Pathogenesis and New Pharmacological Approaches to Noise-Induced Hearing Loss: A Systematic Review

Noise-induced hearing loss (NIHL) is responsible for significant adverse effects on cognition, quality of life and work, social relationships, motor skills, and other psychological aspects. The severity of NIHL depends on individual patient characteristics, sound intensity, and mainly the duration o...

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Authors: Santaolalla Sánchez, Francisco Javier, Gutierrez Posso, Juan David, Santaolalla Montoya, Francisco, Zabala López de Maturana, Javier Aitor, Arrizabalaga Iriondo, Ane, Revuelta Aranberri, Miren, Sánchez del Rey, Ana Salomé
Format: article
Publication Date:2024
Country:España
Institution:Universidad del País Vasco
Repository:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/69622
Online Access:http://hdl.handle.net/10810/69622
Access Level:Open access
Keyword:inner ear
noise-induced hearing loss
noise exposure
acoustic trauma
reactive oxygen species
antioxidants
inflammation
anti-apoptotic drugs
anti-inflammatory treatment
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spelling Pathogenesis and New Pharmacological Approaches to Noise-Induced Hearing Loss: A Systematic ReviewSantaolalla Sánchez, Francisco JavierGutierrez Posso, Juan DavidSantaolalla Montoya, FranciscoZabala López de Maturana, Javier AitorArrizabalaga Iriondo, AneRevuelta Aranberri, MirenSánchez del Rey, Ana Saloméinner earnoise-induced hearing lossnoise exposureacoustic traumareactive oxygen speciesantioxidantsinflammationanti-apoptotic drugsanti-inflammatory treatmentNoise-induced hearing loss (NIHL) is responsible for significant adverse effects on cognition, quality of life and work, social relationships, motor skills, and other psychological aspects. The severity of NIHL depends on individual patient characteristics, sound intensity, and mainly the duration of sound exposure. NIHL leads to the production of a reactive oxygen (ROS) inflammatory response and the activation of apoptotic pathways, DNA fragmentation, and cell death. In this situation, antioxidants can interact with free radicals as well as anti-apoptotics or anti-inflammatory substances and stop the reaction before vital molecules are damaged. Therefore, the aim of this study was to analyze the effects of different pharmacological treatments, focusing on exogenous antioxidants, anti-inflammatories, and anti-apoptotics to reduce the cellular damage caused by acoustic trauma in the inner ear. Experimental animal studies using these molecules have shown that they protect hair cells and reduce hearing loss due to acoustic trauma. However, there is a need for more conclusive evidence demonstrating the protective effects of antioxidant/anti-inflammatory or anti-apoptotic drugs’ administration, the timeline in which they exert their pharmacological action, and the dose in which they should be used in order to consider them as therapeutic drugs. Further studies are needed to fully understand the potential of these drugs as they may be a promising option to prevent and treat noise-induced hearing loss.The author(s) declare financial support was received for the research, authorship, and/or publication of this article. The work was financed by IIS Biobizkaia and the University of the Basque Country UPV/EHU (GIU22-015).MDPI2024202420242024info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/69622reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoIngléshttps://www.mdpi.com/2076-3921/13/9/1105info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/es/© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/).oai:addi.ehu.eus:10810/696222026-06-18T09:23:17Z
dc.title.none.fl_str_mv Pathogenesis and New Pharmacological Approaches to Noise-Induced Hearing Loss: A Systematic Review
title Pathogenesis and New Pharmacological Approaches to Noise-Induced Hearing Loss: A Systematic Review
spellingShingle Pathogenesis and New Pharmacological Approaches to Noise-Induced Hearing Loss: A Systematic Review
Santaolalla Sánchez, Francisco Javier
inner ear
noise-induced hearing loss
noise exposure
acoustic trauma
reactive oxygen species
antioxidants
inflammation
anti-apoptotic drugs
anti-inflammatory treatment
title_short Pathogenesis and New Pharmacological Approaches to Noise-Induced Hearing Loss: A Systematic Review
title_full Pathogenesis and New Pharmacological Approaches to Noise-Induced Hearing Loss: A Systematic Review
title_fullStr Pathogenesis and New Pharmacological Approaches to Noise-Induced Hearing Loss: A Systematic Review
title_full_unstemmed Pathogenesis and New Pharmacological Approaches to Noise-Induced Hearing Loss: A Systematic Review
title_sort Pathogenesis and New Pharmacological Approaches to Noise-Induced Hearing Loss: A Systematic Review
dc.creator.none.fl_str_mv Santaolalla Sánchez, Francisco Javier
Gutierrez Posso, Juan David
Santaolalla Montoya, Francisco
Zabala López de Maturana, Javier Aitor
Arrizabalaga Iriondo, Ane
Revuelta Aranberri, Miren
Sánchez del Rey, Ana Salomé
author Santaolalla Sánchez, Francisco Javier
author_facet Santaolalla Sánchez, Francisco Javier
Gutierrez Posso, Juan David
Santaolalla Montoya, Francisco
Zabala López de Maturana, Javier Aitor
Arrizabalaga Iriondo, Ane
Revuelta Aranberri, Miren
Sánchez del Rey, Ana Salomé
author_role author
author2 Gutierrez Posso, Juan David
Santaolalla Montoya, Francisco
Zabala López de Maturana, Javier Aitor
Arrizabalaga Iriondo, Ane
Revuelta Aranberri, Miren
Sánchez del Rey, Ana Salomé
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv inner ear
noise-induced hearing loss
noise exposure
acoustic trauma
reactive oxygen species
antioxidants
inflammation
anti-apoptotic drugs
anti-inflammatory treatment
topic inner ear
noise-induced hearing loss
noise exposure
acoustic trauma
reactive oxygen species
antioxidants
inflammation
anti-apoptotic drugs
anti-inflammatory treatment
description Noise-induced hearing loss (NIHL) is responsible for significant adverse effects on cognition, quality of life and work, social relationships, motor skills, and other psychological aspects. The severity of NIHL depends on individual patient characteristics, sound intensity, and mainly the duration of sound exposure. NIHL leads to the production of a reactive oxygen (ROS) inflammatory response and the activation of apoptotic pathways, DNA fragmentation, and cell death. In this situation, antioxidants can interact with free radicals as well as anti-apoptotics or anti-inflammatory substances and stop the reaction before vital molecules are damaged. Therefore, the aim of this study was to analyze the effects of different pharmacological treatments, focusing on exogenous antioxidants, anti-inflammatories, and anti-apoptotics to reduce the cellular damage caused by acoustic trauma in the inner ear. Experimental animal studies using these molecules have shown that they protect hair cells and reduce hearing loss due to acoustic trauma. However, there is a need for more conclusive evidence demonstrating the protective effects of antioxidant/anti-inflammatory or anti-apoptotic drugs’ administration, the timeline in which they exert their pharmacological action, and the dose in which they should be used in order to consider them as therapeutic drugs. Further studies are needed to fully understand the potential of these drugs as they may be a promising option to prevent and treat noise-induced hearing loss.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/69622
url http://hdl.handle.net/10810/69622
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://www.mdpi.com/2076-3921/13/9/1105
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/es/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/es/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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