting stent
multiple vessel disease
ST-elevation myocardial infarction (STEMI)
description Aims: The aim of this substudy was to determine the five-year correlates of non-TV-related adverse events (AE) in STEMI patients included in the EXAMINATION trial. Methods and results: The EXAMINATION trial randomised 1,498 STEMI patients to bare metal or everolimus-eluting stent implantation. In this substudy, patients were analysed according to non-TV-related AE, defined as the composite of either non-TV revascularisation (non-TVR) or non-TV-related myocardial infarction (MI). At five-year follow-up, 125 patients (8.3%) exhibited 136 non-TV-related AE (124 [8.3%] non-TVR, 12 [0.8%] non-TV-related MI), accounting for 47.1% of 289 non-fatal cardiac events overall. These patients had a higher incidence of diabetes mellitus (p<0.001), arterial hypertension (p=0.032), previous MI (p=0.073), multivessel disease (p<0.001), and incomplete revascularisation (p=0.049), and a lower rate of ST-segment resolution >70% (p=0.042) as compared to the rest. At Cox analysis, previous MI (HR 1.872, 95% CI: 1.004-3.489; p=0.048), incomplete revascularisation (HR 1.746, 95% CI: 1.029-2.963; p=0.039) and diabetes (HR 1.942, 95% CI: 1.292-2.919; p=0.001) were independent correlates of non-TV-related AE. Conclusions: In STEMI patients undergoing primary percutaneous coronary intervention, previous MI, incomplete revascularisation and diabetes resulted in being independent correlates of five-year non-TV-related AE.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3888
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3888
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv EUROPA EDITION
publisher.none.fl_str_mv EUROPA EDITION
dc.source.none.fl_str_mv EuroIntervention
ISSN: 1774024X
ISSNe: 19696213
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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