Mapping the self in the brain's default mode network

The brain's default mode network (DMN) has become closely associated with self-referential mental activity, particularly in the resting-state. While the DMN is important for such processes, it has functions other than self-reference, and self-referential processes are supported by regions o...

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Detalles Bibliográficos
Autores: Davey, Christopher G., Pujol, Jesús, Harrison, Ben J.
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2016
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/26230
Acceso en línea:http://hdl.handle.net/10230/26230
http://dx.doi.org/10.1016/j.neuroimage.2016.02.022
Access Level:acceso abierto
Palabra clave:Cervell -- Fisiologia
Cervell -- Localització de funcions
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spelling Mapping the self in the brain's default mode networkDavey, Christopher G.Pujol, JesúsHarrison, Ben J.Cervell -- FisiologiaCervell -- Localització de funcionsThe brain's default mode network (DMN) has become closely associated with self-referential mental activity, particularly in the resting-state. While the DMN is important for such processes, it has functions other than self-reference, and self-referential processes are supported by regions outside of the DMN. In our study of 88 participants, we examined self-referential and resting-state processes to clarify the extent to which DMN activity was common and distinct between the conditions. Within areas commonly activated by self-reference and rest we sought to identify those that showed additional functional specialization for self-referential processes: these being not only activated by self-reference and rest but also showing increased activity in self-reference versus rest. We examined the neural network properties of the identified 'core-self' DMN regions-in medial prefrontal cortex (MPFC), posterior cingulate cortex (PCC), and inferior parietal lobule-using dynamic causal modeling. The optimal model identified was one in which self-related processes were driven via PCC activity and moderated by the regulatory influences of MPFC. We thus confirm the significance of these regions for self-related processes and extend our understanding of their functionally specialized roles.This study was funded by a National Health and Medical Research Council of Australia (NHMRC) Project Grant (1064643; Principal Investigator, BJH). CGD was supported by an NHMRC Career Development Fellowship (1061757).Elsevier20162016info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/26230http://dx.doi.org/10.1016/j.neuroimage.2016.02.022reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésNeuroimage. 2016 May 15;132:390-7© 2016 Elsevier.licensed under the Creative Commmons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ http://dx.doi.org/10.1016/j.neuroimage.2016.02.022http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/262302026-06-12T07:21:37Z
dc.title.none.fl_str_mv Mapping the self in the brain's default mode network
title Mapping the self in the brain's default mode network
spellingShingle Mapping the self in the brain's default mode network
Davey, Christopher G.
Cervell -- Fisiologia
Cervell -- Localització de funcions
title_short Mapping the self in the brain's default mode network
title_full Mapping the self in the brain's default mode network
title_fullStr Mapping the self in the brain's default mode network
title_full_unstemmed Mapping the self in the brain's default mode network
title_sort Mapping the self in the brain's default mode network
dc.creator.none.fl_str_mv Davey, Christopher G.
Pujol, Jesús
Harrison, Ben J.
author Davey, Christopher G.
author_facet Davey, Christopher G.
Pujol, Jesús
Harrison, Ben J.
author_role author
author2 Pujol, Jesús
Harrison, Ben J.
author2_role author
author
dc.subject.none.fl_str_mv Cervell -- Fisiologia
Cervell -- Localització de funcions
topic Cervell -- Fisiologia
Cervell -- Localització de funcions
description The brain's default mode network (DMN) has become closely associated with self-referential mental activity, particularly in the resting-state. While the DMN is important for such processes, it has functions other than self-reference, and self-referential processes are supported by regions outside of the DMN. In our study of 88 participants, we examined self-referential and resting-state processes to clarify the extent to which DMN activity was common and distinct between the conditions. Within areas commonly activated by self-reference and rest we sought to identify those that showed additional functional specialization for self-referential processes: these being not only activated by self-reference and rest but also showing increased activity in self-reference versus rest. We examined the neural network properties of the identified 'core-self' DMN regions-in medial prefrontal cortex (MPFC), posterior cingulate cortex (PCC), and inferior parietal lobule-using dynamic causal modeling. The optimal model identified was one in which self-related processes were driven via PCC activity and moderated by the regulatory influences of MPFC. We thus confirm the significance of these regions for self-related processes and extend our understanding of their functionally specialized roles.
publishDate 2016
dc.date.none.fl_str_mv 2016
2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/26230
http://dx.doi.org/10.1016/j.neuroimage.2016.02.022
url http://hdl.handle.net/10230/26230
http://dx.doi.org/10.1016/j.neuroimage.2016.02.022
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Neuroimage. 2016 May 15;132:390-7
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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