R-Ras1 and R-Ras2 regulate mature oligodendrocyte subpopulations

In the mammalian central nervous system, axonal myelination, executed by mature oligodendrocytes (MOLs), enables rapid neural transmission. Conversely, myelin deficiencies are hallmark features of multiple sclerosis, optic neuromyelitis, and some leukodystrophies. Recent studies have highlighted tha...

ver descrição completa

Detalhes bibliográficos
Autores: Alcover-Sanchez, Berta, Garcia-Martin, Gonzalo, Paleo-García, Víctor, Quintas, Ana, Dopazo, Ana, Gruart, Agnès, Delgado-García, José María, de la Villa, Pedro, Wandosell, Francisco, Pereira, Marta P., Cubelos, Beatriz
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2025
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositório:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:dnet:digitalcsic_::2c997f8cd234dbb8232ca49c854912b3
Acesso em linha:http://hdl.handle.net/10261/426173
Access Level:Acceso aberto
Palavra-chave:mature oligodendrocytes
myelin
R-Ras
specification
subpopulation
id ES_e2e99f378fffca2d25f0dc8c480cb51b
oai_identifier_str oai:dnet:digitalcsic_::2c997f8cd234dbb8232ca49c854912b3
network_acronym_str ES
network_name_str España
repository_id_str
spelling R-Ras1 and R-Ras2 regulate mature oligodendrocyte subpopulationsAlcover-Sanchez, BertaGarcia-Martin, GonzaloPaleo-García, VíctorQuintas, AnaDopazo, AnaGruart, AgnèsDelgado-García, José Maríade la Villa, PedroWandosell, FranciscoPereira, Marta P.Cubelos, Beatrizmature oligodendrocytesmyelinR-RasspecificationsubpopulationIn the mammalian central nervous system, axonal myelination, executed by mature oligodendrocytes (MOLs), enables rapid neural transmission. Conversely, myelin deficiencies are hallmark features of multiple sclerosis, optic neuromyelitis, and some leukodystrophies. Recent studies have highlighted that MOLs are heterogeneous; however, how MOL subpopulations are specified and balanced in physiological settings is poorly understood. Previous works have demonstrated an essential role of the small GTPases R-Ras1 and R-Ras2 in the survival and myelination of oligodendrocytes. In this study, we aimed to determine how R-Ras1 and R-Ras2 contribute to the heterogeneity of MOL subpopulations. Our results evidence that R-Ras1 and R-Ras2 affect specification into the distinct subpopulations MOL1, MOL2, and MOL5/6, which in turn vary in their dependence of these GTPases. In R-Ras1 and/or R-Ras2 mutant mice, we observed an increase in the MOL1 subpopulation and a decrease in the MOL2 and MOL5/6 subpopulations. We identified R-Ras1 and R-Ras2 as key elements in balancing the heterogeneity of MOLs. Our results contribute to the understanding of the molecular mechanisms underlying the heterogeneity of MOLs and the myelination processes, which is crucial for innovating regenerative therapies for nervous system disorders.Ministerio de Ciencia, Innovación y Universidades. Spain, Grant/Award Numbers: PID2020-118189RB-I00, PID2021-1232690B-I00, PID2021-124801NB-I00John Wiley & SonsMinisterio de Ciencia, Innovación y Universidades (España)Ministerio de Ciencia e Innovación (España)Agencia Estatal de Investigación (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2026202620252026info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/426173reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-118189RB-I00info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-123269OB-I00info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-124801NB-I00http://dx.doi.org/10.1002/glia.24643Síinfo:eu-repo/semantics/openAccessoai:dnet:digitalcsic_::2c997f8cd234dbb8232ca49c854912b32026-05-22T06:33:51Z
dc.title.none.fl_str_mv R-Ras1 and R-Ras2 regulate mature oligodendrocyte subpopulations
title R-Ras1 and R-Ras2 regulate mature oligodendrocyte subpopulations
spellingShingle R-Ras1 and R-Ras2 regulate mature oligodendrocyte subpopulations
Alcover-Sanchez, Berta
mature oligodendrocytes
myelin
R-Ras
specification
subpopulation
title_short R-Ras1 and R-Ras2 regulate mature oligodendrocyte subpopulations
title_full R-Ras1 and R-Ras2 regulate mature oligodendrocyte subpopulations
title_fullStr R-Ras1 and R-Ras2 regulate mature oligodendrocyte subpopulations
title_full_unstemmed R-Ras1 and R-Ras2 regulate mature oligodendrocyte subpopulations
title_sort R-Ras1 and R-Ras2 regulate mature oligodendrocyte subpopulations
dc.creator.none.fl_str_mv Alcover-Sanchez, Berta
Garcia-Martin, Gonzalo
Paleo-García, Víctor
Quintas, Ana
Dopazo, Ana
Gruart, Agnès
Delgado-García, José María
de la Villa, Pedro
Wandosell, Francisco
Pereira, Marta P.
Cubelos, Beatriz
author Alcover-Sanchez, Berta
author_facet Alcover-Sanchez, Berta
Garcia-Martin, Gonzalo
Paleo-García, Víctor
Quintas, Ana
Dopazo, Ana
Gruart, Agnès
Delgado-García, José María
de la Villa, Pedro
Wandosell, Francisco
Pereira, Marta P.
Cubelos, Beatriz
author_role author
author2 Garcia-Martin, Gonzalo
Paleo-García, Víctor
Quintas, Ana
Dopazo, Ana
Gruart, Agnès
Delgado-García, José María
de la Villa, Pedro
Wandosell, Francisco
Pereira, Marta P.
Cubelos, Beatriz
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Ministerio de Ciencia e Innovación (España)
Agencia Estatal de Investigación (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv mature oligodendrocytes
myelin
R-Ras
specification
subpopulation
topic mature oligodendrocytes
myelin
R-Ras
specification
subpopulation
description In the mammalian central nervous system, axonal myelination, executed by mature oligodendrocytes (MOLs), enables rapid neural transmission. Conversely, myelin deficiencies are hallmark features of multiple sclerosis, optic neuromyelitis, and some leukodystrophies. Recent studies have highlighted that MOLs are heterogeneous; however, how MOL subpopulations are specified and balanced in physiological settings is poorly understood. Previous works have demonstrated an essential role of the small GTPases R-Ras1 and R-Ras2 in the survival and myelination of oligodendrocytes. In this study, we aimed to determine how R-Ras1 and R-Ras2 contribute to the heterogeneity of MOL subpopulations. Our results evidence that R-Ras1 and R-Ras2 affect specification into the distinct subpopulations MOL1, MOL2, and MOL5/6, which in turn vary in their dependence of these GTPases. In R-Ras1 and/or R-Ras2 mutant mice, we observed an increase in the MOL1 subpopulation and a decrease in the MOL2 and MOL5/6 subpopulations. We identified R-Ras1 and R-Ras2 as key elements in balancing the heterogeneity of MOLs. Our results contribute to the understanding of the molecular mechanisms underlying the heterogeneity of MOLs and the myelination processes, which is crucial for innovating regenerative therapies for nervous system disorders.
publishDate 2025
dc.date.none.fl_str_mv 2025
2026
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/426173
url http://hdl.handle.net/10261/426173
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-118189RB-I00
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-123269OB-I00
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-124801NB-I00
http://dx.doi.org/10.1002/glia.24643
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv John Wiley & Sons
publisher.none.fl_str_mv John Wiley & Sons
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869422453507227648
score 15,812429

Registros relacionados