Gut microbiota in a rat oral sensitization model: effect of a cocoa-enriched diet

Increasing evidence is emerging suggesting a relation between dietary compounds, microbiota, and the susceptibility to allergic diseases, particularly food allergy. Cocoa, a source of antioxidant polyphenols, has shown effects on gut microbiota and the ability to promote tolerance in an oral sensiti...

ver descrição completa

Detalhes bibliográficos
Autores: Camps i Bossacoma, Mariona, Pérez-Cano, Francisco J., Franch i Masferrer, Àngels, Castell, Margarida
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2017
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositório:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/119498
Acesso em linha:https://hdl.handle.net/2445/119498
Access Level:Acceso aberto
Palavra-chave:Microbiota
Al·lèrgia alimentària
Cacau
Food allergy
Cocoa
id ES_e2fe95f89aacda24280a4e9909732785
oai_identifier_str oai:recercat.cat:2445/119498
network_acronym_str ES
network_name_str España
repository_id_str
spelling Gut microbiota in a rat oral sensitization model: effect of a cocoa-enriched dietCamps i Bossacoma, MarionaPérez-Cano, Francisco J.Franch i Masferrer, ÀngelsCastell, MargaridaMicrobiotaAl·lèrgia alimentàriaCacauMicrobiotaFood allergyCocoaIncreasing evidence is emerging suggesting a relation between dietary compounds, microbiota, and the susceptibility to allergic diseases, particularly food allergy. Cocoa, a source of antioxidant polyphenols, has shown effects on gut microbiota and the ability to promote tolerance in an oral sensitization model. Taking these facts into consideration, the aim of the present study was to establish the influence of an oral sensitization model, both alone and together with a cocoa-enriched diet, on gut microbiota. Lewis rats were orally sensitized and fed with either a standard or 10% cocoa diet. Faecal microbiota was analysed through metagenomics study. Intestinal IgA concentration was also determined. Oral sensitization produced few changes in intestinal microbiota, but in those rats fed a cocoa diet significant modifications appeared. Decreased bacteria from the Firmicutes and Proteobacteria phyla and a higher percentage of bacteria belonging to the Tenericutes and Cyanobacteria phyla were observed. In conclusion, a cocoa diet is able to modify the microbiota bacterial pattern in orally sensitized animals. As cocoa inhibits the synthesis of specific antibodies and also intestinal IgA, those changes in microbiota pattern, particularly those of the Proteobacteria phylum, might be partially responsible for the tolerogenic effect of cocoa.Hindawi2018201820172018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion12 p.application/pdfhttps://hdl.handle.net/2445/119498Articles publicats en revistes (Bioquímica i Fisiologia)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1155/2017/7417505Oxidative Medicine and Cellular Longevity, 2017, vol. 2017https://doi.org/10.1155/2017/7417505cc-by (c) Camps Bossacoma, Mariona et al., 2017http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1194982026-05-29T05:05:01Z
dc.title.none.fl_str_mv Gut microbiota in a rat oral sensitization model: effect of a cocoa-enriched diet
title Gut microbiota in a rat oral sensitization model: effect of a cocoa-enriched diet
spellingShingle Gut microbiota in a rat oral sensitization model: effect of a cocoa-enriched diet
Camps i Bossacoma, Mariona
Microbiota
Al·lèrgia alimentària
Cacau
Microbiota
Food allergy
Cocoa
title_short Gut microbiota in a rat oral sensitization model: effect of a cocoa-enriched diet
title_full Gut microbiota in a rat oral sensitization model: effect of a cocoa-enriched diet
title_fullStr Gut microbiota in a rat oral sensitization model: effect of a cocoa-enriched diet
title_full_unstemmed Gut microbiota in a rat oral sensitization model: effect of a cocoa-enriched diet
title_sort Gut microbiota in a rat oral sensitization model: effect of a cocoa-enriched diet
dc.creator.none.fl_str_mv Camps i Bossacoma, Mariona
Pérez-Cano, Francisco J.
Franch i Masferrer, Àngels
Castell, Margarida
author Camps i Bossacoma, Mariona
author_facet Camps i Bossacoma, Mariona
Pérez-Cano, Francisco J.
Franch i Masferrer, Àngels
Castell, Margarida
author_role author
author2 Pérez-Cano, Francisco J.
Franch i Masferrer, Àngels
Castell, Margarida
author2_role author
author
author
dc.subject.none.fl_str_mv Microbiota
Al·lèrgia alimentària
Cacau
Microbiota
Food allergy
Cocoa
topic Microbiota
Al·lèrgia alimentària
Cacau
Microbiota
Food allergy
Cocoa
description Increasing evidence is emerging suggesting a relation between dietary compounds, microbiota, and the susceptibility to allergic diseases, particularly food allergy. Cocoa, a source of antioxidant polyphenols, has shown effects on gut microbiota and the ability to promote tolerance in an oral sensitization model. Taking these facts into consideration, the aim of the present study was to establish the influence of an oral sensitization model, both alone and together with a cocoa-enriched diet, on gut microbiota. Lewis rats were orally sensitized and fed with either a standard or 10% cocoa diet. Faecal microbiota was analysed through metagenomics study. Intestinal IgA concentration was also determined. Oral sensitization produced few changes in intestinal microbiota, but in those rats fed a cocoa diet significant modifications appeared. Decreased bacteria from the Firmicutes and Proteobacteria phyla and a higher percentage of bacteria belonging to the Tenericutes and Cyanobacteria phyla were observed. In conclusion, a cocoa diet is able to modify the microbiota bacterial pattern in orally sensitized animals. As cocoa inhibits the synthesis of specific antibodies and also intestinal IgA, those changes in microbiota pattern, particularly those of the Proteobacteria phylum, might be partially responsible for the tolerogenic effect of cocoa.
publishDate 2017
dc.date.none.fl_str_mv 2017
2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/119498
url https://hdl.handle.net/2445/119498
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1155/2017/7417505
Oxidative Medicine and Cellular Longevity, 2017, vol. 2017
https://doi.org/10.1155/2017/7417505
dc.rights.none.fl_str_mv cc-by (c) Camps Bossacoma, Mariona et al., 2017
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Camps Bossacoma, Mariona et al., 2017
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 12 p.
application/pdf
dc.publisher.none.fl_str_mv Hindawi
publisher.none.fl_str_mv Hindawi
dc.source.none.fl_str_mv Articles publicats en revistes (Bioquímica i Fisiologia)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869422461164978176
score 15,812429

Registros relacionados