Enhancing the solubility of Indomethacin: a breakthrough with cocrystal formation
17 p.
| Autores: | , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Universidad de Alcalá (UAH) |
| Repositorio: | e_Buah Biblioteca Digital Universidad de Alcalá |
| Idioma: | inglés |
| OAI Identifier: | oai:ebuah.uah.es:10017/68320 |
| Acceso en línea: | http://hdl.handle.net/10017/68320 https://dx.doi.org/10.3390/ph18111610 |
| Access Level: | acceso abierto |
| Palabra clave: | Cocrystals Indomethacin Solubility Farmacia Biología y Biomedicina/Biología Pharmacy Biology |
| id |
ES_e2eb3270e62b05b0f6eee7ce7b0f9049 |
|---|---|
| oai_identifier_str |
oai:ebuah.uah.es:10017/68320 |
| network_acronym_str |
ES |
| network_name_str |
España |
| repository_id_str |
|
| spelling |
Enhancing the solubility of Indomethacin: a breakthrough with cocrystal formationPardo Laurel, HugoGuarnizo Herrero, Víctor|||0000-0001-9323-3388Martínez Alonso, BorjaPeña Fernández, María de los Ángeles|||0000-0002-0908-8286CocrystalsIndomethacinSolubilityFarmaciaBiología y Biomedicina/BiologíaPharmacyBiology17 p.Background/objectives: Pharmaceutical cocrystals have emerged as a promising strategy to enhance the solubility and bioavailability of poorly water-soluble drugs. Indomethacin (IND), classified as a Biopharmaceutics Classification System (BCS) Class II drug, exhibits low solubility but high permeability. This study aims to develop a synthesis method, evaluate cocrystal solubility/stability and the physicochemical properties of the pure components, and describe cocrystal solubility using a mathematical model. Methods: Cocrystals were synthesized via solvent evaporation, using ethanol, methanol, and ethyl acetate. The pure components, IND and benzoic acid (AcBz) were dissolved in each solvent and maintained in a thermostabilizer for 24 h. Cocrystal formation was confirmed by UV-V spectroscopy, differential scanning calorimetry (DSC), and infrared (IR) spectroscopy. Results: The results showed that the solubility of the cocrystals decreased with increasing benzoic acid concentration. Mathematical modelling revealed that solubility can be expressed as the product of the solubilities of the individual components and the stability constant of the solution complex. Among the solvents tested, ethanol exhibited the highest solubility and equilibrium constant (Keq) for IND-AcBz cocrystals, suggesting a greater molecular affinity and enhanced cocrystal formation. Conclusions: These findings demonstrate that the formation of the novel INDAcBz cocrystal significantly enhances Indomethacin solubility and thermodynamic stability. These results validate benzoic acid as an effective coformer and establish phase solubility diagrams (PSD) as predictive tools for rational cocrystal design, supporting the future development of optimized pharmaceutical formulations.20252025-10-24journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10017/68320https://dx.doi.org/10.3390/ph1811161041304855reponame:e_Buah Biblioteca Digital Universidad de Alcaláinstname:Universidad de Alcalá (UAH)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ebuah.uah.es:10017/683202026-06-18T11:13:07Z |
| dc.title.none.fl_str_mv |
Enhancing the solubility of Indomethacin: a breakthrough with cocrystal formation |
| title |
Enhancing the solubility of Indomethacin: a breakthrough with cocrystal formation |
| spellingShingle |
Enhancing the solubility of Indomethacin: a breakthrough with cocrystal formation Pardo Laurel, Hugo Cocrystals Indomethacin Solubility Farmacia Biología y Biomedicina/Biología Pharmacy Biology |
| title_short |
Enhancing the solubility of Indomethacin: a breakthrough with cocrystal formation |
| title_full |
Enhancing the solubility of Indomethacin: a breakthrough with cocrystal formation |
| title_fullStr |
Enhancing the solubility of Indomethacin: a breakthrough with cocrystal formation |
| title_full_unstemmed |
Enhancing the solubility of Indomethacin: a breakthrough with cocrystal formation |
| title_sort |
Enhancing the solubility of Indomethacin: a breakthrough with cocrystal formation |
| dc.creator.none.fl_str_mv |
Pardo Laurel, Hugo Guarnizo Herrero, Víctor|||0000-0001-9323-3388 Martínez Alonso, Borja Peña Fernández, María de los Ángeles|||0000-0002-0908-8286 |
| author |
Pardo Laurel, Hugo |
| author_facet |
Pardo Laurel, Hugo Guarnizo Herrero, Víctor|||0000-0001-9323-3388 Martínez Alonso, Borja Peña Fernández, María de los Ángeles|||0000-0002-0908-8286 |
| author_role |
author |
| author2 |
Guarnizo Herrero, Víctor|||0000-0001-9323-3388 Martínez Alonso, Borja Peña Fernández, María de los Ángeles|||0000-0002-0908-8286 |
| author2_role |
author author author |
| dc.subject.none.fl_str_mv |
Cocrystals Indomethacin Solubility Farmacia Biología y Biomedicina/Biología Pharmacy Biology |
| topic |
Cocrystals Indomethacin Solubility Farmacia Biología y Biomedicina/Biología Pharmacy Biology |
| description |
17 p. |
| publishDate |
2025 |
| dc.date.none.fl_str_mv |
2025 2025-10-24 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 NA http://purl.org/coar/version/c_be7fb7dd8ff6fe43 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10017/68320 https://dx.doi.org/10.3390/ph18111610 41304855 |
| url |
http://hdl.handle.net/10017/68320 https://dx.doi.org/10.3390/ph18111610 |
| identifier_str_mv |
41304855 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.source.none.fl_str_mv |
reponame:e_Buah Biblioteca Digital Universidad de Alcalá instname:Universidad de Alcalá (UAH) |
| instname_str |
Universidad de Alcalá (UAH) |
| reponame_str |
e_Buah Biblioteca Digital Universidad de Alcalá |
| collection |
e_Buah Biblioteca Digital Universidad de Alcalá |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1869422454121693184 |
| score |
15,811543 |